{"id":10278,"date":"2021-01-06T00:21:47","date_gmt":"2021-01-06T05:21:47","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-langlebigkeit-timmer-2020\/"},"modified":"2021-02-20T20:21:14","modified_gmt":"2021-02-21T01:21:14","slug":"genetik-der-langlebigkeit-timmer-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-langlebigkeit-timmer-2020\/","title":{"rendered":"Langlebigkeit (Timmers, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Multivariater genomischer Scan impliziert neuartige Loci und H\u00e4m-Metabolismus beim Altern des Menschen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 10 genetischen Varianten im Zusammenhang mit Langlebigkeit.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Langlebigkeit ist ein Merkmal, das eine l\u00e4ngere Lebensdauer als die meisten Menschen hat. In dieser Studie wurde die Langlebigkeit speziell als l\u00e4nger als 90% der Menschen definiert. Obwohl Faktoren wie Ern\u00e4hrung und Zugang zur Gesundheitsversorgung die Lebenserwartung eines Menschen beeinflussen, spielt die Genetik auch eine Rolle f\u00fcr die Langlebigkeit. Diese genomweite Assoziationsstudie untersuchte \u00fcber 36.000 Personen europ\u00e4ischer Abstammung, um genetische Faktoren zu bestimmen, die mit der Langlebigkeit verbunden sind. Die Studie fand 10 genetische Varianten, die mit dem Merkmal, aber auch der Lebensdauer der Eltern und der Gesundheit zusammenh\u00e4ngen. Die Variante mit der st\u00e4rksten Assoziation (rs429358) befindet sich im APOE-Gen und ist mit der Alzheimer-Krankheit verbunden. Allein diese Variante bietet eine um ~ 1,7 h\u00f6here Wahrscheinlichkeit, l\u00e4nger als 90% der Menschen zu leben.<\/p>\n\n

HAST DU GEWUSST?<\/strong> \u201eBlaue Zonen\u201c sind Orte auf der ganzen Welt, an denen Menschen tendenziell viel l\u00e4nger als der Durchschnitt leben. Okinawa (Japan) und Ikaria (Griechenland) sind zwei solche Orte, an denen ein hoher Prozentsatz der Einwohner bis in die 90er Jahre lebt. Pflanzenreiche Di\u00e4ten und starke famili\u00e4re Verbindungen sind Merkmale, die in vielen \u201eblauen Zonen\u201c h\u00e4ufig vorkommen. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

LANGLEBIGKEITSVERBUNDENE VARIANTEN:<\/strong> Rs429358, Rs10455872, Rs7859727, Rs61905747, Rs6511720, Rs12830425, Rs1159806, Rs4783780, Rs2643826, Rs17499404<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong><\/a>Die Wissenschaft vom Altern (Video)<\/a>Wird die Langlebigkeit durch die Genetik bestimmt?<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Langlebigkeit (Deelen, 2019)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 28. Juli 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Multivariater genomischer Scan impliziert neuartige Loci und H\u00e4m-Metabolismus beim Altern des Menschen ZUSAMMENFASSUNG: Identifizierung von 10 genetischen Varianten im Zusammenhang mit Langlebigkeit. \u00dcBERBLICK: Langlebigkeit ist ein Merkmal, das eine l\u00e4ngere Lebensdauer als die meisten Menschen hat. In dieser Studie …<\/p>\n

Langlebigkeit (Timmers, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6666,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10278","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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