{"id":10112,"date":"2021-01-06T00:07:36","date_gmt":"2021-01-06T05:07:36","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-des-sjoegrens-syndrom-lessard-2013\/"},"modified":"2021-02-20T20:27:42","modified_gmt":"2021-02-21T01:27:42","slug":"genetik-des-sjoegrens-syndrom-lessard-2013","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-des-sjoegrens-syndrom-lessard-2013\/","title":{"rendered":"Sj\u00f6gren-Syndrom (Lessard, 2013)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Varianten an mehreren Orten, die sowohl an angeborenen als auch an adaptiven Immunantworten beteiligt sind, sind mit dem Sj\u00f6gren-Syndrom assoziiert<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 7 Genomregionen, die mit dem Risiko des Sj\u00f6gren-Syndroms assoziiert sind. <\/p>\n\n

\u00dcBERBLICK:<\/strong> Das Sj\u00f6gren-Syndrom ist eine Autoimmunerkrankung, die durch trockene Augen und trockenen Mund gekennzeichnet ist. Es tritt auf, wenn das k\u00f6rpereigene Immunsystem f\u00e4lschlicherweise Dr\u00fcsen angreift, wie sie Speichel und Tr\u00e4nen produzieren. Infolgedessen entz\u00fcnden sich diese Dr\u00fcsen und werden besch\u00e4digt. Allein in den USA k\u00f6nnen bis zu 3 Millionen Menschen vom Sj\u00f6gren-Syndrom betroffen sein. W\u00e4hrend die Erkrankung Personen in jedem Alter betreffen kann, wird sie am h\u00e4ufigsten bei \u00e4lteren Frauen diagnostiziert. Um die Genetik besser zu verstehen, die eine Person f\u00fcr die Erkrankung pr\u00e4disponieren kann, wurden in dieser genomweiten Assoziationsstudie fast 8.400 Personen europ\u00e4ischer Herkunft untersucht. Die Studie fand 7 Regionen des Genoms, die mit der Anf\u00e4lligkeit f\u00fcr die Entwicklung des Sj\u00f6gren-Syndroms assoziiert sind. In diesen Regionen befindliche Gene spielen eine Rolle f\u00fcr die Funktion des Immunsystems, einschlie\u00dflich der Produktion entz\u00fcndungsf\u00f6rdernder Interferonproteine. Zusammen k\u00f6nnen die identifizierten Varianten einen gro\u00dfen Teil des vererbbaren Risikos f\u00fcr die Erkrankung erkl\u00e4ren. <\/p>\n\n

HAST DU GEWUSST?<\/strong> Betroffene Personen haben aufgrund des durch das Sj\u00f6gren-Syndrom verursachten Mundtrockenheit ein erh\u00f6htes Risiko, Hohlr\u00e4ume und Zahnverlust zu entwickeln. Regelm\u00e4\u00dfige Zahnpflege wird Personen mit dieser Erkrankung dringend empfohlen. Trinkwasser, Kaugummi und andere Methoden zur Stimulierung der Speichelproduktion k\u00f6nnen ebenfalls hilfreich sein. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Probenergebnisse<\/a><\/figure>\n\n

SJ\u00d6GRENS SYNDROM-ASSOZIIERTE VARIANTEN:<\/strong> Rs9271588, Rs3757387, Rs10553577, Rs485497, Rs2736345, Rs7119038, Rs6579837<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Sj\u00f6gren-Syndrom (Video)<\/a> <\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 5. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Varianten an mehreren Orten, die sowohl an angeborenen als auch an adaptiven Immunantworten beteiligt sind, sind mit dem Sj\u00f6gren-Syndrom assoziiert ZUSAMMENFASSUNG: Identifizierung von 7 Genomregionen, die mit dem Risiko des Sj\u00f6gren-Syndroms assoziiert sind. \u00dcBERBLICK: Das Sj\u00f6gren-Syndrom ist eine Autoimmunerkrankung, …<\/p>\n

Sj\u00f6gren-Syndrom (Lessard, 2013)<\/span> Read More 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