{"id":15927,"date":"2021-02-20T21:09:00","date_gmt":"2021-02-21T02:09:00","guid":{"rendered":"https:\/\/nebula.org\/blog\/%d9%83%d9%84%d9%8a%d9%86%d9%81%d8%a7%d8%b1-%d8%aa%d8%b9%d9%84%d9%8a%d9%85%d9%8a\/"},"modified":"2021-02-20T21:09:03","modified_gmt":"2021-02-21T02:09:03","slug":"%d9%83%d9%84%d9%8a%d9%86%d9%81%d8%a7%d8%b1-%d8%aa%d8%b9%d9%84%d9%8a%d9%85%d9%8a","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/ar\/%d9%83%d9%84%d9%8a%d9%86%d9%81%d8%a7%d8%b1-%d8%aa%d8%b9%d9%84%d9%8a%d9%85%d9%8a\/","title":{"rendered":"\u0643\u064a\u0641\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 ClinVar &#8211; \u0628\u0631\u0646\u0627\u0645\u062c \u062a\u0639\u0644\u064a\u0645\u064a \u0644\u0644\u0645\u0628\u062a\u062f\u0626\u064a\u0646"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>\u0645\u0627 \u0647\u0648 ClinVar\u061f<\/strong><\/h2>\n\n<p>\u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0646\u0627\u0633 \u060c \u0641\u0625\u0646 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u062e\u0627\u0635 \u0628\u0647\u0645 \u0647\u0648 \u0628\u062f\u0627\u064a\u0629 \u0631\u062d\u0644\u0629 \u0645\u062b\u064a\u0631\u0629. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0630\u0644\u0643 \u060c \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u064f\u062a\u0631\u0643 \u0627\u0644\u0646\u0627\u0633 \u063a\u064a\u0631 \u0645\u062a\u0623\u0643\u062f\u064a\u0646 \u0645\u0646 \u0623\u064a\u0646 \u064a\u0628\u062f\u0623\u0648\u0646 \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0645. \u0644\u0645\u0639\u0631\u0641\u0629 \u0643\u064a\u0641 \u062a\u0624\u062b\u0631 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0635\u062d\u0629 \u060c \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0623\u062f\u0627\u0629 \u062a\u0633\u0645\u0649 ClinVar \u0645\u0641\u064a\u062f\u0629 \u0644\u0644\u063a\u0627\u064a\u0629. \u0648\u0644\u0643\u0646 \u060c \u0643\u064a\u0641 \u062a\u0639\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0627\u0629 \u0628\u0627\u0644\u0636\u0628\u0637\u061f \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0646\u0627\u0645\u062c \u0627\u0644\u062a\u0639\u0644\u064a\u0645\u064a \u0633\u0648\u0641 \u064a\u0639\u0644\u0645\u0643!<\/p>\n\n<figure class=\"wp-block-table is-style-regular\"><table class=\"has-subtle-pale-pink-background-color has-background\"><tbody><tr><td><strong><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">\u0647\u0644 \u0623\u0646\u062a \u0645\u0647\u062a\u0645 \u0628\u0627\u0643\u062a\u0634\u0627\u0641 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062e\u0627\u0635 \u0628\u0643 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u062f\u0648\u0627\u062a \u0645\u062b\u0644 ClinVar\u061f \u062a\u0642\u062f\u0645 Nebula Genomics \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0643\u0627\u0645\u0644 \u0645\u0642\u0627\u0628\u0644 299 \u062f\u0648\u0644\u0627\u0631\u064b\u0627 \u0641\u0642\u0637! \u0627\u0646\u0642\u0631 \u0647\u0646\u0627 \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f!<\/a><\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n<h2 class=\"wp-block-heading\">\u0627\u0644 99.9 \u0641\u064a \u0627\u0644\u0645\u0626\u0629<\/h2>\n\n<p>\u064a\u062a\u0643\u0648\u0646 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0628\u0634\u0631\u064a \u0645\u0646 \u062d\u0648\u0627\u0644\u064a 3 \u0645\u0644\u064a\u0627\u0631\u0627\u062a \u062d\u0631\u0641 \u0645\u0648\u0632\u0639\u0629 \u0639\u0644\u0649 23 \u0632\u0648\u062c\u064b\u0627 \u0645\u0646 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645\u0627\u062a. \u062a\u0639\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u0623\u062d\u0631\u0641 \u0645\u0639\u064b\u0627 (\u0627\u0644\u0645\u0639\u0631\u0648\u0641\u0629 \u0623\u064a\u0636\u064b\u0627 \u0628\u0627\u0633\u0645 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a) \u0643\u062f\u0644\u064a\u0644 \u0625\u0631\u0634\u0627\u062f\u064a \u0644\u062a\u062d\u062f\u064a\u062f \u0633\u0645\u0627\u062a\u0646\u0627. \u0645\u0646 \u0644\u0648\u0646 \u0634\u0639\u0631 \u0627\u0644\u0641\u0631\u062f \u0625\u0644\u0649 \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u060c \u064a\u062d\u062a\u0648\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0639\u0644\u0649 \u0627\u0644\u0648\u0635\u0641\u0629 \u0627\u0644\u062a\u064a \u062a\u062c\u0639\u0644 \u0643\u0644 \u0634\u062e\u0635 \u0641\u0631\u064a\u062f\u064b\u0627. <\/p>\n\n<p>\u0627\u062e\u062a\u0631 \u0634\u062e\u0635\u064a\u0646 \u0628\u0634\u0643\u0644 \u0639\u0634\u0648\u0627\u0626\u064a \u060c \u0648\u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0644\u062f\u064a\u0647\u0645 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0623\u0643\u062b\u0631 \u0645\u0646 \u0623\u0648\u062c\u0647 \u0627\u0644\u062a\u0634\u0627\u0628\u0647. \u0642\u062f \u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0631\u0621 \u0637\u0648\u064a\u0644\u0627\u064b \u060c \u0648\u064a\u062d\u062a\u0627\u062c \u0625\u0644\u0649 \u0646\u0638\u0627\u0631\u0627\u062a \u060c \u0648\u0644\u0647 \u062a\u0627\u0631\u064a\u062e \u0639\u0627\u0626\u0644\u064a \u0645\u0646 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0648\u064a\u0643\u0631\u0647 \u0637\u0639\u0645 \u0627\u0644\u0643\u0632\u0628\u0631\u0629. \u0627\u0644\u0622\u062e\u0631 \u0644\u062f\u064a\u0647 \u0634\u0639\u0631 \u0623\u062d\u0645\u0631 \u060c \u0648\u0647\u0648 \u0644\u0627 \u064a\u062a\u062d\u0645\u0644 \u0627\u0644\u0644\u0627\u0643\u062a\u0648\u0632 \u060c \u0648\u0643\u0627\u0646 \u062f\u0627\u0626\u0645\u064b\u0627 \u0637\u0627\u0644\u0628\u064b\u0627 \u0645\u0633\u062a\u0642\u064a\u0645\u064b\u0627. <\/p>\n\n<p>\u0641\u064a \u062d\u064a\u0646 \u0623\u0646 \u0647\u0630\u064a\u0646 \u0627\u0644\u0634\u062e\u0635\u064a\u0646 \u0642\u062f \u0644\u0627 \u064a\u0628\u062f\u0648\u0627\u0646 \u0645\u062a\u0634\u0627\u0628\u0647\u064a\u0646 \u060c \u0625\u0644\u0627 \u0623\u0646\u0647\u0645\u0627 \u0644\u0627 \u064a\u0632\u0627\u0644\u0627\u0646 \u064a\u062a\u0634\u0627\u0631\u0643\u0627\u0646 99.9\u066a \u0645\u0646 \u0646\u0641\u0633 \u0627\u0644\u0623\u062d\u0631\u0641 \u0641\u064a \u062c\u064a\u0646\u0648\u0645\u0647\u0645\u0627. \u0643\u0644 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641 \u0628\u064a\u0646 \u0641\u0631\u062f\u064a\u0646 \u0639\u0634\u0648\u0627\u0626\u064a\u064a\u0646 \u060c \u0645\u0646 \u0645\u0638\u0647\u0631\u0647\u0645\u0627 \u0625\u0644\u0649 \u0645\u062e\u0627\u0637\u0631 \u0627\u0644\u0645\u0631\u0636 \u060c \u064a\u0646\u0628\u0639 \u0645\u0646 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0641\u064a 0.1\u066a \u0641\u0642\u0637 (\u0623\u0648 3 \u0645\u0644\u0627\u064a\u064a\u0646) \u0645\u0646 \u0627\u0644\u062d\u0631\u0648\u0641 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645!<\/p>\n\n<h2 class=\"wp-block-heading\">0.1 \u0641\u064a \u0627\u0644\u0645\u0626\u0629<\/h2>\n\n<p>\u062a\u064f\u0639\u0631\u0641 \u0623\u062d\u0631\u0641 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u062a\u064a \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0643\u0648\u0646 \u0645\u062e\u062a\u0644\u0641\u0629 \u0628\u064a\u0646 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0628\u0627\u0633\u0645 \u062a\u0639\u062f\u062f \u0623\u0634\u0643\u0627\u0644 \u0627\u0644\u0646\u0648\u0643\u0644\u064a\u0648\u062a\u064a\u062f\u0627\u062a \u0627\u0644\u0645\u0641\u0631\u062f\u0629 \u060c \u0623\u0648 SNPs (\u062a\u064f\u0646\u0637\u0642 &#8220;\u0642\u0635\u0627\u0635\u0627\u062a&#8221;). \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u060c \u064a\u0648\u062c\u062f SNP \u0625\u0630\u0627 \u0643\u0627\u0646 \u0644\u062f\u0649 \u063a\u0627\u0644\u0628\u064a\u0629 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u062d\u0631\u0641 &#8220;C&#8221; \u0641\u064a \u0645\u0643\u0627\u0646 \u0645\u0639\u064a\u0646 \u0641\u064a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0628\u064a\u0646\u0645\u0627 \u0644\u062f\u0649 \u0627\u0644\u0623\u0642\u0644\u064a\u0629 \u0627\u0644\u062d\u0631\u0641 &#8220;T&#8221; \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0630\u0644\u0643. \u064a\u064f\u0642\u0627\u0644 \u0623\u0646 \u0647\u0630\u0627 SNP \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0645\u062a\u063a\u064a\u0631\u064a\u0646 \u0645\u062d\u062a\u0645\u0644\u064a\u0646 \u060c \u0623\u0648 &#8220;\u0623\u0644\u064a\u0644\u0627\u062a&#8221;: C \u0648 T.<\/p>\n\n<p>\u064a\u0642\u062f\u0631 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0623\u0646\u0647 \u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u0645\u0627 \u064a\u0635\u0644 \u0625\u0644\u0649 100 \u0645\u0644\u064a\u0648\u0646 SNPs \u0639\u0628\u0631 \u0627\u0644\u062c\u064a\u0646\u0648\u0645. \u062a\u062d\u062f\u062b \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u0648\u062a\u0627\u064a\u062f \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u064a\u0646\u0627\u062a \u060c \u062a\u0633\u0644\u0633\u0644\u0627\u062a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062a\u064a \u062a\u0639\u0645\u0644 \u0643\u062a\u0639\u0644\u064a\u0645\u0627\u062a \u0644\u0635\u0646\u0639 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u060c \u0648\u0627\u0644\u0622\u0644\u0627\u062a \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0624\u062f\u064a \u0645\u0647\u0627\u0645\u064b\u0627 \u0645\u062e\u062a\u0644\u0641\u0629 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u062e\u0627\u0631\u062c\u0647\u0627. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0630\u0644\u0643 \u060c \u062a\u062d\u062f\u062b \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u0648\u062a\u0627\u064a\u062f \u062e\u0627\u0631\u062c \u0647\u0630\u0647 \u0627\u0644\u0645\u0646\u0627\u0637\u0642 \u060c \u0641\u064a \u0645\u0627 \u064a\u0633\u0645\u0649<a href=\"https:\/\/www.scientificamerican.com\/article\/what-is-junk-dna-and-what\/\"> &#8220;\u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u063a\u064a\u0631 \u0627\u0644\u0645\u0631\u063a\u0648\u0628 \u0641\u064a\u0647&#8221;<\/a> . \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0627\u0633\u0645\u0647 \u060c \u064a\u0634\u062a\u0645\u0644 \u0647\u0630\u0627 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0639\u0644\u0649 \u062d\u0648\u0627\u0644\u064a 99\u066a \u0645\u0646 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0644\u062f\u064a\u0646\u0627 \u060c \u0648\u064a\u0633\u062a\u0645\u0631 \u0627\u0644\u0639\u0644\u0645\u0627\u0621 \u0641\u064a \u0627\u0643\u062a\u0634\u0627\u0641 \u0627\u0644\u0645\u0632\u064a\u062f \u0648\u0627\u0644\u0645\u0632\u064a\u062f \u062d\u0648\u0644 \u0623\u0647\u0645\u064a\u062a\u0647 \u0644\u0635\u062d\u062a\u0646\u0627.<\/p>\n\n<p>\u0628\u063a\u0636 \u0627\u0644\u0646\u0638\u0631 \u060c \u0641\u0625\u0646 \u062a\u062d\u062f\u064a\u062f \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0647\u0648 \u062e\u0637\u0648\u0629 \u0623\u0633\u0627\u0633\u064a\u0629 \u0641\u064a \u0641\u0647\u0645 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a\u0629 \u0627\u0644\u0634\u062e\u0635\u064a\u0629. \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0644\u0628\u0639\u0636 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u0648\u062a\u0627\u064a\u062f \u062a\u0623\u062b\u064a\u0631 \u0642\u0648\u064a \u0639\u0644\u0649 \u0642\u0627\u0628\u0644\u064a\u0629 \u0627\u0644\u0641\u0631\u062f \u0644\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0645\u0631\u0636 \u0645\u0639\u064a\u0646. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u060c \u0636\u0639 \u0641\u064a \u0627\u0639\u062a\u0628\u0627\u0631\u0643 \u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631. \u0647\u0646\u0627\u0643 SNP \u062e\u0627\u0635 \u0641\u064a \u0645\u0644\u0641<a href=\"https:\/\/nebula.org\/blog\/ar\/%d8%a3%d8%a8%d9%88%d9%84%d9%8a%d8%a8%d9%88%d8%a8%d8%b1%d9%88%d8%aa%d9%8a%d9%86-%d8%a3%d8%a8%d9%88%d9%8a\/\"> APOE<\/a> \u0627\u0644\u062c\u064a\u0646 \u064a\u0632\u064a\u062f \u0645\u0646 \u062e\u0637\u0631 \u0625\u0635\u0627\u0628\u0629 \u0627\u0644\u0634\u062e\u0635 \u0628\u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631<a href=\"https:\/\/nebula.org\/blog\/ar\/%d8%a3%d8%a8%d9%88%d9%84%d9%8a%d8%a8%d9%88%d8%a8%d8%b1%d9%88%d8%aa%d9%8a%d9%86-%d8%a3%d8%a8%d9%88%d9%8a\/\"> \u0623\u0643\u062b\u0631 \u0645\u0646 20 \u0636\u0639\u0641\u064b\u0627<\/a> ! <\/p>\n\n<p>\u0645\u0639 \u0627\u0644\u062a\u0642\u062f\u0645 \u0641\u064a \u062a\u0642\u0646\u064a\u0627\u062a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0642\u0644\u0644 \u0645\u0646 \u062a\u0643\u0644\u0641\u0629 \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0628\u0634\u0631\u064a \u060c \u064a\u0642\u0648\u0645 \u0627\u0644\u0645\u0632\u064a\u062f \u0648\u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0646\u0627\u0633 \u0628\u0647\u0630\u0647 \u0627\u0644\u0642\u0641\u0632\u0629 \u0644\u0644\u062a\u0639\u0631\u0641 \u0639\u0644\u0649 \u0623\u0646\u0641\u0633\u0647\u0645 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062e\u0627\u0635 \u0628\u0647\u0645. \u062a\u0645\u0646\u062d \u0628\u0639\u0636 \u0634\u0631\u0643\u0627\u062a \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0645\u0633\u062a\u062e\u062f\u0645\u064a\u0647\u0627 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u0649 \u0645\u0644\u0641\u0627\u062a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062e\u0627\u0645 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0645 \u060c \u0644\u062a\u0645\u0643\u064a\u0646\u0647\u0645 \u0645\u0646 \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0628\u064a\u0627\u0646\u0627\u062a\u0647\u0645 \u0628\u0623\u0646\u0641\u0633\u0647\u0645. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 \u0647\u0630\u0627 \u064a\u0645\u0643\u0651\u0646 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u064a\u0646 \u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u0642\u062f \u064a\u0643\u0648\u0646 \u0634\u0627\u0642\u064b\u0627 \u0644\u0644\u063a\u0627\u064a\u0629 \u0641\u064a \u0646\u0641\u0633 \u0627\u0644\u0648\u0642\u062a. \u0645\u0639\u0638\u0645 \u0627\u0644\u0646\u0627\u0633 \u0644\u064a\u0633\u0648\u0627 \u0639\u0644\u0649 \u062f\u0631\u0627\u064a\u0629 \u0628\u0639\u0644\u0645 \u0627\u0644\u0648\u0631\u0627\u062b\u0629 \u0627\u0644\u0628\u0634\u0631\u064a\u0629 \u0648\u0623\u062f\u0648\u0627\u062a \u062a\u062d\u0644\u064a\u0644 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0644\u0641\u0629. \u0639\u0644\u0649 \u0648\u062c\u0647 \u0627\u0644\u062e\u0635\u0648\u0635 \u060c \u0646\u0638\u0631\u064b\u0627 \u0644\u0645\u0644\u0627\u064a\u064a\u0646 \u0627\u0644\u0646\u064a\u0648\u0643\u0644\u0648\u062a\u0627\u064a\u062f SNPs \u060c \u0645\u0646 \u0627\u0644\u0645\u0641\u0647\u0648\u0645 \u0623\u0646 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0633\u062a\u062e\u062f\u0645\u064a\u0646 \u0644\u0627 \u064a\u0639\u0631\u0641\u0648\u0646 \u0643\u064a\u0641\u064a\u0629 \u0645\u0639\u0631\u0641\u0629 \u0645\u0627 \u064a\u0642\u0635\u062f\u0648\u0646\u0647. <\/p>\n\n<p>\u0647\u0644 \u0623\u0646\u062a \u0645\u0647\u062a\u0645 \u0628\u0627\u0643\u062a\u0634\u0627\u0641 \u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062e\u0627\u0635 \u0628\u0643 \u0644\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u0645\u0639\u0638\u0645 \u0627\u0644\u0623\u062f\u0648\u0627\u062a \u0645\u062b\u0644 ClinVar\u061f \u062a\u0642\u062f\u0645 Nebula Genomics \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u0643\u0627\u0645\u0644 \u0645\u0642\u0627\u0628\u0644 299 \u062f\u0648\u0644\u0627\u0631\u064b\u0627 \u0641\u0642\u0637! \u0627\u0646\u0642\u0631 \u0647\u0646\u0627 \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f!<\/p>\n\n<h2 class=\"wp-block-heading\">\u0643\u064a\u0641 \u062a\u0633\u062a\u0639\u0645\u0644<strong> \u0643\u0644\u064a\u0646\u0641\u0627\u0631<\/strong><\/h2>\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/\">\u064a\u0639\u062f ClinVar \u0623\u062d\u062f \u0623\u0643\u062b\u0631 \u0627\u0644\u0623\u062f\u0648\u0627\u062a \u0627\u0644\u0645\u0641\u064a\u062f\u0629 \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u062d\u0648\u0644 \u0645\u0627 \u0642\u062f \u062a\u0639\u0646\u064a\u0647 SNPs \u0644\u0644\u0635\u062d\u0629.<\/a> \u0625\u0646\u0647 \u0623\u0631\u0634\u064a\u0641 \u0639\u0627\u0645 \u064a\u0645\u0643\u0646 \u0627\u0644\u0648\u0635\u0648\u0644 \u0625\u0644\u064a\u0647 \u0645\u062c\u0627\u0646\u064b\u0627 \u0648\u064a\u0647\u062f\u0641 \u0625\u0644\u0649 \u0641\u0647\u0631\u0633\u0629 \u0627\u0644\u0639\u0644\u0627\u0642\u0627\u062a \u0628\u064a\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u062a\u0623\u062b\u064a\u0631\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0635\u062d\u064a\u0629. <\/p>\n\n<p>\u064a\u062a\u0645 \u062a\u0634\u063a\u064a\u0644 ClinVar \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u0645\u0639\u0627\u0647\u062f \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0644\u0644\u0635\u062d\u0629 \u0641\u064a \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629. \u064a\u0639\u0645\u0644 \u0643\u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0631\u0643\u0632\u064a\u0629 \u0639\u0627\u0645\u0629 \u0644\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0648\u0627\u0644\u0645\u0647\u0646\u064a\u064a\u0646 \u0627\u0644\u0637\u0628\u064a\u064a\u0646 \u0644\u0625\u064a\u062f\u0627\u0639 \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062d\u0648\u0644 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0630\u0627\u062a \u0627\u0644\u0635\u0644\u0629 \u0633\u0631\u064a\u0631\u064a\u064b\u0627. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u060c \u0625\u0630\u0627 \u062a\u0645 \u0646\u0634\u0631 \u062f\u0631\u0627\u0633\u0629 \u0639\u0644\u0645\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u062a\u0631\u0628\u0637 \u0627\u0644\u0645\u062a\u063a\u064a\u0631 \u0627\u0644\u062c\u064a\u0646\u064a \u0628\u0645\u0631\u0636 \u0645\u0639\u064a\u0646 \u060c \u0641\u064a\u0645\u0643\u0646 \u062a\u0642\u062f\u064a\u0645 \u0647\u0630\u0647 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0625\u0644\u0649 ClinVar. <\/p>\n\n<p>\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 ClinVar \u0642\u0648\u064a \u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u0642\u062f \u064a\u0628\u062f\u0648 \u0641\u064a \u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0623\u062d\u064a\u0627\u0646 \u063a\u064a\u0631 \u0639\u0645\u0644\u064a \u0648\u064a\u0635\u0639\u0628 \u0627\u0644\u062a\u0646\u0642\u0644 \u0641\u064a\u0647. \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u064a \u062a\u0639\u0644\u0645 \u0643\u064a\u0641\u064a\u0629 \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u0641\u0639\u0627\u0644 \u0645\u0646 \u062e\u0644\u0627\u0644 \u0627\u0644\u0645\u0648\u0642\u0639 \u0625\u0644\u0649 \u0641\u062a\u062d \u0627\u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u0625\u0636\u0627\u0641\u064a\u0629 \u0645\u0646 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0643.<\/p>\n\n<p>\u0641\u064a \u062c\u0648\u0647\u0631\u0647 \u060c \u064a\u0645\u0643\u0646\u0643 \u0627\u0644\u0628\u062d\u062b \u0645\u0646 \u062e\u0644\u0627\u0644 ClinVar \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0623\u064a \u0645\u0646 3 \u0623\u062c\u0632\u0627\u0621 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a. \u0648\u0647\u0630\u0647 \u0647\u064a:<\/p>\n\n<ul class=\"wp-block-list\"><li>\u0645\u0639\u0631\u0641 SNP<\/li><li>\u0627\u0644\u062c\u064a\u0646<\/li><li>\u0627\u0644\u0645\u0631\u0636 \/ \u0627\u0644\u062d\u0627\u0644\u0629<\/li><\/ul>\n\n<h3 class=\"wp-block-heading\"><strong>\u064a\u0628\u062d\u062b<\/strong> \u0643\u0644\u064a\u0646\u0641\u0627\u0631<strong> \u0628\u0648\u0627\u0633\u0637\u0629 SNP<\/strong><\/h3>\n\n<p>\u064a\u062a\u0645 \u062a\u0639\u064a\u064a\u0646 \u0645\u0639\u0631\u0641 \u0641\u0631\u064a\u062f \u0644\u0645\u0639\u0638\u0645 SNPs \u060c \u064a\u0628\u062f\u0623 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0628\u0627\u0644\u0623\u062d\u0631\u0641 &#8220;rs&#8221; \u062b\u0645 \u0633\u0644\u0633\u0644\u0629 \u0645\u0646 \u0627\u0644\u0623\u0631\u0642\u0627\u0645 (\u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u060c rs7412). \u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0624\u062f\u064a \u0625\u062f\u062e\u0627\u0644 \u0647\u0630\u0627 \u0627\u0644\u0645\u0639\u0631\u0641 \u0625\u0644\u0649 \u062a\u0648\u0635\u064a\u0644\u0643 \u0645\u0628\u0627\u0634\u0631\u0629 \u0628\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062d\u0648\u0644 \u0645\u0648\u0642\u0639 SNP \u0648\u0623\u064a \u0623\u0645\u0631\u0627\u0636 \u0642\u062f \u062a\u0643\u0648\u0646 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0647 \u0648\u063a\u064a\u0631 \u0630\u0644\u0643 \u0627\u0644\u0643\u062b\u064a\u0631. <\/p>\n\n<p>\u062a\u062d\u062a\u0648\u064a \u0645\u0644\u0641\u0627\u062a DNA \u0627\u0644\u062e\u0627\u0645 \u0628\u063a\u0636 \u0627\u0644\u0646\u0638\u0631 \u0639\u0646 \u0627\u0644\u062a\u0646\u0633\u064a\u0642 \u0628\u0634\u0643\u0644 \u0639\u0627\u0645 \u0639\u0644\u0649 \u0642\u0627\u0626\u0645\u0629 \u0628\u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0648\u0645\u0639\u0631\u0641\u0627\u062a\u0647\u0627. \u0641\u064a Nebula Genomics \u060c \u0646\u0642\u062f\u0645 \u0644\u0645\u0633\u062a\u062e\u062f\u0645\u064a\u0646\u0627 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0628\u062a\u0646\u0633\u064a\u0642 VCF \u060c \u0648\u0647\u0648 \u0627\u0644\u062a\u0646\u0633\u064a\u0642 \u0627\u0644\u0623\u0643\u062b\u0631 \u0627\u0633\u062a\u062e\u062f\u0627\u0645\u064b\u0627. \u0644\u0641\u062d\u0635 \u0627\u0644\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0643 \u060c \u064a\u0645\u0643\u0646\u0643 \u0645\u0644\u0641 VCF \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u062d\u0631\u0631 \u0646\u0635\u0648\u0635 \u0645\u062b\u0644 Sublime \u0623\u0648 \u0645\u062c\u0631\u062f \u0625\u0644\u0642\u0627\u0621 \u0646\u0638\u0631\u0629 \u0639\u0644\u0649 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0641\u064a \u0645\u0643\u062a\u0628\u0629 Nebula. \u062d\u062a\u0649 \u0627\u0644\u0622\u0646 \u060c \u0642\u0645\u0646\u0627 \u0628\u0627\u0644\u0641\u0639\u0644 \u0628\u062a\u062d\u0644\u064a\u0644 \u0623\u0643\u062b\u0631 \u0645\u0646 8000 \u0645\u062a\u063a\u064a\u0631 \u062c\u064a\u0646\u064a \u060c \u0648\u064a\u062a\u0645 \u0625\u0636\u0627\u0641\u0629 \u062f\u0631\u0627\u0633\u0627\u062a \u0648\u0645\u062a\u063a\u064a\u0631\u0627\u062a \u062c\u062f\u064a\u062f\u0629 \u0643\u0644 \u0623\u0633\u0628\u0648\u0639!<\/p>\n\n<p>\u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 \u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0646\u0638\u0645 SNP \u0645\u0639\u064a\u0646 \u060c \u062f\u0639\u0646\u0627 \u0646\u0633\u062a\u062e\u062f\u0645 ClinVar. \u0644\u0646\u0628\u062f\u0623 \u0628\u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644 \u0625\u0644\u0649<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/\"> \u0627\u0644\u0645\u0648\u0642\u0639<\/a> \u060c \u062d\u064a\u062b \u064a\u062c\u0628 \u0623\u0646 \u062a\u0628\u062f\u0648 \u0627\u0644\u0635\u0641\u062d\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0628\u0647\u0630\u0627 \u0627\u0644\u0634\u0643\u0644:<\/p>\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"889\" height=\"610\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/06\/pasted-image-0-5.png\" alt=\"&#x627;&#x644;&#x635;&#x641;&#x62D;&#x629; &#x627;&#x644;&#x631;&#x626;&#x64A;&#x633;&#x64A;&#x629; &#x644;&#x640; ClinVar.\" class=\"wp-image-15932\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/06\/pasted-image-0-5.png 889w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/06\/pasted-image-0-5-300x206.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/06\/pasted-image-0-5-768x527.png 768w\" sizes=\"(max-width: 889px) 100vw, 889px\" \/><figcaption>\u0627\u0644\u0635\u0641\u062d\u0629 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u0644\u0640 ClinVar.<\/figcaption><\/figure>\n\n<p>\u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0648\u0642\u0639 \u060c \u064a\u0645\u0643\u0646\u0643 \u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 ClinVar \u0648\u0643\u064a\u0641\u064a\u0629 \u062a\u0642\u062f\u064a\u0645 \u0637\u0644\u0628\u0627\u062a \u062c\u062f\u064a\u062f\u0629. \u0625\u0630\u0627 \u0643\u0627\u0646 \u0644\u062f\u064a\u0643 \u0628\u0627\u0644\u0641\u0639\u0644 SNP \u0641\u064a \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 \u060c \u0641\u064a\u0645\u0643\u0646\u0643 \u0628\u0628\u0633\u0627\u0637\u0629 \u0625\u062f\u062e\u0627\u0644\u0647 \u0641\u064a \u0634\u0631\u064a\u0637 \u0627\u0644\u0628\u062d\u062b \u0648\u0627\u0644\u0636\u063a\u0637 \u0639\u0644\u0649 &#8220;\u0628\u062d\u062b&#8221;. \u0647\u0646\u0627 \u060c \u0646\u062d\u0646 \u0645\u0647\u062a\u0645\u0648\u0646 \u0628\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 SNP rs63750048.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh4.googleusercontent.com\/rVEnX3c8stH_lc1CNqV310I_0zzixvh7IKcsArk3PKRW2YgNM6vujTsUXyG3NkSkhIX8K_sZ7Tbn6ob-jMRT-w75B-Rv3d0hQdRf6frdiMF-qhJuJqkxfHJK7ftEYtgzIczdGJtU\" alt=\"&#x628;&#x62D;&#x62B; ClinVar.\"\/><\/figure>\n\n<p>\u0625\u0630\u0627 \u062a\u0645 \u062a\u062d\u0645\u064a\u0644 \u0623\u064a \u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062d\u0648\u0644 SNP \u0625\u0644\u0649 ClinVar \u060c \u0641\u0633\u064a\u0639\u0631\u0636 \u0627\u0644\u0645\u0648\u0642\u0639 \u0646\u062a\u064a\u062c\u0629 \u0628\u062d\u062b \u0639\u0646 SNP \u0647\u0630\u0627. \u064a\u0645\u0643\u0646\u0646\u0627 \u0623\u0646 \u0646\u0631\u0649 \u0641\u064a \u0644\u0645\u062d\u0629 \u0633\u0631\u064a\u0639\u0629 \u0623\u0646\u0647 \u064a\u0642\u0639 \u0641\u064a \u062c\u064a\u0646 \u064a\u0633\u0645\u0649 PSEN2 \u0648\u0642\u062f \u062a\u0645 \u0631\u0628\u0637\u0647 \u0628\u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 4. \u0628\u0627\u0644\u0636\u063a\u0637 \u0639\u0644\u0649 \u0627\u0644\u0631\u0627\u0628\u0637 (\u0627\u0644\u0645\u0648\u0636\u062d \u0641\u064a \u0627\u0644\u0635\u0648\u0631\u0629) \u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 SNP.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/pN75qRjFcWF5Qi3rQemejWNRwNFJc6lwLy2Bj41ZCFnFB8cW9MsZdpkfAbPSuWHX4L94sV6CR8VuYo-ivc_HfuS00UFkGq2M3V9QFLaJX2IizL_jcrMwK8DgRaUKeTHSraL2iTYz\" alt=\"\"\/><figcaption>\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0628\u062d\u062b.<\/figcaption><\/figure>\n\n<p>\u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u0635\u0641\u062d\u0629 \u060c \u064a\u062a\u0645 \u062a\u0648\u0641\u064a\u0631 \u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062d\u0648\u0644 SNP \u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u062c\u0645\u064a\u0639 \u0627\u0644\u0634\u0631\u0648\u0637 \u0627\u0644\u062a\u064a \u0642\u062f \u062a\u0643\u0648\u0646 \u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0647\u0627 \u060c \u0648\u0623\u064a \u0645\u0646\u0634\u0648\u0631\u0627\u062a \u0639\u0644\u0645\u064a\u0629 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 SNP. \u0644\u0643\u0644 \u062d\u0627\u0644\u0629 \u0641\u064a \u0642\u0633\u0645 &#8220;\u0627\u0644\u062a\u0641\u0633\u064a\u0631\u0627\u062a \u0648\u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0645\u0642\u062f\u0645\u0629&#8221; \u060c \u064a\u0645\u0643\u0646\u0643 \u0627\u0644\u0646\u0642\u0631 \u0641\u0648\u0642 \u0631\u0627\u0628\u0637 &#8220;\u062a\u0641\u0627\u0635\u064a\u0644 \u0627\u0644\u062f\u0644\u064a\u0644&#8221; \u0644\u0645\u0639\u0631\u0641\u0629 \u0643\u064a\u0641\u064a\u0629 \u0627\u0631\u062a\u0628\u0627\u0637 SNP \u0628\u0627\u0644\u0645\u0631\u0636 \u0648\u0643\u064a\u0641 \u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641\u0647.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/DrRDZM_b5NmZdK1mFtM2QpDQKXtZBRyELTe5ZbgHLtDL88o8dtp84etXtYFofbUW7eCShefsR6AM8HS_xRm-ctUFSLzTPGKuFjkyJ54r-JjQMSeQijw7b_BSbb9fMVkJ_Oi_faLN\" alt=\"&#x62F;&#x62E;&#x648;&#x644; &#x641;&#x64A; ClinVar.\"\/><figcaption>\u062f\u062e\u0648\u0644 \u0641\u064a ClinVar.<\/figcaption><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh6.googleusercontent.com\/LvPjg1UTxkVLHLPGvNU52zPTcGhjcsBWHh03q6ICUshVmGWbbgu745BVw0u15cQiw2r82c-9KLyiL9O9ufgfeIJ7PMo7fY_BaIJVg3LZZ98DcF-df2BuUjCg609DuGBi1qxH7IxX\" alt=\"&#x627;&#x644;&#x62F;&#x644;&#x64A;&#x644; &#x641;&#x64A; ClinVar.\"\/><figcaption>\u0627\u0644\u062f\u0644\u064a\u0644 \u0641\u064a ClinVar.<\/figcaption><\/figure>\n\n<p>\u0647\u0646\u0627 \u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u0623\u0646 \u0646\u0631\u0649 \u0623\u0646\u0647 \u062a\u0645 \u062a\u062d\u062f\u064a\u062f SNP \u0641\u064a \u0639\u0627\u0626\u0644\u0629 \u0625\u064a\u0637\u0627\u0644\u064a\u0629 \u0645\u0635\u0627\u0628\u0629 \u0628\u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631. \u0627\u0644\u062d\u0631\u0641 \u0627\u0644\u0637\u0628\u064a\u0639\u064a \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0648\u0642\u0639 \u0645\u0646 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0647\u0648 C \u060c \u0644\u0643\u0646 \u0627\u0644\u0627\u062e\u062a\u0628\u0627\u0631\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u064a\u062a \u0639\u0644\u0649 \u0647\u0630\u0647 \u0627\u0644\u0639\u0627\u0626\u0644\u0629 \u062a\u0638\u0647\u0631 \u0623\u0646 \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0639\u0636\u0627\u0621 \u0644\u062f\u064a\u0647\u0645 T \u0641\u064a \u0646\u0641\u0633 \u0627\u0644\u0645\u0648\u0642\u0639 \u060c \u0645\u0645\u0627 \u0642\u062f \u064a\u0624\u062b\u0631 \u0639\u0644\u0649 \u0643\u064a\u0641\u064a\u0629 \u0639\u0645\u0644 \u062c\u064a\u0646 PSEN2. \u064a\u062a\u0627\u0628\u0639 \u0627\u0644\u062a\u0642\u0631\u064a\u0631 \u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0644\u0623\u0639\u0631\u0627\u0636 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0627\u0644\u062a\u064a \u0639\u0627\u0646\u0649 \u0645\u0646\u0647\u0627 \u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0623\u0633\u0631\u0629.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/gV4-x1TLWVuTRO8HsWU-osywaMaX5o74weDeDBQJl_UIuX1J0iDq6LijwaKA9-ODS7O87ximpu2pIu65sMZ5rU9xMl01d8pNvafrrBwJ4wu3q8Fw_rpgMZedtcew3R2U7st_q2U3\" alt=\"&#x62F;&#x644;&#x64A;&#x644; &#x645;&#x641;&#x635;&#x644; &#x641;&#x64A; ClinVar.\"\/><figcaption>\u062f\u0644\u064a\u0644 \u0645\u0641\u0635\u0644 \u0641\u064a ClinVar.<\/figcaption><\/figure>\n\n<h3 class=\"wp-block-heading\"><strong>\u0627\u0644\u0628\u062d\u062b \u0641\u064a ClinVar \u0628\u0627\u0644\u062c\u064a\u0646\u0627\u062a<\/strong><\/h3>\n\n<p>\u0631\u0628\u0645\u0627 \u0644\u0627 \u0646\u0636\u0639 \u0641\u064a \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 SNP \u0645\u0639\u064a\u0646\u064b\u0627 \u060c \u0648\u0646\u0648\u062f \u0628\u062f\u0644\u0627\u064b \u0645\u0646 \u0630\u0644\u0643 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 \u062c\u0645\u064a\u0639 SNPs \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0641\u064a \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0630\u064a \u0646\u0647\u062a\u0645 \u0628\u0647. \u0628\u0645\u062c\u0631\u062f \u0623\u0646 \u0646\u062c\u062f SNP \u0645\u062b\u064a\u0631\u064b\u0627 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0644\u0639\u0648\u062f\u0629 \u0625\u0644\u0649 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u064a\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0646\u0627 \u0648\u0627\u0644\u062a\u062d\u0642\u0642 \u0645\u0646 \u062d\u0627\u0644\u0629 SNP. <\/p>\n\n<p>\u0627\u0628\u062f\u0623 \u0628\u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u0631\u0629 \u0623\u062e\u0631\u0649 \u0625\u0644\u0649 \u0635\u0641\u062d\u0629 ClinVar \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 \u060c \u0648\u0627\u0628\u062d\u062b \u0639\u0646 \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0630\u064a \u062a\u0647\u062a\u0645 \u0628\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646\u0647. \u0641\u064a \u0647\u0630\u0647 \u0627\u0644\u062d\u0627\u0644\u0629 \u060c \u0646\u0628\u062d\u062b \u0639\u0646 &#8220;BRCA&#8221; \u060c \u0648\u0647\u0648 \u062c\u064a\u0646 \u062a\u0645 \u0631\u0628\u0637 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641\u0627\u062a \u0641\u064a\u0647 \u0628\u0632\u064a\u0627\u062f\u0629 \u062e\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh6.googleusercontent.com\/CAKjGzX8dKzfChstnyrWwhkReo19-_JlDcF1Ob4i5G4VzuBGjHgnjV0kXaxp0qKM7FATZ3Xc0AHpv3b-D6X72PSc07KqTP23KhUpu382Iy5XatXm96apbWXxNjhMfB37cX2VaLTU\" alt=\"ClinVar &#x627;&#x644;&#x628;&#x62D;&#x62B; &#x639;&#x646; &#x637;&#x631;&#x64A;&#x642; &#x627;&#x633;&#x645; &#x627;&#x644;&#x62C;&#x64A;&#x646;.\"\/><figcaption>ClinVar \u0627\u0644\u0628\u062d\u062b \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646.<\/figcaption><\/figure>\n\n<p>\u064a\u0624\u062f\u064a \u0627\u0644\u0628\u062d\u062b \u0641\u064a \u0627\u0633\u0645 \u0627\u0644\u062c\u064a\u0646 \u0647\u0630\u0627 \u0625\u0644\u0649 \u0625\u0631\u062c\u0627\u0639 \u0645\u0626\u0627\u062a \u0645\u062a\u063a\u064a\u0631\u0627\u062a ClinVar. \u0628\u0639\u0636\u0647\u0627 \u0645\u0648\u062c\u0648\u062f \u0641\u064a \u062c\u064a\u0646\u0627\u062a BRCA \u0648\u0627\u0644\u0628\u0639\u0636 \u0627\u0644\u0622\u062e\u0631 \u0641\u064a \u062c\u064a\u0646\u0627\u062a \u0645\u0631\u062a\u0628\u0637\u0629 \u0627\u0631\u062a\u0628\u0627\u0637\u064b\u0627 \u0648\u062b\u064a\u0642\u064b\u0627 \u0628\u0640 BRCA. \u0644\u062a\u062c\u0646\u0628 \u0625\u063a\u0631\u0627\u0642 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0628\u062d\u062b \u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u062a\u0635\u0641\u064a\u062a\u0647\u0627 \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u062e\u064a\u0627\u0631\u0627\u062a \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0623\u0633\u0641\u0644 \u0627\u0644\u062c\u0627\u0646\u0628 \u0627\u0644\u0623\u064a\u0633\u0631 \u0645\u0646 \u0627\u0644\u0635\u0641\u062d\u0629. \u0648\u062a\u0634\u0645\u0644 \u0647\u0630\u0647:<\/p>\n\n<ul class=\"wp-block-list\"><li>\u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629: \u0647\u0644 \u064a\u0633\u0628\u0628 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0647\u0630\u0627 \u0645\u0631\u0636\u064b\u0627 \u0645\u0639\u064a\u0646\u064b\u0627 (\u0645\u0633\u0628\u0628 \u0644\u0644\u0623\u0645\u0631\u0627\u0636 \u0648\u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0645\u0633\u0628\u0628\u064b\u0627 \u0644\u0644\u0623\u0645\u0631\u0627\u0636) \u0623\u0645 \u0644\u0627 (\u062d\u0645\u064a\u062f \u0648\u0631\u0628\u0645\u0627 \u062d\u0645\u064a\u062f)\u061f \u0623\u0645 \u0623\u0646\u0647 \u063a\u064a\u0631 \u0645\u0624\u0643\u062f \u0645\u0627 \u0647\u064a \u0622\u062b\u0627\u0631\u0647\u061f \u0623\u0645 \u0623\u0646 \u0647\u0646\u0627\u0643 \u0646\u062a\u0627\u0626\u062c \u0645\u062a\u0636\u0627\u0631\u0628\u0629 \u0645\u0646 \u062f\u0631\u0627\u0633\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629\u061f<\/li><li>\u0627\u0644\u0639\u0648\u0627\u0642\u0628 \u0627\u0644\u062c\u0632\u064a\u0626\u064a\u0629: \u0645\u0627 \u0647\u0648 \u062a\u0623\u062b\u064a\u0631 SNP \u0639\u0644\u0649 \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0646\u061f<\/li><li>\u0646\u0648\u0639 \u0627\u0644\u0627\u062e\u062a\u0644\u0627\u0641: \u0647\u0644 \u062a\u0645 \u0625\u0636\u0627\u0641\u0629 \u062d\u0631\u0641 \u0625\u0644\u0649 \u0627\u0644\u062a\u0633\u0644\u0633\u0644 \u0623\u0645 \u062d\u0630\u0641 \u0645\u0646\u0647\u061f \u0623\u0645 \u0623\u0646\u0647 \u062a\u0645 \u0627\u0633\u062a\u0628\u062f\u0627\u0644 \u062d\u0631\u0641 \u0628\u0622\u062e\u0631 (\u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u060c C \u0625\u0644\u0649 T)\u061f<\/li><li>\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u0631\u0627\u062c\u0639\u0629: \u0645\u0627 \u0645\u0642\u062f\u0627\u0631 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u0645\u0648\u062c\u0648\u062f\u0629 \u0639\u0644\u0649 SNP \u0647\u0630\u0627\u061f<\/li><\/ul>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh4.googleusercontent.com\/oSFLs5QXaltkbxgATCBWTnxeiuEoB29wNYdrFhTkJyn1L9h7fXqzX-TZek5vgLrvQfrjuumTzWPXe2AJxo-Z62hcIyX3rlVRBYDi3oaj2qAdrGELa-EGgWRmrtDnpoC0WUO5TPK4\" alt=\"&#x645;&#x631;&#x634;&#x62D;&#x627;&#x62A; ClinVar.\"\/><figcaption>\u0645\u0631\u0634\u062d\u0627\u062a ClinVar.<\/figcaption><\/figure>\n\n<p>\u0628\u0639\u062f \u0627\u0644\u0627\u0637\u0644\u0627\u0639 \u0639\u0644\u0649 \u062a\u0639\u062f\u062f \u0623\u0634\u0643\u0627\u0644 \u062a\u0639\u062f\u062f \u0627\u0644\u0623\u0634\u0643\u0627\u0644 \u0641\u064a \u0645\u0631\u0634\u062d\u0627\u062a \u0645\u062e\u062a\u0644\u0641\u0629 \u060c \u062f\u0639\u0646\u0627 \u0646\u062a\u0639\u0644\u0645 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 \u0627\u0644\u0645\u062a\u063a\u064a\u0631 \u0627\u0644\u0645\u0645\u064a\u0632 \u0628\u0627\u0644\u0645\u0631\u0628\u0639 \u0627\u0644\u0623\u062d\u0645\u0631 \u0623\u062f\u0646\u0627\u0647.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/78hAFJGI6fQ_jMaak1dvClHLcmmWIQLCGWSh5xmFvAUfUlat8uvTPxoYaNGeDJiIfRBaPECXjiVp7LJQuzGnpleCrszq2T2GWIBar2-GWFef9yMM2YUO97QTOlCqu-oBdMhblwKp\" alt=\"\"\/><\/figure>\n\n<p>\u0628\u0627\u062a\u0628\u0627\u0639 \u0627\u0644\u0631\u0627\u0628\u0637 \u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u0639\u0644\u0649 \u0627\u0644\u0641\u0648\u0631 \u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u062d\u0648\u0644 SNP. \u064a\u0645\u0643\u0646\u0646\u0627 \u0623\u0646 \u0646\u0631\u0649 \u0623\u0646 SNP \u0647\u0648 \u062a\u063a\u064a\u064a\u0631 \u0645\u0646 \u0627\u0644\u062d\u0631\u0641 G \u0625\u0644\u0649 \u0627\u0644\u062d\u0631\u0641 C \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 13 \u060c \u0648\u0645\u0646 \u0627\u0644\u0645\u062d\u062a\u0645\u0644 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0645\u0631\u062a\u0628\u0637\u064b\u0627 \u0628\u0632\u064a\u0627\u062f\u0629 \u062e\u0637\u0631 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a. \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0630\u0644\u0643 \u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u0645\u0639\u0631\u0641\u0629 \u0645\u0639\u0631\u0641 SNP (rs81002796).<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh4.googleusercontent.com\/DsNHftykdXCHYdzCnBIZ8UBGpMpAYSKmAaEiX-thYPKsXDW5ax-L3JuNQaehkRC7z32hYvYhUsgsURoH7o4Nd8X5t0vCrIKGyzxO2YVGpUoNRB41TWewiMDEcexld9-b9W6PuyMr\" alt=\"&#x627;&#x644;&#x623;&#x647;&#x645;&#x64A;&#x629; &#x627;&#x644;&#x633;&#x631;&#x64A;&#x631;&#x64A;&#x629; &#x641;&#x64A; ClinVar. \"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/mR-qPI7A-77S1TzjcLVQer8HCoQYvL0reCoUM8aPjta3ajn_UkgEFahfbObb85Wnq22pdZtKQZ02ivk-bcbJHfVfpdgOVcUYxB_U-KQNBOXilkvXvdSP0TTPcrUouOiZjn36P-go\" alt=\"\"\/><figcaption>\u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0641\u064a ClinVar.<\/figcaption><\/figure>\n\n<h3 class=\"wp-block-heading\"><strong>\u0627\u0644\u0628\u062d\u062b \u0641\u064a ClinVar \u062d\u0633\u0628 \u0627\u0644\u0645\u0631\u0636<\/strong><\/h3>\n\n<p>\u0623\u062e\u064a\u0631\u064b\u0627 \u060c \u0625\u0630\u0627 \u0644\u0645 \u064a\u0643\u0646 \u0644\u062f\u064a\u0646\u0627 SNP \u0645\u0639\u064a\u0646 \u0623\u0648 \u062c\u064a\u0646 \u0645\u0639\u064a\u0646 \u0641\u064a \u0627\u0644\u0627\u0639\u062a\u0628\u0627\u0631 \u060c \u0641\u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0644\u0628\u062d\u062b \u0641\u064a \u062c\u0645\u064a\u0639 SNPs \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0631\u0636 \u0645\u0639\u064a\u0646. \u0648\u0625\u0646 \u0644\u0645 \u064a\u0643\u0646 \u0630\u0644\u0643 \u0645\u0637\u0644\u0648\u0628\u064b\u0627 \u060c \u0641\u0625\u0646 \u0625\u0636\u0627\u0641\u0629 \u0645\u0644\u0641[disease\/phenotype] \u064a\u0645\u0643\u0646 \u0623\u0646 \u062a\u0633\u0627\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u0645\u0629 \u0628\u0639\u062f \u0645\u0635\u0637\u0644\u062d \u0627\u0644\u0628\u062d\u062b \u0641\u064a \u0642\u0635\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0639\u0644\u0649 \u0623\u0643\u062b\u0631 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0635\u0644\u0629 \u0628\u0627\u0644\u062d\u0627\u0644\u0629 \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0641\u0642\u0637. \u0639\u0644\u0649 \u0633\u0628\u064a\u0644 \u0627\u0644\u0645\u062b\u0627\u0644 \u060c \u0625\u0630\u0627 \u0643\u0646\u0627 \u0645\u0647\u062a\u0645\u064a\u0646 \u0628\u0627\u0644\u0640 SNPs \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u060c \u0641\u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u0644\u0628\u062d\u062b \u0641\u064a ClinVar \u0628\u0645\u0635\u0637\u0644\u062d &#8220;\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a[disease\/phenotype] &#8220;.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh4.googleusercontent.com\/qw7-PR_j5W9pl7GgTbzuQ0emDun0Vti_qEKMfawcFzjR0An_QSxQBpUa7MyuqtgcBnbd4dOWxCBmFMAERePdJNxS2vdSABdLPNwn7_WV69ZtHEYT4HAU6fAQPy0v8ywvL68mfk3o\" alt=\"&#x627;&#x644;&#x628;&#x62D;&#x62B; ClinVar &#x639;&#x646; &#x637;&#x631;&#x64A;&#x642; &#x627;&#x633;&#x645; &#x627;&#x644;&#x645;&#x631;&#x636;.\"\/><figcaption>\u0627\u0644\u0628\u062d\u062b ClinVar \u0639\u0646 \u0637\u0631\u064a\u0642 \u0627\u0633\u0645 \u0627\u0644\u0645\u0631\u0636.<\/figcaption><\/figure>\n\n<p>\u0646\u0638\u0631\u064b\u0627 \u0644\u0623\u0646\u0647 \u064a\u062a\u0645 \u0625\u0631\u062c\u0627\u0639 \u0622\u0644\u0627\u0641 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u060c \u0641\u0644\u0646\u0642\u0645 \u0628\u062a\u0635\u0641\u064a\u0629 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0644\u0639\u0631\u0636 \u062a\u0644\u0643 &#8220;\u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062e\u0637\u0631&#8221; \u0627\u0644\u0645\u062d\u062f\u062f\u0629 \u0644\u0645\u0631\u0636 \u0627\u0644\u0633\u0643\u0631\u064a \u0641\u0642\u0637. \u0628\u0639\u062f \u0630\u0644\u0643 \u060c \u062f\u0639\u0646\u0627 \u0646\u062a\u0639\u0644\u0645 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 \u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0623\u0648\u0644\u0649.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/SyJZ1K_37zmzgeB_XA7iLRIhAR3QJW-7RNWJc4v3TmwYK_qEhBwK9-B9t4XTU0Uv4lRToqn4teau-3tsGX5PUOFLfobaO5WPJXrJXWkPtoMmkMCGN-lApzBCpsULCK-iBx-YgKX1\" alt=\"&#x639;&#x627;&#x645;&#x644; &#x62A;&#x635;&#x641;&#x64A;&#x629; &#x639;&#x648;&#x627;&#x645;&#x644; &#x627;&#x644;&#x62E;&#x637;&#x631;.\"\/><figcaption>\u0639\u0627\u0645\u0644 \u062a\u0635\u0641\u064a\u0629 \u0639\u0648\u0627\u0645\u0644 \u0627\u0644\u062e\u0637\u0631.<\/figcaption><\/figure>\n\n<p>\u0628\u0627\u062a\u0628\u0627\u0639 \u0627\u0644\u0631\u0627\u0628\u0637 \u060c \u064a\u0645\u0643\u0646\u0646\u0627 \u0645\u0639\u0631\u0641\u0629 \u0623\u0646 SNP \u0647\u0630\u0627 \u0647\u0648 \u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u062d\u0631\u0641 C \u0625\u0644\u0649 G \u0627\u0644\u0645\u0648\u062c\u0648\u062f \u0639\u0644\u0649 \u0627\u0644\u0643\u0631\u0648\u0645\u0648\u0633\u0648\u0645 1 \u0641\u064a \u0627\u0644\u062c\u064a\u0646 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0627\u0633\u0645 PTPN22. \u062a\u0645 \u062a\u062d\u062f\u064a\u062f SNP \u0641\u064a \u0645\u0646\u0634\u0648\u0631 \u0641\u064a \u0639\u0627\u0645 2006.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh6.googleusercontent.com\/43az1kzg9BG0ZQPPFwGMy-v1Up8h2pkhZs6pueCtHB9HoaUdu1jSa8yWWn0OvUgO8zaozubG7B3XXZQxlND7qdLdb4DmootYRTH9NyJ1L-d4rynwlCbquJ1_zRzhcp2MbsJ8773G\" alt=\"\"\/><\/figure>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/EFYrdgoq0wDW9xrCUI5SujdsjxTsckg4RWbiYQ8P2sH5YcYP3cDrBuRpCgqlNG_Zep3Z8MCF5mPHSor9CJKvZH2lIqDVGT4iGjhWBp5KWCbdxTvgKD9W3TqYt5agTbklCMJRGRFV\" alt=\"&#x627;&#x631;&#x62A;&#x628;&#x627;&#x637; &#x628;&#x627;&#x644;&#x623;&#x62F;&#x628;.\"\/><figcaption>\u0627\u0631\u062a\u0628\u0627\u0637 \u0628\u0627\u0644\u0623\u062f\u0628.<\/figcaption><\/figure>\n\n<p>\u0625\u0630\u0627 \u0643\u0646\u0627 \u0645\u0647\u062a\u0645\u064a\u0646 \u0628\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u062d\u0648\u0644 \u0643\u064a\u0641\u064a\u0629 \u0627\u0644\u0639\u062b\u0648\u0631 \u0639\u0644\u0649 SNP \u060c \u0641\u064a\u0645\u0643\u0646\u0646\u0627 \u0627\u062a\u0628\u0627\u0639 \u0631\u0627\u0628\u0637 \u0627\u0644\u0645\u0646\u0634\u0648\u0631 \u0644\u0645\u0639\u0631\u0641\u0629 \u0627\u0644\u0645\u0632\u064a\u062f \u0639\u0646 \u0627\u0644\u062f\u0631\u0627\u0633\u0629.<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/9Aqrlzd1Hnv3O3Nv1NidOAIPd_i9cbEUkf7E6ynbUAOtDkQXBZBMavWfQbSGrf8QlfN74D8cytSqrcg_aW0Ms_3uAZHKrhB8RScR1TzyCiFKOPk87DhFu9_HHZzZaWi9r67MIotn\" alt=\"&#x62F;&#x631;&#x627;&#x633;&#x629; &#x645;&#x631;&#x62A;&#x628;&#x637;&#x629;.\"\/><figcaption>\u062f\u0631\u0627\u0633\u0629 \u0645\u0631\u062a\u0628\u0637\u0629.<\/figcaption><\/figure>\n\n<h2 class=\"wp-block-heading\"><strong>ClinVar \u0642\u0648\u064a. \u0627\u0633\u062a\u062e\u062f\u0645\u0647 \u0628\u062d\u0643\u0645\u0629.<\/strong><\/h2>\n\n<p>\u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0623\u0646 ClinVar \u0639\u0628\u0627\u0631\u0629 \u0639\u0646 \u0642\u0627\u0639\u062f\u0629 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0648\u0633\u0639\u0629 \u062a\u062c\u0645\u0639 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0645\u0646 \u0622\u0644\u0627\u0641 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0645\u062e\u062a\u0628\u0631\u064a\u0629 \u0648\u0627\u0644\u0637\u0628\u064a\u0629 \u060c \u0641\u0645\u0646 \u0627\u0644\u0645\u0647\u0645 \u0645\u0644\u0627\u062d\u0638\u0629 \u0623\u0646 \u0627\u0644\u0623\u062f\u0627\u0629 \u0644\u064a\u0633\u062a \u0645\u0633\u062a\u0634\u0627\u0631\u064b\u0627 \u0648\u0631\u0627\u062b\u064a\u064b\u0627. \u0644\u0645 \u064a\u062a\u0645 \u062a\u0635\u0645\u064a\u0645\u0647 \u0644\u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0645\u0634\u0648\u0631\u0629 \u0627\u0644\u0637\u0628\u064a\u0629 \u0648\u0627\u0644\u062a\u0634\u062e\u064a\u0635\u0627\u062a. \u0625\u0630\u0627 \u0643\u0646\u062a \u062a\u0634\u0643 \u0641\u064a \u0623\u0646 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0627\u0644\u062a\u064a \u0639\u062b\u0631\u062a \u0639\u0644\u064a\u0647\u0627 \u062e\u0644\u0627\u0644 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0628\u062d\u062b \u0627\u0644\u062a\u064a \u0623\u062c\u0631\u064a\u062a\u0647\u0627 \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0642\u0639 \u0642\u062f \u062a\u0643\u0648\u0646 \u0630\u0627\u062a \u0635\u0644\u0629 \u0628\u0635\u062d\u062a\u0643 \u060c \u0641\u0645\u0646 \u0627\u0644\u0645\u0647\u0645 \u0623\u0646 \u062a\u0631\u0649 \u0637\u0628\u064a\u0628\u064b\u0627 \u0623\u0648 \u0623\u062e\u0635\u0627\u0626\u064a \u0631\u0639\u0627\u064a\u0629 \u0635\u062d\u064a\u0629 \u0645\u0631\u062e\u0635\u064b\u0627 \u0622\u062e\u0631 \u0644\u0644\u0627\u0633\u062a\u0634\u0627\u0631\u0629 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u0629.<\/p>\n\n<p>\u0647\u0644 \u0623\u0639\u062c\u0628\u0643 \u0628\u0631\u0646\u0627\u0645\u062c ClinVar \u0627\u0644\u062a\u0639\u0644\u064a\u0645\u064a \u0627\u0644\u062e\u0627\u0635 \u0628\u0646\u0627\u061f \u0642\u062f \u062a\u062c\u062f \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0648\u0633 \u0645\u0641\u064a\u062f\u0629 \u0623\u064a\u0636\u064b\u0627:<\/p>\n\n<ul class=\"wp-block-list\"><li>\u0643\u064a\u0641\u064a\u0629 \u062a\u0646\u0632\u064a\u0644 \u0645\u0644\u0641<a href=\"https:\/\/nebula.org\/blog\/ar\/23andme-%d8%aa%d8%b3%d8%ac%d9%8a%d9%84-%d8%a7%d9%84%d8%af%d8%ae%d9%88%d9%84\/\"> 23 \u0648 \u0645\u064a<\/a> \u0648<a href=\"https:\/\/nebula.org\/blog\/ar\/%d8%a7%d9%84%d9%86%d8%b3%d8%a8-%d8%aa%d8%b3%d8%ac%d9%8a%d9%84-%d8%a7%d9%84%d8%af%d8%ae%d9%88%d9%84\/\"> \u0627\u0644\u0646\u0633\u0628<\/a> \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a\u061f<\/li><li>\u0643\u064a\u0641 \u062a\u0633\u062a\u0639\u0645\u0644<a href=\"https:\/\/nebula.org\/blog\/ar\/gedmatch-%d8%aa%d8%b9%d9%84%d9%8a%d9%85%d9%8a\/\"> GEDmatch<\/a> \u061f<\/li><li>\u0643\u064a\u0641\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0645\u0644\u0641<a href=\"https:\/\/nebula.org\/blog\/ar\/%d9%85%d9%83%d8%aa%d8%a8%d8%a9-%d8%a7%d9%84%d8%b3%d8%af%d9%8a%d9%85-%d9%81%d8%aa%d8%ad-%d9%81%d8%aa%d8%ad-%d8%a7%d9%84%d8%a8%d8%ad%d8%ab-%d8%a7%d9%84%d8%ac%d9%8a%d9%86%d9%8a\/\"> \u0645\u0643\u062a\u0628\u0629 \u0627\u0644\u0633\u062f\u064a\u0645<\/a> \u061f<\/li><li>\u0643\u064a\u0641<a href=\"https:\/\/nebula.org\/blog\/ar\/%d9%83%d9%8a%d9%81-%d8%aa%d8%a8%d8%af%d8%a3-%d8%a7%d8%b3%d8%aa%d9%83%d8%b4%d8%a7%d9%81-%d8%a7%d9%84%d8%a8%d9%8a%d8%a7%d9%86%d8%a7%d8%aa-%d8%a7%d9%84%d8%ac%d9%8a%d9%86%d9%88%d9%85%d9%8a%d8%a9-%d8%a7\/\"> \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0627\u0644\u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062c\u064a\u0646\u0648\u0645\u064a\u0629 \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0643<\/a> \u061f<\/li><li>\u0643\u064a\u0641<a href=\"https:\/\/nebula.org\/blog\/ar\/%d8%a7%d8%ae%d8%aa%d8%a8%d8%a7%d8%b1-%d8%a7%d9%84%d8%a3%d8%a8%d9%88%d8%a9\/\"> \u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u0623\u0628\u0648\u0629<\/a> \u0627\u0644\u0634\u063a\u0644\u061f<\/li><li><a href=\"https:\/\/nebula.org\/blog\/ar\/%d8%a7%d8%ae%d8%aa%d8%a8%d8%a7%d8%b1-%d8%a7%d9%84%d8%ad%d9%85%d8%b6-%d8%a7%d9%84%d9%86%d9%88%d9%88%d9%8a-%d8%a3%d8%ab%d9%86%d8%a7%d8%a1-%d8%a7%d9%84%d8%ad%d9%85%d9%84\/\">\u0627\u062e\u062a\u0628\u0627\u0631 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0623\u062b\u0646\u0627\u0621 \u0627\u0644\u062d\u0645\u0644\u061f<\/a><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u0645\u0627 \u0647\u0648 ClinVar\u061f \u0628\u0627\u0644\u0646\u0633\u0628\u0629 \u0644\u0643\u062b\u064a\u0631 \u0645\u0646 \u0627\u0644\u0646\u0627\u0633 \u060c \u0641\u0625\u0646 \u0627\u0644\u062d\u0635\u0648\u0644 \u0639\u0644\u0649 \u062a\u0633\u0644\u0633\u0644 \u0627\u0644\u062c\u064a\u0646\u0648\u0645 \u0627\u0644\u062e\u0627\u0635 \u0628\u0647\u0645 \u0647\u0648 \u0628\u062f\u0627\u064a\u0629 \u0631\u062d\u0644\u0629 \u0645\u062b\u064a\u0631\u0629. \u0639\u0644\u0649 \u0627\u0644\u0631\u063a\u0645 \u0645\u0646 \u0630\u0644\u0643 \u060c \u063a\u0627\u0644\u0628\u064b\u0627 \u0645\u0627 \u064a\u064f\u062a\u0631\u0643 \u0627\u0644\u0646\u0627\u0633 \u063a\u064a\u0631 \u0645\u062a\u0623\u0643\u062f\u064a\u0646 \u0645\u0646 \u0623\u064a\u0646 \u064a\u0628\u062f\u0623\u0648\u0646 \u0627\u0633\u062a\u0643\u0634\u0627\u0641 \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0647\u0645. \u0644\u0645\u0639\u0631\u0641\u0629 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/ar\/%d9%83%d9%84%d9%8a%d9%86%d9%81%d8%a7%d8%b1-%d8%aa%d8%b9%d9%84%d9%8a%d9%85%d9%8a\/\"> <span class=\"screen-reader-text\">\u0643\u064a\u0641\u064a\u0629 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 ClinVar &#8211; \u0628\u0631\u0646\u0627\u0645\u062c \u062a\u0639\u0644\u064a\u0645\u064a \u0644\u0644\u0645\u0628\u062a\u062f\u0626\u064a\u0646<\/span> \u0627\u0642\u0631\u0623 \u0627\u0644\u0645\u0632\u064a\u062f \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":15931,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[5055],"tags":[],"class_list":["post-15927","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-5055"],"yoast_head":"<!-- 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