{"id":10145,"date":"2021-01-06T00:08:19","date_gmt":"2021-01-06T05:08:19","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-lungenkrebs-mckay-2017\/"},"modified":"2021-02-20T20:22:10","modified_gmt":"2021-02-21T01:22:10","slug":"genetik-lungenkrebs-mckay-2017","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-lungenkrebs-mckay-2017\/","title":{"rendered":"Lungenkrebs (McKay, 2017)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Eine gro\u00df angelegte Assoziationsanalyse identifiziert neue Anf\u00e4lligkeitsorte f\u00fcr Lungenkrebs und Heterogenit\u00e4t der genetischen Anf\u00e4lligkeit \u00fcber histologische Subtypen hinweg<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 4 neuen Genomregionen, die mit Lungenkrebs assoziiert sind. <\/p>\n\n

\u00dcBERBLICK:<\/strong> Lungenkrebs ist eine Erkrankung, bei der sich Zellen in der Lunge unkontrolliert teilen. Es ist die h\u00e4ufigste Ursache f\u00fcr krebsbedingte Todesf\u00e4lle in den Vereinigten Staaten. Es gibt zwei Haupttypen von Lungenkrebs: kleinzelligen Lungenkrebs und nicht-kleinzelligen Krebs, wobei letzterer 80 bis 85% aller Lungenkrebserkrankungen ausmacht. Obwohl Rauchen der h\u00e4ufigste Risikofaktor f\u00fcr die Erkrankung ist, wird angenommen, dass auch die Genetik eine Rolle spielt. Durch die Untersuchung von ~ 85.000 Genomen zielte diese Studie darauf ab, die genetischen Faktoren zu verstehen, die mit dem Risiko verbunden sind, an diesem Krebs zu erkranken. Die Forscher identifizierten 18 genetische Varianten im Zusammenhang mit der Erkrankung, von denen 10 neu sind. Von den neuen Regionen sind 4 insgesamt mit Lungenkrebs assoziiert. Einige dieser Regionen wurden zuvor mit Sucht und Rauchverhalten in Verbindung gebracht. Insgesamt erkl\u00e4ren die identifizierten genetischen Varianten 8,9% der Erblichkeit dieses Krebses. <\/p>\n\n

HAST DU GEWUSST?<\/strong> W\u00e4hrend Rauchen die h\u00e4ufigste Ursache f\u00fcr Lungenkrebs ist, tr\u00e4gt die Exposition gegen\u00fcber Radon, einem unsichtbaren radioaktiven Gas, ebenfalls zum Risiko bei. Radon wird aus dem normalen Zerfall der Elemente Uran, Thorium und Radium in Gesteinen und B\u00f6den freigesetzt. H\u00e4user, die auf B\u00f6den gebaut wurden, die reich an diesen Elementen sind, k\u00f6nnen h\u00f6here Radonwerte in der Luft aufweisen. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

STUDIENVERBUNDENE VARIANTEN:<\/strong> rs55781567, rs56113850, rs11571833, rs71658797, rs6920364, rs11780471, rs66759488<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Krebs in der Lunge (Video)<\/a> Lungenkrebsarten<\/a>Leben mit Lungenkrebs<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 12. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Eine gro\u00df angelegte Assoziationsanalyse identifiziert neue Anf\u00e4lligkeitsorte f\u00fcr Lungenkrebs und Heterogenit\u00e4t der genetischen Anf\u00e4lligkeit \u00fcber histologische Subtypen hinweg ZUSAMMENFASSUNG: Identifizierung von 4 neuen Genomregionen, die mit Lungenkrebs assoziiert sind. \u00dcBERBLICK: Lungenkrebs ist eine Erkrankung, bei der sich Zellen in …<\/p>\n

Lungenkrebs (McKay, 2017)<\/span> Read More 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