{"id":10150,"date":"2021-01-06T00:08:22","date_gmt":"2021-01-06T05:08:22","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-melanom-landi-2020\/"},"modified":"2021-02-20T20:18:58","modified_gmt":"2021-02-21T01:18:58","slug":"genetik-melanom-landi-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-melanom-landi-2020\/","title":{"rendered":"Melanom (Landi, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Genomweite Assoziations-Metaanalysen, die mehrere Risikoph\u00e4notypen kombinieren, liefern Einblicke in die genetische Architektur der Anf\u00e4lligkeit f\u00fcr Hautmelanome<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 54 Genomregionen, die mit dem Melanomrisiko assoziiert sind. <\/p>\n\n

\u00dcBERBLICK:<\/strong> Das Melanom ist die schwerste Art von Hautkrebs. In dieser Studie wurden ~ 36.000 Melanompatienten mit ~ 375.000 gesunden Personen europ\u00e4ischer Abstammung verglichen und 68 genetische Varianten in 54 verschiedenen Genomregionen identifiziert. Die Studie fand auch Zusammenh\u00e4nge zwischen Krebsrisiko und hellerer Hautfarbe sowie einer gr\u00f6\u00dferen Anzahl von Muttermalen am K\u00f6rper. Eine der Regionen, die sowohl mit Melanomen als auch mit Muttermalen assoziiert sind, befindet sich in der N\u00e4he des PARP1-Gens, eines DNA-Reparaturgens, das bei der Kontrolle des Melanom-verursachenden Gens MITF hilft. Eine andere Variante war mit der HLA-Region assoziiert, was auf eine Rolle der Immunit\u00e4t bei der Entwicklung von Hautkrebs hindeutet. Andere Gene waren an der Aufrechterhaltung der Telomere beteiligt. Die in dieser Studie entdeckten Genomregionen erkl\u00e4ren zusammen ~ 8,5% der Risikoheritabilit\u00e4t dieser Erkrankung. <\/p>\n\n

HAST DU GEWUSST?<\/strong> Es gibt viele Warnzeichen, um festzustellen, ob ein Fleck nur ein Maulwurf oder tats\u00e4chlich ein Melanom ist. Die einfachste \u00dcberpr\u00fcfung wird als „H\u00e4ssliches Entlein“ -Test bezeichnet. Wenn ein Maulwurf anders aussieht als die anderen Maulw\u00fcrfe auf Ihrem K\u00f6rper, wie das h\u00e4ssliche Entlein anders aussieht als seine Geschwister, lohnt es sich, es sich ansehen zu lassen! Melanome sind oft asymmetrisch, haben ungew\u00f6hnliche R\u00e4nder, unterschiedliche Farben, einen gro\u00dfen Durchmesser oder \u00e4ndern sich im Laufe der Zeit. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

STUDIENVERBUNDENE VARIANTEN:<\/strong> rs1805007, rs6059655, rs1126809, rs408825, rs16891982, rs7902587, rs871024, rs132941, rs1801516, rs117132860, rs4354713, rs1339759, rs6914598, rs10739220, rs2695237, rs13178866, rs32578, rs4731207, rs76798800, rs1800440, rs8444, rs4420522, rs149617956, rs143190905, rs72834823, rs10960710, rs12913832, rs1278768, rs117648907, rs3950296, rs10859996, rs78378222, rs12984831, rs113469387, rs4237963, rs7941496, rs5766565, rs2967383, rs1056927, rs6908626, rs6994183, rs12473635, rs12215602, rs79966207, rs7778378, rs670318, rs2369633, rs28986343, rs12539524, rs3780269, rs10931936, rs12290699, rs13263376, rs12523094<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>ABCDEs zur Erkennung von Melanomen (Video)<\/a>Woher das Melanom kommt, wie man es erkennt und wie man es verhindert (Video)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 12. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Genomweite Assoziations-Metaanalysen, die mehrere Risikoph\u00e4notypen kombinieren, liefern Einblicke in die genetische Architektur der Anf\u00e4lligkeit f\u00fcr Hautmelanome ZUSAMMENFASSUNG: Identifizierung von 54 Genomregionen, die mit dem Melanomrisiko assoziiert sind. \u00dcBERBLICK: Das Melanom ist die schwerste Art von Hautkrebs. In dieser Studie …<\/p>\n

Melanom (Landi, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6356,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10150","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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