{"id":10168,"date":"2021-01-06T00:08:35","date_gmt":"2021-01-06T05:08:35","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-des-schlaganfallvolumens-pirruccello-2020\/"},"modified":"2021-02-20T20:32:26","modified_gmt":"2021-02-21T01:32:26","slug":"genetik-des-schlaganfallvolumens-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-des-schlaganfallvolumens-pirruccello-2020\/","title":{"rendered":"Schlagvolumen (Pirruccello, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 12 genetischen Varianten, die mit dem Schlagvolumen des Herzens assoziiert sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Das menschliche Herz ist ein Muskel, der Blut durch den K\u00f6rper pumpt. Es besteht aus 4 Kammern: 2 Vorh\u00f6fe (links und rechts) und 2 Ventrikel (links und rechts). Mit Sauerstoff angereichertes Blut in der Lunge gelangt in das linke Atrium und flie\u00dft dann in den linken Ventrikel, von wo es in alle anderen K\u00f6rperteile gepumpt wird. Das Schlagvolumen (SV) ist ein Ma\u00df daf\u00fcr, wie viel Blut bei jedem Schlag aus dem linken Ventrikel gepumpt wird. Der durchschnittliche SV betr\u00e4gt 81 ml f\u00fcr Frauen und 95 ml f\u00fcr M\u00e4nner. Messungen des Schlagvolumens k\u00f6nnen anzeigen, ob das Herz genug Blut pumpt, um die Anforderungen des K\u00f6rpers zu erf\u00fcllen. Diese genomweite Assoziationsstudie mit \u00fcber 36.000 Personen europ\u00e4ischer Abstammung identifizierte 12 genetische Varianten, die mit SV korrelierten, einschlie\u00dflich Varianten in der N\u00e4he von Genen, die eine Rolle bei der Herzmuskelkontraktion (MYH6) und der Bildung von Blutgef\u00e4\u00dfen (VEGFA) spielen. Zusammen erkl\u00e4ren diese Varianten ~ 34% der Heritabilit\u00e4t des Schlagvolumens. Die Studie fand auch eine starke inverse Beziehung zwischen dem polygenen Score f\u00fcr gr\u00f6\u00dfere SV und Hypothyreose.<\/p>\n\n

HAST DU GEWUSST?<\/strong> W\u00e4hrend des Trainings ben\u00f6tigt der K\u00f6rper eine erh\u00f6hte Blutversorgung, um die Muskeln mit Sauerstoff zu versorgen. Im Laufe der Zeit kann Bewegung zu einer Steigerung der Herzleistung f\u00fchren und mehr Blut mit weniger Arbeit pumpen. Aerobe Aktivit\u00e4ten wie Laufen und Radfahren sind besonders effektiv bei der Erh\u00f6hung des Schlagvolumens. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

SV-assoziierte Varianten:<\/strong> Rs72967533, Rs11065979, Rs7573293, Rs11066188, Rs10400419, Rs888690, Rs422068, Rs111721712, Rs2891403, Rs2146324, Rs28391274, Rs143384<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Das Herz (Video)<\/a><\/a>Schlagvolumen und Herzfrequenz (Video)<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Linksventrikul\u00e4re Ejektionsfraktion (Pirruccello, 2020)<\/a> Linksventrikul\u00e4res enddiastolisches Volumen (Pirruccello, 2020)<\/a>Linksventrikul\u00e4res end-systolisches Volumen (Pirruccello, 2020)<\/a>Herzinsuffizienz (Shah, 2020)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 19. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie ZUSAMMENFASSUNG: Identifizierung von 12 genetischen Varianten, die mit dem Schlagvolumen des Herzens assoziiert sind. \u00dcBERBLICK: Das menschliche Herz ist ein Muskel, der Blut durch …<\/p>\n

Schlagvolumen (Pirruccello, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6381,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10168","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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