{"id":10029,"date":"2021-01-06T00:05:51","date_gmt":"2021-01-06T05:05:51","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-lvesv-pirruccello-2020\/"},"modified":"2021-02-20T20:28:53","modified_gmt":"2021-02-21T01:28:53","slug":"genetik-von-lvesv-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-lvesv-pirruccello-2020\/","title":{"rendered":"Linksventrikul\u00e4res end-systolisches Volumen (Pirruccello, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 28 genetischen Varianten, die mit dem linksventrikul\u00e4ren end-systolischen Volumen (LVESV) assoziiert sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Das menschliche Herz ist ein Muskel, der Blut durch den K\u00f6rper pumpt. Es besteht aus 4 Kammern: 2 Vorh\u00f6fe (links und rechts) und 2 Ventrikel (links und rechts). Mit Sauerstoff angereichertes Blut in der Lunge gelangt in das linke Atrium und flie\u00dft dann in den linken Ventrikel, von wo es in alle anderen K\u00f6rperteile gepumpt wird. Das linksventrikul\u00e4re end-systolische Volumen (LVESV) ist das Blutvolumen, das am Ende einer Pumpe im linken Ventrikel verbleibt. Der durchschnittliche LVESV betr\u00e4gt 41 ml f\u00fcr Frauen und 58 ml f\u00fcr M\u00e4nner und kann als Ma\u00df f\u00fcr die Herzgesundheit verwendet werden. Diese genomweite Assoziationsstudie untersuchte die Genome von 36.000 Personen europ\u00e4ischer Abstammung, um die genetischen Grundlagen von LVESV besser zu verstehen. Die Studie identifizierte 28 mit LVESV assoziierte Genomregionen, angepasst an die K\u00f6rperoberfl\u00e4che. Die Studie fand auch heraus, dass ein hoher polygener Score f\u00fcr das an die K\u00f6rperoberfl\u00e4che angepasste LVESV stark mit dem Risiko einer dilatativen Kardiomyopathie korreliert. Dieser Zustand beschreibt einen Herzmuskel, der zu gedehnt und d\u00fcnn ist und nicht effizient pumpen kann.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Der Ausdruck \u201eLachen ist die beste Medizin\u201c hat etwas Wahres. Lachen kann sich positiv auf Ihre Herzgesundheit auswirken, da sich die Arterien entspannen und flexibler werden und die Durchblutung erleichtert wird. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

LVESV-ASSOZIIERTE VARIANTEN:<\/strong> rs72840788, rs945425, rs2562845, rs73028849, rs5760061, rs3176326, rs10421891, rs12452367, rs34373805, rs8063213, rs79502300, rs1962104, rs11023059, rs189569984, rs9892651, rs1499813, rs2302455, rs11748963, rs10871753, rs116904997, rs190093681, rs709208, rs2886037, rs242562<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Das Herz (Video)<\/a>Wie das Herz funktioniert<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Linksventrikul\u00e4re Ejektionsfraktion (Pirruccello, 2020)<\/a> Linksventrikul\u00e4res enddiastolisches Volumen (Pirruccello, 2020)<\/a>Schlagvolumen (Pirruccello, 2020)<\/a>Herzinsuffizienz (Shah, 2020)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 19. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie ZUSAMMENFASSUNG: Identifizierung von 28 genetischen Varianten, die mit dem linksventrikul\u00e4ren end-systolischen Volumen (LVESV) assoziiert sind. \u00dcBERBLICK: Das menschliche Herz ist ein Muskel, der Blut …<\/p>\n

Linksventrikul\u00e4res end-systolisches Volumen (Pirruccello, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6376,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10029","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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