{"id":10233,"date":"2021-01-06T00:11:47","date_gmt":"2021-01-06T05:11:47","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-dreifach-negativ-brustkrebs-zhang-2020\/"},"modified":"2021-02-20T20:28:19","modified_gmt":"2021-02-21T01:28:19","slug":"genetik-dreifach-negativ-brustkrebs-zhang-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-dreifach-negativ-brustkrebs-zhang-2020\/","title":{"rendered":"Dreifach negativer Brustkrebs (Zhang, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Genomweite Assoziationsstudie identifiziert 32 neuartige Orte f\u00fcr die Anf\u00e4lligkeit f\u00fcr Brustkrebs aus Gesamt- und subtypspezifischen Analysen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Entdeckung neuer genetischer Varianten im Zusammenhang mit dreifach negativem Brustkrebs.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Br\u00fcste sind komplexe Strukturen mit mehreren Zelltypen, die zu mehreren Krebsarten f\u00fchren k\u00f6nnen. Brustkrebs wird danach klassifiziert, welche Rezeptoren Krebszellen au\u00dfen haben. Diese Klassifizierung ist hilfreich f\u00fcr die Vorhersage von Ergebnissen und wirksamen Behandlungen. Dreifach negativer Brustkrebs ist jede Art von Brustkrebs, der weder den \u00d6strogenrezeptor, den Progesteronrezeptor noch den humanen epidermalen Wachstumsfaktor 2 (HER2) -Rezeptor aufweist. Dreifach negative Brustkrebserkrankungen sind immer noch ziemlich heterogen, wobei einige Subtypen aggressiver sind als andere. 15-20% aller Brustkrebsf\u00e4lle sind dreifach negative Brustkrebsf\u00e4lle. Diese Krebsarten weisen h\u00e4ufig auch Mutationen im BRCA1-Gen auf. Diese genomweite Assoziationsstudie untersuchte fast 266.000 Personen europ\u00e4ischer Abstammung, um genetische Varianten zu identifizieren, die mit verschiedenen Brustkrebsarten assoziiert sind, einschlie\u00dflich dreifach negativem Brustkrebs. Insgesamt identifizierten die Forscher 330 Genomregionen, die mit Brustkrebsarten assoziiert sind, und verwendeten sie zur Berechnung der polygenen Scores. Interessanterweise wurde festgestellt, dass einige Varianten das Risiko einiger Brustkrebsarten verringern und das Risiko anderer erh\u00f6hen. Beispielsweise sch\u00fctzt das G-Allel von rs78378222, einer mit dem Tumorsuppressorgen TP53 assoziierten Variante, vor dreifach negativem Brustkrebs, erh\u00f6ht jedoch das Risiko f\u00fcr luminalen B-\u00e4hnlichen Brustkrebs. Zusammen erkl\u00e4ren alle identifizierten Varianten ungef\u00e4hr 37,6% der Heritabilit\u00e4t f\u00fcr dreifach negativen Brustkrebs.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Da dreifach negative Brustkrebserkrankungen mit BRCA1-Mutationen assoziiert sind, legen einige Untersuchungen nahe, dass Frauen mit dreifach negativem Brustkrebs ebenfalls getestet werden sollten, um festzustellen, ob sie BRCA1-Mutationen tragen. BRCA1 \/ 2-Mutationen k\u00f6nnen das Risiko erh\u00f6hen, unabh\u00e4ngig vom ersten einen zweiten Brusttumor zu entwickeln. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"dreifach<\/a><\/figure>\n\n

TRIPLE NEGATIVE BRUSTKREBS-ASSOZIIERTE VARIANTEN:<\/strong> rs9712235, rs4602255, rs1375631, rs188092014, rs13256025, rs13277568, rs4742903, rs11652463, rs495367, rs7924772, rs78378222, rs206435, rs6065254, rs17215231, rs612683, rs616488, rs7513707, rs12406858, rs637868, rs11249433, rs111458676, rs11205303, rs2992756, rs35383942, rs6686987, rs7514172, rs2785646, rs2576261, rs11117758, rs11118563, rs72755295, rs4233486, rs114282204, rs707475, rs17426269, rs2151842, rs78425380, rs6746250, rs17625845, rs10164550, rs10179592, rs17726078, rs2356656, rs6743383, rs10197246, rs4442975, rs11693806, rs3791977, rs4676356, rs6725517, rs12472404, rs6756513, rs1036759, rs58058861, rs9882792, rs552647, rs112476261, rs17838698, rs56387622, rs6762558, rs2886671, rs9825432, rs13066793, rs639355, rs62331150, rs56039025, rs28436676, rs62334414, rs13147907, rs10012017, rs17014016, rs17157372, rs335160, rs1428387, rs10069690, rs6860806, rs6596100, rs62329727, rs1432679, rs17611291, rs10074269, rs6864691, rs4868701, rs4866496, rs116095464, rs187108781, rs4613718, rs1 0941679, rs17343002, rs889310, rs16886165, rs76250845, rs11949391, rs113778879, rs3010266, rs332529, rs418053, rs6913578, rs60954078, rs851984, rs6904031, rs910416, rs3819405, rs9364472, rs6940159, rs12211970, rs34196306, rs111342015, rs73754909, rs71559437, rs7800548, rs12706954, rs68056147, rs62485509, rs7971, rs289997, rs74765302, rs13244925, rs17268829, rs4439053, rs111963714, rs62517052, rs12546444, rs13267382, rs62526620, rs35542655, rs12541094, rs7842619, rs12550713, rs10096351, rs1016578, rs7830152, rs66823261, rs1028016, rs310295, rs9693444, rs13365225, rs1511243, rs72658084, rs1533366, rs7848334, rs630965, rs1895062, rs3861871, rs17694493, rs4880038, rs10975870, rs665889, rs10120432, rs10885405, rs12250948, rs9421410, rs45631580, rs45631563, rs10796139, rs7072776, rs10764337, rs2384736, rs10995201, rs6479868, rs111833376, rs719338, Rs4980029, Rs7125780, Rs625145, Rs7121616, Rs7939702, Rs11822830, Rs10832963, Rs4980386, Rs4472923, Rs10838267, Rs77047825, Rs12287832, Rs10896047 , Rs35039974, rs661204, rs78540526, rs6597981, rs2454399, rs12422552, rs788458, rs7297051, rs2277339, rs17356907, rs56404467, rs11571833, rs9315973, rs12870942, rs2181965, rs4983544, rs34914085, rs2253012, rs11624333, rs941764, rs78440108, rs144767203, rs187010898, rs4774565, rs8042593 , rs35874463, rs8035987, rs2290202, rs34872983, rs75753503, rs11076805, rs35668161, rs4784227, rs55872725, rs6499648, rs7184573, rs28539243, rs12709163, rs7500067, rs9931038, rs12449271, rs79461387, rs150537328, rs11296, rs17881320, rs149370081, rs2787486, rs745570, rs16976596, rs11665269 , rs1111207, rs527616, rs8092192, rs72931898, rs9954058, rs9952980, rs117922601, rs56069439, rs10164323, rs56681946, rs4399645, rs1172821, rs1154723, rs6030585, rs16991615, rs2822999, rs2823130, rs2403907, rs4818836, rs9798754, rs17879961, rs5997390, rs34134147, rs132289, rs5750715 , rs9611990, rs112855987, rs28512361<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Was ist dreifach negativer Brustkrebs? (Video)<\/a>Arten von Tumoren<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Luminaler A-\u00e4hnlicher Brustkrebs (Zhang, 2020)<\/a>Luminaler B \/ HER2-negativer Brustkrebs (Zhang, 2020)<\/a>Luminaler B-\u00e4hnlicher Brustkrebs (Zhang, 2020)<\/a>HER2-angereicherter Brustkrebs (Zhang, 2020)<\/a>Brustkrebs (Fachal, 2020)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 2. Juni 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Genomweite Assoziationsstudie identifiziert 32 neuartige Orte f\u00fcr die Anf\u00e4lligkeit f\u00fcr Brustkrebs aus Gesamt- und subtypspezifischen Analysen ZUSAMMENFASSUNG: Entdeckung neuer genetischer Varianten im Zusammenhang mit dreifach negativem Brustkrebs. \u00dcBERBLICK: Br\u00fcste sind komplexe Strukturen mit mehreren Zelltypen, die zu mehreren Krebsarten …<\/p>\n

Dreifach negativer Brustkrebs (Zhang, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6481,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10233","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/de\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts\/10233","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/comments?post=10233"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts\/10233\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/media\/6481"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/media?parent=10233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/categories?post=10233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/tags?post=10233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}