{"id":10160,"date":"2021-01-06T00:08:29","date_gmt":"2021-01-06T05:08:29","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-lvedv-pirruccello-2020\/"},"modified":"2021-02-20T20:22:26","modified_gmt":"2021-02-21T01:22:26","slug":"genetik-von-lvedv-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-lvedv-pirruccello-2020\/","title":{"rendered":"Linksventrikul\u00e4res enddiastolisches Volumen (Pirruccello, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 14 genetischen Varianten, die mit dem linksventrikul\u00e4ren enddiastolischen Volumen (LVEDV) assoziiert sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Das menschliche Herz ist ein Muskel, der Blut durch den K\u00f6rper pumpt. Es besteht aus 4 Kammern: 2 Vorh\u00f6fe (links und rechts) und 2 Ventrikel (links und rechts). Mit Sauerstoff angereichertes Blut in der Lunge gelangt in das linke Atrium und flie\u00dft dann in den linken Ventrikel, von wo es in alle anderen K\u00f6rperteile gepumpt wird. Das linksventrikul\u00e4re enddiastolische Volumen (LVEDV) ist das Blutvolumen in einem entspannten linken Ventrikel, kurz bevor es sich zusammenzieht und Blut in den K\u00f6rper pumpt. Der durchschnittliche LVEDV betr\u00e4gt 120 ml f\u00fcr Frauen und 150 ml f\u00fcr M\u00e4nner und kann als Ma\u00df f\u00fcr die Herzgesundheit verwendet werden. Diese genomweite Assoziationsstudie untersuchte die Genome von 36.000 Personen europ\u00e4ischer Abstammung, um die genetischen Grundlagen von LVEDV besser zu verstehen. Die Studie identifizierte 14 mit LVEDV assoziierte Genomregionen, angepasst an die K\u00f6rperoberfl\u00e4che. Die Studie fand auch eine starke inverse Beziehung zwischen dem polygenen Score f\u00fcr gr\u00f6\u00dfere LVEDV und Hypothyreose. <\/p>\n\n

HAST DU GEWUSST?<\/strong> Im Durchschnitt pumpt das menschliche Herz t\u00e4glich ca. 7.600 Liter Blut durch den K\u00f6rper. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

LVEDV-ASSOZIIERTE VARIANTEN:<\/strong> Rs1873164, Rs9797817, Rs72967533, Rs72840788, Rs73028849, Rs1976402, Rs6458349, Rs9480737, Rs7502466, Rs12499670, Rs10850034<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Das Herz (Video)<\/a>Wie das Herz funktioniert<\/a>Enddiastolisches Volumen<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Linksventrikul\u00e4re Ejektionsfraktion (Pirruccello, 2020)<\/a>Linksventrikul\u00e4res end-systolisches Volumen (Pirruccello, 2020)<\/a>Schlagvolumen (Pirruccello, 2020)<\/a>Kardiomyopathie (Meder, 2014)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 19. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie ZUSAMMENFASSUNG: Identifizierung von 14 genetischen Varianten, die mit dem linksventrikul\u00e4ren enddiastolischen Volumen (LVEDV) assoziiert sind. \u00dcBERBLICK: Das menschliche Herz ist ein Muskel, der Blut …<\/p>\n

Linksventrikul\u00e4res enddiastolisches Volumen (Pirruccello, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6371,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10160","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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