{"id":10004,"date":"2021-01-06T00:04:13","date_gmt":"2021-01-06T05:04:13","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-qt-intervall-arking-2014\/"},"modified":"2021-02-20T20:27:51","modified_gmt":"2021-02-21T01:27:51","slug":"genetik-von-qt-intervall-arking-2014","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-qt-intervall-arking-2014\/","title":{"rendered":"QT-Intervall (Arking, 2014)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die genetische Assoziationsstudie des QT-Intervalls zeigt die Rolle der Kalzium-Signalwege bei der Repolarisation des Myokards<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 22 neuen genomischen Regionen, die mit der QT-Intervalldauer assoziiert sind. Dies ist die Zeit, die ein Herz ben\u00f6tigt, um sich f\u00fcr den Schlag wieder aufzuladen. <\/p>\n\n

\u00dcBERBLICK:<\/strong> Jedes Mal, wenn es schl\u00e4gt, wandert eine elektrische Welle durch Ihr Herz. Nach jedem Herzschlag braucht Ihr Herz Zeit, um sich vor dem n\u00e4chsten Herzschlag neu zu polarisieren oder \u201eaufzuladen\u201c. Diese Zeit wird als QT-Intervall bezeichnet. Je l\u00e4nger das QT-Intervall ist, desto l\u00e4nger braucht Ihr Herz, um sich zwischen den Herzschl\u00e4gen aufzuladen. Zu lange Intervalle sind ein Risikofaktor f\u00fcr herzbedingte Erkrankungen wie Herzrhythmusst\u00f6rungen und pl\u00f6tzlichen Herztod. Diese Studie untersuchte die Genome von \u00fcber 100.000 Personen, von denen die meisten europ\u00e4ischer Abstammung waren, um die genetischen Grundlagen der QT-Intervalldauer besser zu verstehen. Die Studie identifizierte 35 mit dem Merkmal assoziierte Genomregionen, von denen 22 neu sind. Mehrere dieser Genomregionen codieren Proteine, die am Kalzium-Signalweg beteiligt sind, was die Bedeutung des Kalzium-Signals f\u00fcr die Wiederaufladung des Herzens hervorhebt. <\/p>\n\n

HAST DU GEWUSST?<\/strong> Die Dauer des QT-Intervalls kann mit einem Elektrokardiogramm (EKG) gemessen werden. Es ist ein \u00fcblicher und schmerzloser Test, der nur etwa f\u00fcnf bis zehn Minuten dauert. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

QT-ASSOZIIERTE VARIANTEN:<\/strong> rs12143842, rs11153730, rs246196, rs7122937, rs2072413, rs846111, rs10919070, rs735951, rs6793245, rs1396515, rs1052536, rs1805128, rs2298632, rs9892651, rs12997023, rs246185, rs3026445, rs3105593, rs295140, rs2273905, rs10040989, rs174583, rs11779860, rs7765828, rs1296720, Rs938291, Rs2363719, Rs3857067, Rs16936870, Rs1961102, Rs7561149, Rs728926, Rs17784882, Rs9920, Rs2485376<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>QT-Intervall (Video)<\/a> Langes QT-Intervall<\/a>Herzleitungsst\u00f6rungen<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 28. April 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die genetische Assoziationsstudie des QT-Intervalls zeigt die Rolle der Kalzium-Signalwege bei der Repolarisation des Myokards ZUSAMMENFASSUNG: Identifizierung von 22 neuen genomischen Regionen, die mit der QT-Intervalldauer assoziiert sind. Dies ist die Zeit, die ein Herz ben\u00f6tigt, um sich f\u00fcr …<\/p>\n

QT-Intervall (Arking, 2014)<\/span> Read More 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