{"id":10360,"date":"2021-01-06T00:26:49","date_gmt":"2021-01-06T05:26:49","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-brustkrebs-fachal-2020\/"},"modified":"2021-02-20T20:49:18","modified_gmt":"2021-02-21T01:49:18","slug":"genetik-von-brustkrebs-fachal-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-brustkrebs-fachal-2020\/","title":{"rendered":"Brustkrebs (Fachal, 2020)"},"content":{"rendered":"\n<p><strong>STUDIENTITEL:<\/strong><a href=\"https:\/\/www.nature.com\/articles\/s41588-019-0537-1\"> Die Feinkartierung von 150 Brustkrebs-Risikoregionen identifiziert 191 wahrscheinliche Zielgene.<\/a><\/p>\n\n<p><strong>ZUSAMMENFASSUNG:<\/strong> Identifizierung von 206 genetischen Varianten, die mit einem Brustkrebsrisiko verbunden sind.<\/p>\n\n<p><strong>\u00dcBERBLICK:<\/strong> Brustkrebs ist derzeit die zweith\u00e4ufigste Krebsart bei Frauen (nach Hautkrebs) und betrifft fast 1 von 8 im Laufe ihres Lebens. Fast 10% aller F\u00e4lle von Brustkrebs gelten als erblich. Diese Studie untersuchte genetische Daten von \u00fcber 215.000 Frauen europ\u00e4ischer Abstammung, um genetische Regionen zu identifizieren, die mit einem erh\u00f6hten Risiko f\u00fcr die Entwicklung von Brustkrebs verbunden sind. Die Analyse ergab 206 Varianten in 129 Genomregionen, die stark mit dem Brustkrebsrisiko assoziiert sind. Zusammen erkl\u00e4ren diese genetischen Varianten \u00fcber 20% des erblichen Krebsrisikos. Viele der entdeckten Varianten befinden sich in der N\u00e4he von Genen, die mit dem Immunsystem verwandt sind, was auf seine Bedeutung f\u00fcr den Schutz vor Krebs hinweist.<br\/><\/p>\n\n<p><strong>HAST DU GEWUSST?<\/strong> Untersuchungen legen nahe, dass eine langfristige Exposition gegen\u00fcber einigen Kunststoffen das Risiko f\u00fcr die Entwicklung von Brustkrebs erh\u00f6hen kann. Insbesondere Kunststoffe, die Bisphenol A (BPA) enthalten. Es wird angenommen, dass es das Hormonsystem st\u00f6rt, indem es das weibliche Sexualhormon \u00d6strogen nachahmt. Achten Sie auf das Etikett \u201eBPA-frei\u201c auf Kunststoffen und wechseln Sie zu einer wiederverwendbaren Wasserflasche aus Metall oder Glas. [<a href=\"https:\/\/www.breastcancer.org\/risk\/factors\/plastic\">QUELLE<\/a> ]]<\/p>\n\n<p><strong>BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die<a href=\"https:\/\/nebula.org\/blog\/de\/nebula-library-unlocking-gen-forschung\/\"> Nebula Research Library<\/a> . <\/p>\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><img decoding=\"async\" width=\"1024\" height=\"375\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-1024x375.png\" alt=\"Ergebnisse der Brustkrebsprobe\" class=\"wp-image-1128\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-1024x375.png 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-300x110.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-768x281.png 768w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3-1536x562.png 1536w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/image-3.png 924w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n<p><\/p>\n\n<p><strong>ANALYSIERTE VARIANTEN: <\/strong>rs4784227, rs10941679, rs4442975, rs11249433, rs186430430, rs659713, rs62355902, rs7297051, rs10995201, rs1353783, rs10069690, rs138522813, rs35378451, rs2403907, rs754416, rs17356907, rs244321, rs1352944, rs60037937, rs620315, rs2307561, rs45631563, rs199660865, rs55872725, rs4951401, rs78540526, rs66987842, rs8105994, rs7098100, rs851984, rs31864, rs34133739, rs12173562, rs7664956, rs5838651, rs657244, rs7465364, rs9938021, rs657686, rs12881240, rs9421409, rs56344893, rs2736107, rs10816625, rs11373454, rs2478777, rs6787391, rs2992756, rs35263707, rs13294895, rs4849879, rs10762851, rs4286946, rs5995543, rs7813150, rs2003526, rs11571833, rs9925952, rs13153426, rs143384623, rs71403627, rs62334412, rs4950774, rs2016394, rs984113, rs3769821, rs56387622, rs35422, rs78955132, rs405447, rs12706954, rs2059891, rs12250948, rs7625643, rs12048493, Rs1964292, Rs28539243, Rs527616, Rs56722914, Rs9952980, Rs12594752, Rs7796917, Rs1057941, Rs11341843, Rs190443933, Rs72755295, Rs548082010, Rs1882155 rs13294352, rs848088, rs7017073, rs12039667, rs4076654, rs35409891, rs138026227, rs35961416, rs148509105, rs17879961, rs4871411, rs74174203, rs17625845, rs419018, rs150957507, rs6854739, rs571173399, rs17617028, rs745382, rs78105464, rs7763102, rs1879854, rs112497245, rs10034903, rs200835870, rs71973726, rs61862474, rs78440108, rs67397200, rs6973318, rs62485509, rs58847541, rs506186, rs10096351, rs117618124, rs2328531, rs5997389, rs6569648, rs7541276, rs12422552, rs2822999, rs11448973, rs11102701, rs373575834, rs34810249, rs10641009, rs671888, rs1600346, rs10184522, rs11117754, rs7785971, rs537267133, rs199661266, rs12652713, rs2587505, rs13015648, rs2384061, rs12970390, rs2012709, rs7589172, rs1469713, rs3819405, rs35383942, rs7971, rs7081544, rs11382527, rs2981578, rs79309050, rs13020413, rs4800749, rs17303163, rs184486140, rs9619765, rs8137282, rs11583393, Rs13267382, Rs4066743, Rs7529522, Rs6500580, Rs62070949, Rs555060306, Rs150804576, Rs17513613, Rs59867004, Rs201000337, Rs80635 64, rs13066793, rs200366104, rs78269692, rs16991615, rs11704298, rs368848598, rs11067765, rs3846498, rs17432750, rs7730210, rs9573140, rs180952292, rs149934734, rs2363956, rs35054928, rs79388591, rs9918437, rs144101714, rs7899765, rs66496128, rs17467658, rs4587, rs184070480, rs10472097, rs72764096, rs7740686, rs7763637<\/p>\n\n<p><strong>ZUS\u00c4TZLICHE RESSOURCEN:<\/strong><br\/><a href=\"https:\/\/www.cancer.org\/cancer\/breast-cancer\/about\/what-is-breast-cancer.html\">Brustkrebs<\/a><\/p>\n\n<p><strong>W\u00d6CHENTLICHES UPDATE:<\/strong> 17. Januar 2020<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STUDIENTITEL: Die Feinkartierung von 150 Brustkrebs-Risikoregionen identifiziert 191 wahrscheinliche Zielgene. ZUSAMMENFASSUNG: Identifizierung von 206 genetischen Varianten, die mit einem Brustkrebsrisiko verbunden sind. \u00dcBERBLICK: Brustkrebs ist derzeit die zweith\u00e4ufigste Krebsart bei Frauen (nach Hautkrebs) und betrifft fast 1 von 8 im &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/de\/genetik-von-brustkrebs-fachal-2020\/\"> <span class=\"screen-reader-text\">Brustkrebs (Fachal, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5126,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10360","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.13 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Die Genetik der Anf\u00e4lligkeit f\u00fcr Brustkrebs (Fachal, 2020)<\/title>\n<meta name=\"description\" content=\"Laden Sie Ihre DNA-Daten hoch, untersuchen Sie genetische Varianten im Zusammenhang mit der Anf\u00e4lligkeit f\u00fcr Brustkrebs (Fachal, 2020) und ermitteln Sie Ihren polygenen Score.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/de\/genetik-von-brustkrebs-fachal-2020\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Die Genetik der Anf\u00e4lligkeit f\u00fcr Brustkrebs (Fachal, 2020)\" \/>\n<meta property=\"og:description\" content=\"Laden Sie Ihre DNA-Daten hoch, untersuchen Sie genetische Varianten im Zusammenhang mit der Anf\u00e4lligkeit f\u00fcr Brustkrebs (Fachal, 2020) und ermitteln Sie Ihren polygenen Score.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/nebula.org\/blog\/de\/genetik-von-brustkrebs-fachal-2020\/\" \/>\n<meta property=\"og:site_name\" content=\"Nebula Genomics Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/facebook.com\/nebulagenomics\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-06T05:26:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-02-21T01:49:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/sarah-cervantes-BOBMNKVry0Q-unsplash-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"924\" \/>\n\t<meta property=\"og:image:height\" content=\"616\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Garrett Dunlap, B.S.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" 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He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/de\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts\/10360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/comments?post=10360"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/posts\/10360\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/media\/5126"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/media?parent=10360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/categories?post=10360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/de\/wp-json\/wp\/v2\/tags?post=10360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}