{"id":10250,"date":"2021-01-06T00:12:17","date_gmt":"2021-01-06T05:12:17","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-chronischen-wunde-mikrobiom-diversity-tipton-2020\/"},"modified":"2021-02-20T20:34:34","modified_gmt":"2021-02-21T01:34:34","slug":"genetik-der-chronischen-wunde-mikrobiom-diversity-tipton-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-chronischen-wunde-mikrobiom-diversity-tipton-2020\/","title":{"rendered":"Chronische Wundmikrobiomdiversit\u00e4t (Tipton, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Die Patientengenetik ist mit der Zusammensetzung und Heilung chronischer Wundmikrobiome verbunden<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 6 genetischen Varianten, die die Variation der Wundmikrobiomdiversit\u00e4t erkl\u00e4ren, ein kritischer Faktor im Wundheilungsprozess.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Normalerweise heilen Wunden innerhalb von Wochen oder Monaten ab und bilden h\u00e4ufig Narbengewebe \u00fcber der Verletzungsstelle. Chronische Wunden sind Wunden, die nach 3 oder mehr Wochen keine Anzeichen einer Heilung zeigen. Fr\u00fchere Studien haben gezeigt, dass die erfolgreiche Wundheilung von der Mikrobiomzusammensetzung der Wunde beeinflusst wird. Beispielsweise scheinen Wunden, die \u00fcberwiegend von nur wenigen Mikrobenarten besiedelt sind (= geringe Mikrobiomdiversit\u00e4t), langsamer zu heilen. In dieser Studie wurde versucht, genetische Marker zu finden, die mit der Vielfalt der Mikrobiome in chronischen Wunden assoziiert sind. Durch Untersuchung der genetischen Information von fast 80 Patienten identifizierte die Studie 6 genetische Varianten, die zur Berechnung eines polygenen Scores verwendet werden k\u00f6nnen, der 53% der Variation der Wundmikrobiomdiversit\u00e4t erkl\u00e4rt. Viele der Varianten treten in Genen auf, die mit Prozessen verbunden sind, die an der Wundheilung beteiligt sind, wie z. B. der Zelladh\u00e4sion.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Die Ern\u00e4hrung beeinflusst auch die Wundheilung. Zum Beispiel wird Vitamin C, das \u00fcblicherweise in Obst und Gem\u00fcse enthalten ist, ben\u00f6tigt, damit der K\u00f6rper Kollagen erzeugt. Kollagen ist ein Strukturprotein, das entscheidend daf\u00fcr ist, dass sich eine Wunde schlie\u00dft und sich Narbengewebe bildet. Zink und Protein in der Ern\u00e4hrung k\u00f6nnen auch dazu beitragen, eine schnelle und erfolgreiche Heilung zu f\u00f6rdern. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

MICROBIOME DIVERSITY-ASSOZIIERTE VARIANTEN:<\/strong> rs11984782, rs12307988, rs4758411, rs3846499, rs1436708, rs201276730 <\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Wie eine Wunde sich selbst heilt (Video)<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Atopische Dermatitis (Paternoster, 2015)<\/a>Psoriasis (Tsoi, 2015)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 3. Juli 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Die Patientengenetik ist mit der Zusammensetzung und Heilung chronischer Wundmikrobiome verbunden ZUSAMMENFASSUNG: Identifizierung von 6 genetischen Varianten, die die Variation der Wundmikrobiomdiversit\u00e4t erkl\u00e4ren, ein kritischer Faktor im Wundheilungsprozess. \u00dcBERBLICK: Normalerweise heilen Wunden innerhalb von Wochen oder Monaten ab und …<\/p>\n

Chronische Wundmikrobiomdiversit\u00e4t (Tipton, 2020)<\/span> Read More 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