{"id":10037,"date":"2021-01-06T00:05:56","date_gmt":"2021-01-06T05:05:56","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-lungen-adenokarzinom-mckay-2017\/"},"modified":"2021-02-20T20:21:14","modified_gmt":"2021-02-21T01:21:14","slug":"genetik-lungen-adenokarzinom-mckay-2017","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-lungen-adenokarzinom-mckay-2017\/","title":{"rendered":"Lungenadenokarzinom (McKay, 2017)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Eine gro\u00df angelegte Assoziationsanalyse identifiziert neue Anf\u00e4lligkeitsorte f\u00fcr Lungenkrebs und Heterogenit\u00e4t der genetischen Anf\u00e4lligkeit \u00fcber histologische Subtypen hinweg<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 6 neuen Genomregionen, die mit Lungenadenokarzinom assoziiert sind. <\/p>\n\n

\u00dcBERBLICK:<\/strong> Lungenkrebs ist eine Erkrankung, bei der sich Zellen in der Lunge unkontrolliert teilen. Das Lungenadenokarzinom ist ein Subtyp, der ~ 40% aller Lungenkrebserkrankungen ausmacht. Es wird durch Mutationen in schleimproduzierenden Dr\u00fcsenzellen der Lunge verursacht. Im Durchschnitt w\u00e4chst das Lungenadenokarzinom langsamer als andere Subtypen von Lungenkrebs. Um die genetischen Grundlagen dieses Krebses besser zu verstehen, untersuchte diese Studie die Genome von ~ 67.000 Personen. Die Forscher identifizierten 6 neue Regionen, die mit Lungenadenokarzinom assoziiert sind. Die H\u00e4lfte dieser Regionen befindet sich in der N\u00e4he von Genen, die mit der Telomerl\u00e4nge zusammenh\u00e4ngen und sich mit dem Alter verk\u00fcrzen. Insgesamt erkl\u00e4ren die identifizierten genetischen Varianten 6,7% der Erblichkeit dieses Krebses. <\/p>\n\n

HAST DU GEWUSST?<\/strong> Die h\u00e4ufigste Art von Lungenkrebs bei Frauen ist das Adenokarzinom. Dar\u00fcber hinaus ist Adenokarzinom am wenigsten mit Rauchen verbunden. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

LUNGEN-ADENOKARZINOM-ASSOZIIERTE VARIANTEN:<\/strong> rs7705526, rs77468143, rs13080835, rs115917190, rs4236709, rs1056562, rs885518, rs41309931<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Lungenkrebs (Video)<\/a>Lungenkrebsarten<\/a>Leben mit Lungenkrebs<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 12. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Eine gro\u00df angelegte Assoziationsanalyse identifiziert neue Anf\u00e4lligkeitsorte f\u00fcr Lungenkrebs und Heterogenit\u00e4t der genetischen Anf\u00e4lligkeit \u00fcber histologische Subtypen hinweg ZUSAMMENFASSUNG: Identifizierung von 6 neuen Genomregionen, die mit Lungenadenokarzinom assoziiert sind. \u00dcBERBLICK: Lungenkrebs ist eine Erkrankung, bei der sich Zellen in …<\/p>\n

Lungenadenokarzinom (McKay, 2017)<\/span> Read More 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