{"id":10283,"date":"2021-01-06T00:21:58","date_gmt":"2021-01-06T05:21:58","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-tsh-ebenen-zhou-2020\/"},"modified":"2021-02-20T20:22:00","modified_gmt":"2021-02-21T01:22:00","slug":"genetik-von-tsh-ebenen-zhou-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-tsh-ebenen-zhou-2020\/","title":{"rendered":"Schilddr\u00fcsen-stimulierender Hormonspiegel (Zhou, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> GWAS des Schilddr\u00fcsen-stimulierenden Hormons hebt pleiotrope Wirkungen und die inverse Assoziation mit Schilddr\u00fcsenkrebs hervor<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 28 neuen Regionen, die mit Schilddr\u00fcsen-stimulierenden Hormonspiegeln assoziiert sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Die Schilddr\u00fcse ist eine schmetterlingsf\u00f6rmige Dr\u00fcse, die sich vorne am Hals befindet. Es spielt eine entscheidende Rolle bei der Steuerung des Stoffwechsels des K\u00f6rpers, indem es reguliert, wie schnell wir Kalorien und viele andere Dinge verbrennen. Die Schilddr\u00fcse selbst wird von der Hypophyse gesteuert, die sich im Gehirn befindet, und setzt das Schilddr\u00fcsen-stimulierende Hormon (TSH) frei, das die Schilddr\u00fcse zum Handeln anspornt. TSH-Spiegel werden \u00fcblicherweise verwendet, um eine Vielzahl von Schilddr\u00fcsenerkrankungen zu diagnostizieren, einschlie\u00dflich Hypothyreose, Hyperthyreose und Schilddr\u00fcsenkrebs. Diese genomweite Assoziationsstudie untersuchte fast 120.000 Personen europ\u00e4ischer Abstammung, um besser zu verstehen, wie die Genetik die TSH-Spiegel beeinflussen kann. Die Studie identifizierte 74 Regionen im Genom, die mit TSH-Spiegeln zu assoziieren scheinen, von denen 28 neu entdeckt wurden. Eine der Regionen beherbergt das TSHR-Gen, das als Rezeptor f\u00fcr das Schilddr\u00fcsen-stimulierende Hormon fungiert. Die Studie fand auch heraus, dass eine genetische Veranlagung f\u00fcr h\u00f6here TSH-Spiegel mit einem verringerten Risiko f\u00fcr Schilddr\u00fcsenkrebs verbunden ist.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Frauen entwickeln zwischen 5-8x h\u00e4ufiger Schilddr\u00fcsenerkrankungen als M\u00e4nner. Im Durchschnitt leidet jede achte Frau im Laufe ihres Lebens an einer Schilddr\u00fcsenerkrankung. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"tsh<\/a><\/figure>\n\n

TSH LEVEL-ASSOZIIERTE VARIANTEN:<\/strong> rs1479567, rs2983511, rs11732089, rs1317983, rs2928167, rs13020935, rs58722186, rs12138950, rs9381266, rs334725, rs17477923, rs17020122, rs6575306, rs12284404, rs139352934, rs12027702, rs10748781, rs73234178, rs925488, rs4804416, rs1348005, rs121908872, rs116909374, rs10814915, rs61938844, rs1203949, rs8020969, rs118039499, rs1042678, rs59381142, rs310755, rs13100823, rs7873463, rs59148743, rs12893151, rs117764941, rs56009477, rs11156905, rs12942923, rs6724073, rs544873, rs10186921, rs9497965, rs2242602, rs179256, rs4445669, rs7318607, rs141751376, rs12590163, rs1265091, rs28133, rs34046483, rs7966590, rs9678281, rs4933466, rs11926459, rs1157994, rs10415188, rs11592436, rs700750, rs191633940, rs116956554, rs2993047, rs11583886, rs1045774, rs1045476, rs6721104, rs35587648, rs3104389, rs751171, rs6717283, 10.735.341, rs145153320, rs62174422, rs1801690, Rs2979181, Rs9298749, Rs3184504, Rs72978712, Rs12743883, Rs7083359, Rs12029562, Rs546738875, Rs6989821, Rs6085658, Rs77994712, Rs4571283, Rs s1373851, rs3731890, rs4719486, rs4393429, rs10421676, rs10878986, rs74888443, rs30233, rs9865818, rs72682433, rs5997969<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong><\/a>Wie deine Schilddr\u00fcse funktioniert<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Autoimmunerkrankung der Schilddr\u00fcse (Saevarsdottir, 2020)<\/a>Schilddr\u00fcsenkrebs (Liyanarachchi, 2020)<\/a>Schilddr\u00fcsenkrebs (Gudmundsson, 2017)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 18. August 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: GWAS des Schilddr\u00fcsen-stimulierenden Hormons hebt pleiotrope Wirkungen und die inverse Assoziation mit Schilddr\u00fcsenkrebs hervor ZUSAMMENFASSUNG: Identifizierung von 28 neuen Regionen, die mit Schilddr\u00fcsen-stimulierenden Hormonspiegeln assoziiert sind. \u00dcBERBLICK: Die Schilddr\u00fcse ist eine schmetterlingsf\u00f6rmige Dr\u00fcse, die sich vorne am Hals befindet. …<\/p>\n

Schilddr\u00fcsen-stimulierender Hormonspiegel (Zhou, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6791,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10283","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie Genetik des Schilddr\u00fcsen-stimulierenden Hormonspiegels (Zhou, 2020)<\/title>\n<meta name=\"description\" content=\"Laden Sie Ihre DNA-Daten hoch, untersuchen Sie genetische Varianten, die mit Schilddr\u00fcsen-stimulierenden Hormonspiegeln zusammenh\u00e4ngen (Zhou, 2020), und entdecken Sie Ihren polygenen Score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/de\/genetik-von-tsh-ebenen-zhou-2020\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Die Genetik des Schilddr\u00fcsen-stimulierenden Hormonspiegels (Zhou, 2020)\" \/>\n<meta property=\"og:description\" content=\"Laden Sie Ihre DNA-Daten hoch, untersuchen Sie genetische Varianten, die mit Schilddr\u00fcsen-stimulierenden Hormonspiegeln zusammenh\u00e4ngen (Zhou, 2020), und entdecken Sie Ihren 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