{"id":10226,"date":"2021-01-06T00:11:15","date_gmt":"2021-01-06T05:11:15","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-luminal-a-brustkrebs-zhang-2020\/"},"modified":"2021-02-20T20:20:22","modified_gmt":"2021-02-21T01:20:22","slug":"genetik-luminal-a-brustkrebs-zhang-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-luminal-a-brustkrebs-zhang-2020\/","title":{"rendered":"Luminaler A-\u00e4hnlicher Brustkrebs (Zhang, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Genomweite Assoziationsstudie identifiziert 32 neuartige Orte f\u00fcr die Anf\u00e4lligkeit f\u00fcr Brustkrebs aus Gesamt- und subtypspezifischen Analysen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Entdeckung neuer genetischer Varianten im Zusammenhang mit luminalem A-\u00e4hnlichem Brustkrebs.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Bei Frauen ist Brustkrebs die zweith\u00e4ufigste Krebsart. Tats\u00e4chlich erkranken etwa 13% der Frauen in den USA im Laufe ihres Lebens an Brustkrebs. Brustkrebsarten k\u00f6nnen anhand von Tumormarkern klassifiziert werden, beispielsweise anhand der Rezeptoren auf der Oberfl\u00e4che von Krebszellen. Luminal A-like ist ein Subtyp von Brustkrebs mit der besten Prognose und macht 30-45% der Brustkrebsf\u00e4lle aus. Es ist gekennzeichnet durch Krebszellen, die aus den inneren oder luminalen Zellen stammen, die die Brustg\u00e4nge auskleiden. Dar\u00fcber hinaus ist dieser Brustkrebs-Subtyp durch ein krebsartiges Wachstum als Reaktion auf \u00fcbersch\u00fcssiges \u00d6strogen gekennzeichnet. Diese genomweite Assoziationsstudie untersuchte fast 266.000 Personen europ\u00e4ischer Abstammung, um genetische Varianten zu identifizieren, die mit verschiedenen Brustkrebsarten assoziiert sind, einschlie\u00dflich luminalem A-\u00e4hnlichem Brustkrebs. Insgesamt identifizierten die Forscher 330 Genomregionen, die mit Brustkrebsarten assoziiert sind, und verwendeten sie zur Berechnung der polygenen Scores. Bei luminalem A-\u00e4hnlichem Brustkrebs erkl\u00e4ren diese Varianten 54,3% der Erblichkeit.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Studien aus den 1940er Jahren legen nahe, dass Brustkrebs in der linken Brust h\u00e4ufiger auftritt als in der rechten. Bisher besteht jedoch kein Konsens dar\u00fcber, warum dies der Fall ist. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

LUMINALE A-ASSOZIIERTE VARIANTEN:<\/strong> rs9712235, rs4602255, rs1375631, rs188092014, rs13256025, rs13277568, rs4742903, rs11652463, rs495367, rs7924772, rs78378222, rs206435, rs6065254, rs17215231, rs612683, rs616488, rs7513707, rs12406858, rs637868, rs11249433, rs111458676, rs11205303, rs12091730, rs2992756, rs35383942, rs6686987, rs7514172, rs2785646, rs2576261, rs11117758, rs11118563, rs72755295, rs4233486, rs114282204, rs707475, rs17426269, rs2151842, rs78425380, rs6746250, rs17625845, rs10164550, rs10179592, rs17726078, rs1550622, rs2356656, rs6743383, rs10197246, rs4442975, rs11693806, rs3791977, rs4676356, rs6725517, rs12472404, rs4322799, rs6756513, rs1036759, rs58058861, rs9882792, rs552647, rs112476261, rs17838698, rs56387622, rs6762558, rs2886671, rs9825432, rs13066793, rs639355, rs62331150, rs56039025, rs28436676, rs62334414, rs13147907, rs10012017, rs17014016, rs17157372, Rs335160, Rs1428387, Rs10069690, Rs6860806, Rs6596100, Rs62329727, Rs1432679, Rs17611291, Rs10074269, Rs6864691, Rs4868701, Rs4866496, Rs1160 95464, rs187108781, rs4613718, rs10941679, rs17343002, rs889310, rs16886165, rs76250845, rs11949391, rs113778879, rs3010266, rs157557, rs332529, rs418053, rs2121348, rs6913578, rs60954078, rs851984, rs6904031, rs910416, rs3819405, rs9364472, rs6940159, rs12211970, rs9358466, rs34196306, rs111342015, rs73754909, rs71559437, rs7800548, rs12706954, rs68056147, rs62485509, rs7971, rs289997, rs74765302, rs13244925, rs17268829, rs4439053, rs111963714, rs62517052, rs12546444, rs13267382, rs62526620, rs35542655, rs12541094, rs7842619, rs12550713, rs10096351, rs1016578, rs7830152, rs66823261, rs1028016, rs310295, rs9693444, rs13365225, rs1511243, rs72658084, rs1533366, rs10816625, rs13294895, rs7848334, rs630965, rs1895062, rs3861871, rs17694493, rs4880038, rs10975870, rs665889, rs10120432, rs10885405, rs12250948, rs9421410, rs45631580, rs45631563, rs10796139, rs7072776, rs10764337, rs2384736, rs10995201, rs6479868, rs111833376, rs719338, rs4980029, rs7125780, rs610437, rs625145, rs7121616 939.702, rs11822830, rs10832963, rs4980386, rs4472923, rs7394715, rs10838267, rs77047825, rs12287832, rs10896047, rs35039974, rs661204, rs78540526, rs6597981, rs2454399, rs12422552, rs788458, rs7297051, rs2277339, rs17356907, rs56404467, rs11571833, rs9315973, rs12870942, rs2181965, rs4983544, rs34914085, rs2253012, rs2588809, rs11624333, rs941764, rs78440108, rs144767203, rs187010898, rs4774565, rs8042593, rs35874463, rs8035987, rs2290202, rs34872983, rs75753503, rs11076805, rs35668161, rs4784227, rs55872725, rs6499648, rs7184573, rs28539243, rs12709163, rs7500067, rs9931038, rs12449271, rs79461387, rs150537328, rs11296, rs17881320, rs149370081, rs2787486, rs745570, rs16976596, rs11665269, rs1111207, rs527616, rs8092192, rs72931898, rs9954058, rs9952980, rs117922601, rs56069439, rs10164323, rs56681946, rs4399645, rs1172821, rs1154723, rs6030585, Rs13039563, Rs16991615, Rs2822999, Rs2823130, Rs2403907, Rs4818836, Rs9798754, Rs17879961, Rs5997390, Rs34134147, Rs132289, Rs5750715, Rs96119 90, rs112855987, rs28512361<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Ursachen von Brustkrebs (Video)<\/a>Subtypen von Brustkrebs<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Luminaler B \/ HER2-negativer Brustkrebs (Zhang, 2020)<\/a>Luminaler B-\u00e4hnlicher Brustkrebs (Zhang, 2020)<\/a>HER2-angereicherter Brustkrebs (Zhang, 2020)<\/a>Dreifach negativer Brustkrebs (Zhang, 2020)<\/a>Brustkrebs (Michailidou, 2013)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 2. Juni 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Genomweite Assoziationsstudie identifiziert 32 neuartige Orte f\u00fcr die Anf\u00e4lligkeit f\u00fcr Brustkrebs aus Gesamt- und subtypspezifischen Analysen ZUSAMMENFASSUNG: Entdeckung neuer genetischer Varianten im Zusammenhang mit luminalem A-\u00e4hnlichem Brustkrebs. \u00dcBERBLICK: Bei Frauen ist Brustkrebs die zweith\u00e4ufigste Krebsart. Tats\u00e4chlich erkranken etwa 13% …<\/p>\n

Luminaler A-\u00e4hnlicher Brustkrebs (Zhang, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6461,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10226","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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B.S.","image":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/nebula.org\/blog\/de\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/32fb6e0dbc7e0bac908b0f23ea6ed5ec?s=96&d=mm&r=g","caption":"Garrett Dunlap, B.S."},"description":"Garrett Dunlap earned a B.S. in Biology from Case Western Reserve University with a minor in Political Science. He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/de\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts\/10226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/comments?post=10226"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts\/10226\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/media\/6461"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/media?parent=10226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/categories?post=10226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/tags?post=10226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}