{"id":10324,"date":"2021-01-06T00:25:54","date_gmt":"2021-01-06T05:25:54","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-myeloproliferativen-neoplasmen-bao-2020\/"},"modified":"2021-02-20T20:26:48","modified_gmt":"2021-02-21T01:26:48","slug":"genetik-von-myeloproliferativen-neoplasmen-bao-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-myeloproliferativen-neoplasmen-bao-2020\/","title":{"rendered":"Myeloproliferative Neoplasien (Bao, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Das Risiko eines vererbten myeloproliferativen Neoplasmas betrifft h\u00e4matopoetische Stammzellen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Entdeckung von 17 Regionen des Genoms, die mit einem Risiko f\u00fcr myeloproliferative Neoplasien, einer Art von Blutkrebs, verbunden sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Blutk\u00f6rperchen, einschlie\u00dflich roter Blutk\u00f6rperchen, wei\u00dfer Blutk\u00f6rperchen und Blutpl\u00e4ttchen, werden im Knochenmark produziert, einem schwammigen Gewebe innerhalb der Knochen. Myeloproliferative Neoplasien sind eine Art von Blutkrebs, der auftritt, wenn das Knochenmark Blutstammzellen \u00fcberproduziert. H\u00e4ufige Symptome der Erkrankung sind Schw\u00e4chegef\u00fchle, M\u00fcdigkeit, Kopfschmerzen und Fieber. Um Faktoren zu identifizieren, die zu einer genetischen Veranlagung f\u00fcr diese Krankheit beitragen, untersuchte diese Studie die Genome von \u00fcber 1,15 Millionen Personen europ\u00e4ischer Abstammung. Die Forscher identifizierten 17 Varianten, die mit einem erh\u00f6hten Risiko f\u00fcr die Erkrankung verbunden sind, darunter 7, \u00fcber die zuvor nicht berichtet wurde. Insgesamt k\u00f6nnen diese Varianten \u00fcber 18% des gesamten genetischen Risikos f\u00fcr die Entwicklung myeloproliferativer Neoplasien erkl\u00e4ren.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Es gibt mehrere Arten von myeloproliferativen Neoplasmen, die von den betroffenen Zellen kategorisiert werden. Beispielsweise ist die Polyzyth\u00e4mie vera durch eine \u00dcberproduktion roter Blutk\u00f6rperchen gekennzeichnet, w\u00e4hrend eine chronische myeloische Leuk\u00e4mie durch eine \u00dcberproduktion wei\u00dfer Blutk\u00f6rperchen verursacht wird. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> .<\/p>\n\n

\"myeloproliferative<\/a><\/figure>\n\n

<\/p>\n\n

STUDIENVERBUNDENE VARIANTEN:<\/strong> rs1327494, rs7705526, rs2853677, rs62329718, rs62471615, rs7310615, rs116466979, rs1633768, rs1800057, rs74676712, rs9847631, rs8002412, rs7847631, rs8002412, rs7747901<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Myeloproliferative Neoplasien<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Blutkrebs (Lin, 2019)<\/a>Akute lymphoblastische Leuk\u00e4mie (Vijayakrishnan, 2019)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 24. Oktober 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Das Risiko eines vererbten myeloproliferativen Neoplasmas betrifft h\u00e4matopoetische Stammzellen ZUSAMMENFASSUNG: Entdeckung von 17 Regionen des Genoms, die mit einem Risiko f\u00fcr myeloproliferative Neoplasien, einer Art von Blutkrebs, verbunden sind. \u00dcBERBLICK: Blutk\u00f6rperchen, einschlie\u00dflich roter Blutk\u00f6rperchen, wei\u00dfer Blutk\u00f6rperchen und Blutpl\u00e4ttchen, werden …<\/p>\n

Myeloproliferative Neoplasien (Bao, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6951,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10324","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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