{"id":10346,"date":"2021-01-06T00:26:35","date_gmt":"2021-01-06T05:26:35","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-des-knie-schmerz-meng-2019\/"},"modified":"2021-02-20T20:55:03","modified_gmt":"2021-02-21T01:55:03","slug":"genetik-des-knie-schmerz-meng-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-des-knie-schmerz-meng-2019\/","title":{"rendered":"Knieschmerzen (Meng, 2019)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Genomweite Assoziationsstudie zu Knieschmerzen identifiziert Assoziationen mit GDF5 und COL27A1 in der britischen Biobank<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 2 genetischen Varianten, die mit Knieschmerzen assoziiert sind.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Ihr Knie ist das gr\u00f6\u00dfte Gelenk im K\u00f6rper und es ist entscheidend f\u00fcr die Unterst\u00fctzung Ihres K\u00f6rpergewichts, wenn Sie gehen, joggen, aufrecht stehen und sich b\u00fccken. Jahrelanger Verschlei\u00df kann Ihre Knie belasten und Knieschmerzen verursachen. Tats\u00e4chlich leiden ~ 50% der Personen \u00fcber 50 an dieser Krankheit. Um die genetischen Grundlagen von Knieschmerzen besser zu verstehen, f\u00fchrten die Forscher eine genomweite Assoziationsstudie durch, in der die Genome von \u00fcber 170.000 Personen europ\u00e4ischer Abstammung untersucht wurden. Die Studie identifizierte 2 genetische Varianten, die mit Knieschmerzen assoziiert sind. Von diesen genetischen Varianten befindet sich eine in der N\u00e4he eines Gens, das zuvor an Arthrose beteiligt war. Arthrose ist die Abnutzung des flexiblen Schutzgewebes, das als Knorpel an den Knochenenden bekannt ist. Die andere Variante befindet sich in der N\u00e4he eines Gens, das f\u00fcr die Umwandlung von Knorpel in Knochen wichtig ist.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Das menschliche Skelett besteht aus \u00fcber 200 Knochen! Die Fabella ist ein winziger Knochen hinter dem Knie, der w\u00e4hrend der Evolution des Menschen gr\u00f6\u00dftenteils verschwunden ist, aber bei einigen Individuen immer noch vorkommt. Es tritt h\u00e4ufiger bei Personen auf, die unter Knieschmerzen leiden, es ist jedoch unklar, ob das Vorhandensein der Fabella die Erkrankung verursacht. [<\/a> QUELLE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

<\/p>\n\n

KNEE PAIN-ASSOCIATED VARIANTS:<\/strong> rs143384, rs6120946, rs2808772, rs919642<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Anatomie des Knies (Video)<\/a>Werden zerbrechliche Knie vererbt?<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 10. Januar 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Genomweite Assoziationsstudie zu Knieschmerzen identifiziert Assoziationen mit GDF5 und COL27A1 in der britischen Biobank ZUSAMMENFASSUNG: Identifizierung von 2 genetischen Varianten, die mit Knieschmerzen assoziiert sind. \u00dcBERBLICK: Ihr Knie ist das gr\u00f6\u00dfte Gelenk im K\u00f6rper und es ist entscheidend f\u00fcr …<\/p>\n

Knieschmerzen (Meng, 2019)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5111,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10346","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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