{"id":10072,"date":"2021-01-06T00:06:47","date_gmt":"2021-01-06T05:06:47","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-autoimmun-schilddruesen-krankheit-saevarsdottir-2020\/"},"modified":"2021-02-20T20:29:54","modified_gmt":"2021-02-21T01:29:54","slug":"genetik-der-autoimmun-schilddruesen-krankheit-saevarsdottir-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-autoimmun-schilddruesen-krankheit-saevarsdottir-2020\/","title":{"rendered":"Autoimmunerkrankung der Schilddr\u00fcse (Saevarsdottir, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die FLT3-Stop-Mutation erh\u00f6ht den FLT3-Ligandenspiegel und das Risiko einer Autoimmunerkrankung der Schilddr\u00fcse<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 99 genetischen Varianten im Zusammenhang mit Autoimmunerkrankungen der Schilddr\u00fcse.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Das menschliche Immunsystem hat sich entwickelt, um unseren K\u00f6rper gegen krankheitsverursachende Mikroorganismen zu verteidigen. Manchmal kann das Immunsystem einer Person jedoch die k\u00f6rpereigenen Zellen angreifen und eine Autoimmunerkrankung verursachen. Wenn das Immunsystem die Schilddr\u00fcse, ein bogenf\u00f6rmiges, hormonproduzierendes Organ im Nacken, angreift und zerst\u00f6rt, kann es den Herzschlag verlangsamen, eine Gewichtszunahme verursachen und dazu f\u00fchren, dass es sich kalt, m\u00fcde und depressiv anf\u00fchlt. Diese Studie untersuchte genetische Daten von \u00fcber 30.000 Patienten mit Autoimmunerkrankungen der Schilddr\u00fcse und \u00fcber 700.000 gesunden Kontrollpersonen (europ\u00e4ischer Abstammung) und entdeckte 99 genetische Varianten, von denen 84 neu sind und mit Autoimmunerkrankungen der Schilddr\u00fcse assoziiert sind. Eine der entdeckten Varianten reduziert die Produktion des FLT3-Rezeptors. Als Reaktion darauf produziert der K\u00f6rper mehr Signalmolek\u00fcle, die an das FLT3-Rezeptorprotein binden, was die Funktion des Immunsystems beeintr\u00e4chtigt und das Risiko einer Autoimmunerkrankung der Schilddr\u00fcse erh\u00f6ht.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Die Hashimoto-Krankheit und die Basedow-Krankheit werden beide durch das Immunsystem verursacht, das die Schilddr\u00fcse angreift. Bei der Hashimoto-Krankheit t\u00f6tet das Immunsystem Schilddr\u00fcsenzellen ab, was zu einer verminderten Funktion der Schilddr\u00fcse f\u00fchrt. Bei Morbus Basedow stimuliert das Immunsystem tats\u00e4chlich die Schilddr\u00fcsenzellen, was zu einer \u00dcberproduktion von Schilddr\u00fcsenhormonen f\u00fchrt. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

THYROID DISEASE-ASSOZIIERTE VARIANTEN:<\/strong> rs9272426, rs2476601, rs3184504, rs925489, rs231775, rs371058848, rs654537, rs7568275, rs13080163, rs2757041, rs4409785, rs71508903, rs229527, rs6535628, rs7090530, rs3764022, rs76428106, rs17364832, rs11052754, rs11675342, rs2921071, rs1534430, rs4293777, rs397746317, rs6914622, rs7173565, rs10742340, rs10686842, rs2445610, rs61759532, rs11079788, rs71198528, rs12582330, rs76226393, rs78534766, rs7441808, rs9533118, rs1990760, rs1050976, rs2123340, rs244688, rs34205992, rs6457834, rs34536443, rs35667974, rs4841567, rs61382, rs2069556, rs2745803, rs146750254, rs6867654, rs3775291, rs301802, rs13250295, rs10748781, rs911760, rs9494389, rs9878908, rs926103, rs202157095, rs6505765, rs12117927, rs2271194, rs2234167, rs114378220, rs11714843, rs7831557, rs7251, rs12697352, rs3784099, rs1991797, rs763361, rs2823272, rs1257920, rs11720041, rs11898293, rs2111567, rs61776678, rs1214598, rs9683415, rs4320727, rs111352680, rs7218886, rs72922276, rs12114596, rs7428218, rs221796, rs7758816 4, rs1045216, rs607404, rs12756886, rs1079418, rs7594497, rs12793348, rs1058900, rs35677470, rs8053655, rs2681417<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Hypothyreose vs. Hyperthyreose: Was ist der Unterschied? (Video)<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Schilddr\u00fcsenkrebs (Liyanarachchi, 2020)<\/a>Schilddr\u00fcsenkrebs (Gudmundsson, 2017)<\/a>Sj\u00f6gren-Syndrom (Lessard, 2013)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 3. Juli 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die FLT3-Stop-Mutation erh\u00f6ht den FLT3-Ligandenspiegel und das Risiko einer Autoimmunerkrankung der Schilddr\u00fcse ZUSAMMENFASSUNG: Identifizierung von 99 genetischen Varianten im Zusammenhang mit Autoimmunerkrankungen der Schilddr\u00fcse. \u00dcBERBLICK: Das menschliche Immunsystem hat sich entwickelt, um unseren K\u00f6rper gegen krankheitsverursachende Mikroorganismen zu verteidigen. …<\/p>\n

Autoimmunerkrankung der Schilddr\u00fcse (Saevarsdottir, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6596,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10072","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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