{"id":10013,"date":"2021-01-06T00:04:20","date_gmt":"2021-01-06T05:04:20","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-atopischen-dermatitis-paternoster-2015\/"},"modified":"2021-02-20T20:26:12","modified_gmt":"2021-02-21T01:26:12","slug":"genetik-der-atopischen-dermatitis-paternoster-2015","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-atopischen-dermatitis-paternoster-2015\/","title":{"rendered":"Atopische Dermatitis (Paternoster, 2015)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Eine genomweite Assoziationsstudie mit mehreren Vorfahren von 21.000 F\u00e4llen und 95.000 Kontrollen identifiziert neue Risikostandorte f\u00fcr atopische Dermatitis<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Entdeckung von 10 neuen Genomregionen im Zusammenhang mit atopischer Dermatitis, auch als Ekzem bekannt.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Die Haut ist das gr\u00f6\u00dfte Organ im K\u00f6rper und dient als Barriere f\u00fcr die Au\u00dfenwelt. Das Immunsystem unterst\u00fctzt diese Barrierefunktion und greift \u201efremde\u201c Substanzen an, die mit der Haut in Kontakt kommen. In diesem Fall kann sich die Haut entz\u00fcnden, rot werden und jucken. Atopische Dermatitis (AD), auch als Ekzem bekannt, eine Hautentz\u00fcndung, die durch Umweltfaktoren ausgel\u00f6st wird, die f\u00fcr den K\u00f6rper eigentlich nicht sch\u00e4dlich sind. Zu diesen Faktoren k\u00f6nnen unter anderem Temperatur, Seife und Kleidung geh\u00f6ren. AD ist hoch vererbbar, wobei die Genetik bis zu 90% der Anf\u00e4lligkeit eines Individuums f\u00fcr die Krankheit bestimmt. Um genetische Varianten zu identifizieren, die mit atopischer Dermatitis assoziiert sind, untersuchte diese genomweite Assoziationsstudie \u00fcber 116.000 Personen europ\u00e4ischer, afrikanischer, japanischer und lateinamerikanischer Abstammung. Die Studie fand 21 Regionen des Genoms, die mit atopischer Dermatitis assoziiert sind, von denen 10 neu sind. Insgesamt k\u00f6nnen diese Varianten etwa 15% der Varianz der Anf\u00e4lligkeit f\u00fcr AD erkl\u00e4ren. Zu den neu identifizierten Genomregionen geh\u00f6ren Gene, die am Immunsystem beteiligt sind, insbesondere die Funktion von T-Zellen, die bei vielen Autoimmunerkrankungen eine wichtige Rolle spielen. <\/p>\n\n

HAST DU GEWUSST?<\/strong> Atopische Dermatitis kann eine anhaltende Erkrankung sein, mit periodisch auftretenden Sch\u00fcben. Um die Schwere und H\u00e4ufigkeit der Symptome zu verringern, ist eine gute Hautpflege von entscheidender Bedeutung. Dies beinhaltet die regelm\u00e4\u00dfige Anwendung einer Feuchtigkeitscreme, die Verwendung eines \u201egeruchsfreien\u201c Waschmittels und die Vermeidung von Kratzern auf juckender Haut. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

AD-ASSOZIIERTE VARIANTEN:<\/strong> rs61813875, rs10791824, rs12188917, rs6419573, rs2212434, rs4809219, rs2918307, rs2041733, rs12730935, rs2038255, rs7127307, rs7512552, rs6473227, r4<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Atopische Dermatitis (Video)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 28. April 2020<\/p>\n\n

Schauen Sie sich auch unsere an \u00dcberpr\u00fcfung der Kurologie<\/a> !<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Eine genomweite Assoziationsstudie mit mehreren Vorfahren von 21.000 F\u00e4llen und 95.000 Kontrollen identifiziert neue Risikostandorte f\u00fcr atopische Dermatitis ZUSAMMENFASSUNG: Entdeckung von 10 neuen Genomregionen im Zusammenhang mit atopischer Dermatitis, auch als Ekzem bekannt. \u00dcBERBLICK: Die Haut ist das gr\u00f6\u00dfte …<\/p>\n

Atopische Dermatitis (Paternoster, 2015)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6281,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10013","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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