{"id":10042,"date":"2021-01-06T00:06:02","date_gmt":"2021-01-06T05:06:02","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-pr-intervall-ntalla-2020\/"},"modified":"2021-02-20T20:21:34","modified_gmt":"2021-02-21T01:21:34","slug":"genetik-pr-intervall-ntalla-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-pr-intervall-ntalla-2020\/","title":{"rendered":"PR-Intervall (Ntalla, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Das GWAS mit mehreren Vorfahren des elektrokardiographischen PR-Intervalls identifiziert 202 Loci, die der Herzleitung zugrunde liegen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Entdeckung von 202 Regionen des Genoms, die mit der PR-Intervalldauer des Herzens verbunden sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Das Herz schl\u00e4gt in regelm\u00e4\u00dfigen Abst\u00e4nden, um Blut durch den K\u00f6rper zu pumpen. Um das Timing eines Herzschlags zu steuern, ist das Herz auf ein System angewiesen, das elektrische Signale an die Muskelzellen des Herzens sendet. Das Elektrokardiogramm oder EKG ist ein h\u00e4ufig verwendetes medizinisches Verfahren zur Messung der elektrischen Aktivit\u00e4t w\u00e4hrend eines Herzschlags. Das PR-Intervall ist die Zeit zwischen der Aktivierung der Vorh\u00f6fe des Herzens und der Aktivierung der Ventrikel. Eine normale PR-Intervalldauer liegt zwischen 0,12 und 0,20 Sekunden. Eine zu kurze, zu lange oder unregelm\u00e4\u00dfige PR-Intervalldauer kann ein Hinweis auf eine Herzerkrankung sein. Die genomweite Assoziationsstudie untersuchte fast 300.000 Personen europ\u00e4ischer, afrikanischer, hispanischer und brasilianischer Abstammung, um Varianten zu identifizieren, die mit der PR-Intervalldauer des Herzens zusammenh\u00e4ngen. Die Forscher identifizierten 202 Genomregionen, von denen 141 neu sind. Einige der Varianten befinden sich in der N\u00e4he von Genen, die an der Entwicklung und Kontraktion der Herzmuskulatur beteiligt sind. Zusammen k\u00f6nnen die identifizierten Varianten \u00fcber 62% der Heritabilit\u00e4t der PR-Intervalldauer des Herzens erkl\u00e4ren.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Das durchschnittliche menschliche Herz schl\u00e4gt im Ruhezustand zwischen 60 und 100 Mal pro Minute. Das summiert sich auf \u00fcber 100.000 Mal pro Tag! Viele Faktoren beeinflussen die Herzfrequenz, einschlie\u00dflich Fitness, Stress, K\u00f6rpergr\u00f6\u00dfe, Temperatur und Ern\u00e4hrung. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"PR-Intervall-Probenergebnisse\"<\/a><\/figure>\n\n

PR-INTERVALL-ASSOZIIERTE VARIANTEN:<\/strong> rs6801957, rs3807989, rs2624021, rs4246224, rs3891585, rs1124477, rs6730558, rs29795, rs2754171, rs35712872, rs11153730, rs10883908, rs6441111, rs2503715, rs12869776, rs116532272, rs4245338, rs2732814, rs4677294, rs61989382, rs35680304, rs10882644, rs114555443, rs2042995, rs60325252, rs1531447, rs72690486, rs4834347, rs4971089, rs757416, rs17496249, rs10039283, rs340397, rs72671655, rs4975572, rs13131421, rs6795775, rs6442433, rs2004851, rs7394152, rs881299, rs41306688, rs17026114, rs4871397, rs982521, rs6922960, rs1084537, rs6496452, rs3759310, rs763076, rs117443987, rs2137897, rs4687352, rs56352403, rs1692144, rs12443745, rs72825038, rs2070464, rs16989138, rs11921457, rs871728, rs1285678, rs74772720, rs2970854, rs730506, rs35214871, rs7199856, rs12616546, rs74537277, rs3768419, rs4959193, rs57214150, rs1255908, rs13006682, rs4680046, Rs2912774, Rs12751675, Rs4894803, Rs1816959, Rs62441680, Rs4868384, Rs12808601, Rs62008078, Rs17441816, Rs6678632, Rs28414612, Rs4584185, Rs61824886 58577564, rs28468565, rs10862858, rs78810186, rs1015149, rs35006907, rs2629745, rs62003514, rs8039168, rs28634651, rs6560168, rs11894252, rs1188285, rs4519566, rs2625322, rs7146955, rs6023939, rs17099893, rs1769758, rs12961264, rs7972416, rs206708, rs9513995, rs442177, rs11786896, rs10776558, rs3784192, rs55866125, rs603901, rs2004359, rs10770646, rs62472627, rs1786595, rs3795063, rs214502, rs13023533, rs3759579, rs3935716, rs76611452, rs76909456, rs17712080, rs7529220, rs78518764, rs79321945, rs94111, rs4869412, rs67234920, rs28540500, rs1037100, rs12654442, rs12190287, rs287606, rs74813029, rs4720244, rs9865051, rs2947080, rs179145, rs77422711, rs17816356, rs904199, rs111551996, rs7043482, rs12885183, rs7774, rs35816944, rs10106406, rs111739590, rs8904, rs12031946, rs1000368, rs9909004, rs6961768, rs10226357, rs36034102, rs2577531, rs2642608, rs4921804, rs9634754, rs67968533, rs7588761, rs9607805, rs2006122, rs144789148, rs4026608, rs10802580, rs1186818, rs1407243, rs2172448 071, rs7584373, rs13447455, rs819636, rs6728830, rs2179452, rs4545054, rs1475267, rs113394178, rs6800641, rs6587924, rs531706, rs745570, rs531701, rs745570, rs531706<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Das elektrische Leitungssystem des Herzens (Video)<\/a>Was ist ein EKG?<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Schlagvolumen (Pirruccello, 2020)<\/a>QT-Intervall (Arking, 2014)<\/a>Linksventrikul\u00e4re Ejektionsfraktion (Pirruccello, 2020)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 2. Juni 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Das GWAS mit mehreren Vorfahren des elektrokardiographischen PR-Intervalls identifiziert 202 Loci, die der Herzleitung zugrunde liegen ZUSAMMENFASSUNG: Entdeckung von 202 Regionen des Genoms, die mit der PR-Intervalldauer des Herzens verbunden sind. \u00dcBERBLICK: Das Herz schl\u00e4gt in regelm\u00e4\u00dfigen Abst\u00e4nden, um …<\/p>\n

PR-Intervall (Ntalla, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6456,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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