{"id":10173,"date":"2021-01-06T00:08:39","date_gmt":"2021-01-06T05:08:39","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-lvef-pirruccello-2020\/"},"modified":"2021-02-20T20:29:36","modified_gmt":"2021-02-21T01:29:36","slug":"genetik-von-lvef-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-lvef-pirruccello-2020\/","title":{"rendered":"Linksventrikul\u00e4re Ejektionsfraktion (Pirruccello, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 22 genetischen Varianten, die mit der linksventrikul\u00e4ren Ejektionsfraktion (LVEF) des Herzens assoziiert sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Das menschliche Herz ist ein Muskel, der Blut durch den K\u00f6rper pumpt. Es besteht aus 4 Kammern: 2 Vorh\u00f6fe (links und rechts) und 2 Ventrikel (links und rechts). Mit Sauerstoff angereichertes Blut in der Lunge gelangt in das linke Atrium und flie\u00dft dann in den linken Ventrikel, von wo es in alle anderen K\u00f6rperteile gepumpt wird. Wenn sich der linke Ventrikel zusammenzieht, wird nicht alles Blut ausgesto\u00dfen und ein Teil verbleibt im Ventrikel. Die linksventrikul\u00e4re Ejektionsfraktion (LVEF) wird berechnet, indem das Blutvolumen, das den linken Ventrikel verl\u00e4sst, wenn sich die Herzmuskeln zusammenziehen, durch das Blutvolumen dividiert wird, das im linken Ventrikel verbleibt. Eine normale linksventrikul\u00e4re Ejektionsfraktion (LVEF) liegt zwischen 55% und 70%. Um genetische Varianten zu identifizieren, die mit LVEF assoziiert sind, untersuchte diese genomweite Assoziationsstudie \u00fcber 36.000 Personen europ\u00e4ischer Abstammung. Die Studie identifizierte 22 genetische Varianten, einschlie\u00dflich Varianten in der N\u00e4he von Genen, die f\u00fcr die Flexibilit\u00e4t des Herzmuskels (TTN) und der mit dem Immunsystem verbundenen Gene verantwortlich sind. Zusammen erkl\u00e4ren diese Varianten ~ 31% der LVEF-Heritabilit\u00e4t. Die Studie fand auch heraus, dass ein hoher polygener Score f\u00fcr LVEF stark mit dem Risiko einer dilatativen Kardiomyopathie korreliert. Dieser Zustand beschreibt einen Herzmuskel, der zu d\u00fcnn gedehnt ist und nicht effizient pumpen kann.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Stress erh\u00f6ht die Herzfrequenz und den Blutdruck, was sich negativ auf die Gesundheit der Gesundheit auswirken kann. Das Ergreifen von Ma\u00dfnahmen zur Stresskontrolle durch Aktivit\u00e4ten wie Meditation, Bewegung und Therapie kann das Risiko f\u00fcr verschiedene Herzerkrankungen wirksam verringern. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

LVEF-ASSOZIIERTE VARIANTEN:<\/strong> rs72840788, rs1739837, rs2562845, rs11710541, rs3176326, rs3807309, rs12452367, rs2070458, rs56099248, rs8023658, rs35999985, rs5029142, rs10871753, rs10925197, rs4073554, rs36029352, rs113819537, rs9274626, rs2047273, rs189569984, rs721067, rs2503715<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Das Herz (Video)<\/a><\/a><\/a>Ejektionsfraktion<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Schlagvolumen (Pirruccello, 2020)<\/a>Linksventrikul\u00e4res enddiastolisches Volumen (Pirruccello, 2020)<\/a>Linksventrikul\u00e4res end-systolisches Volumen (Pirruccello, 2020)<\/a>Ruheherzfrequenz (Eppinga, 2016)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 19. Mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die Analyse der kardialen Magnetresonanztomographie bei 36.000 Personen liefert genetische Einblicke in die erweiterte Kardiomyopathie ZUSAMMENFASSUNG: Identifizierung von 22 genetischen Varianten, die mit der linksventrikul\u00e4ren Ejektionsfraktion (LVEF) des Herzens assoziiert sind. \u00dcBERBLICK: Das menschliche Herz ist ein Muskel, der …<\/p>\n

Linksventrikul\u00e4re Ejektionsfraktion (Pirruccello, 2020)<\/span> Read More 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Genetik der linksventrikul\u00e4ren Ejektionsfraktion (Pirruccello, 2020)<\/title>\n<meta name=\"description\" content=\"Laden Sie Ihre DNA-Daten hoch, untersuchen Sie genetische Varianten, die mit der linksventrikul\u00e4ren Ejektionsfraktion zusammenh\u00e4ngen (Pirruccello, 2020), und ermitteln Sie Ihren polygenen Score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/de\/genetik-von-lvef-pirruccello-2020\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Die Genetik der linksventrikul\u00e4ren Ejektionsfraktion (Pirruccello, 2020)\" \/>\n<meta property=\"og:description\" content=\"Laden Sie Ihre DNA-Daten hoch, untersuchen Sie genetische Varianten, die mit der linksventrikul\u00e4ren Ejektionsfraktion zusammenh\u00e4ngen (Pirruccello, 2020), und 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