{"id":10099,"date":"2021-01-06T00:07:25","date_gmt":"2021-01-06T05:07:25","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-gallenstein-ferkingstad-2018\/"},"modified":"2021-02-20T20:20:08","modified_gmt":"2021-02-21T01:20:08","slug":"genetik-von-gallenstein-ferkingstad-2018","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-gallenstein-ferkingstad-2018\/","title":{"rendered":"Gallensteine (Ferkingstad, 2018)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die genomweite Assoziations-Metaanalyse ergibt 20 Loci, die mit einer Gallensteinerkrankung assoziiert sind<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Entdeckung von 21 Genomregionen im Zusammenhang mit der Gallensteinbildung. <\/p>\n\n

\u00dcBERBLICK:<\/strong> Die Gallenblase speichert eine Fl\u00fcssigkeit namens Galle. Es gibt Galle in den Darm ab, wo es bei der Verdauung hilft. Galle enth\u00e4lt Gallens\u00e4uren, die im K\u00f6rper aus Cholesterin hergestellt werden. Gallensteine sind Steine, die sich in der Gallenblase bilden k\u00f6nnen, wenn zu viel Cholesterin und zu wenig Gallens\u00e4uren vorhanden sind. Die Steine k\u00f6nnen Schmerzen im oberen rechten Bauch verursachen und m\u00fcssen m\u00f6glicherweise operiert werden. Um die mit der Gallensteinbildung verbundenen genetischen Varianten zu identifizieren, untersuchte diese genomweite Assoziationsstudie die Genome von \u00fcber 750.000 Personen europ\u00e4ischer Herkunft. Die Studie identifizierte 28 Genomregionen im Zusammenhang mit Gallensteinerkrankungen, von denen 21 neu sind. Einige dieser genetischen Varianten wurden zuvor mit Diabetes und Fettstoffwechsel in Verbindung gebracht. <\/p>\n\n

HAST DU GEWUSST?<\/strong> Laut den Guinness-Weltrekorden waren die meisten Gallensteine, die einem Patienten entfernt wurden, ~ 24.000. Im Gegensatz dazu haben die meisten Patienten, die wegen einer Gallensteinerkrankung operiert werden, durchschnittlich 2 bis 20. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

GALLSTONE-ASSOZIIERTE VARIANTEN:<\/strong> rs11887534, rs212100, rs12633863, rs4148808, rs2291428, rs2290846, rs1800961, rs6471717, rs601338, rs686030, rs756082276, rs28929474, rs1260326, rs34851490, rs1169288, rs756935975, rs13280055, rs56398830, rs174567, rs708686, rs11012737, rs1935, rs2469991, rs17240268, rs2070959, rs12004, rs55971546, rs11641445, rs17138478, rs45575636, rs2292553, rs12968116<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Gallensteine (Video)<\/a> Gallensteinkrankheit<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 28. April 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die genomweite Assoziations-Metaanalyse ergibt 20 Loci, die mit einer Gallensteinerkrankung assoziiert sind ZUSAMMENFASSUNG: Entdeckung von 21 Genomregionen im Zusammenhang mit der Gallensteinbildung. \u00dcBERBLICK: Die Gallenblase speichert eine Fl\u00fcssigkeit namens Galle. Es gibt Galle in den Darm ab, wo es …<\/p>\n

Gallensteine (Ferkingstad, 2018)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10099","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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