{"id":10375,"date":"2021-01-06T00:27:05","date_gmt":"2021-01-06T05:27:05","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-akne-navarini-2019\/"},"modified":"2021-02-20T20:33:58","modified_gmt":"2021-02-21T01:33:58","slug":"genetik-der-akne-navarini-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-akne-navarini-2019\/","title":{"rendered":"Akne (Navarini, 2019)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Genomweite Assoziationsstudie identifiziert drei neue Anf\u00e4lligkeitsorte f\u00fcr schwere Akne vulgaris<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Eine Dysregulation des TGF\u03b2-Signalwegs kann die Anf\u00e4lligkeit f\u00fcr Akne erh\u00f6hen.<\/p>\n\n

BESCHREIBUNG:<\/strong> Akne ist eine entz\u00fcndliche Erkrankung der Haut, bei der Haarfollikel mit \u00d6l und abgestorbenen Hautzellen verstopft werden. Es ist zu etwa 80% vererbbar. Diese genomweite Assoziationsstudie umfasste 1.893 Patienten mit dieser Hauterkrankung und 5.132 gesunde Personen aus dem Vereinigten K\u00f6nigreich. Die Studie identifizierte 3 genetische Varianten, die mit den Genen OVOL1, FST und TGF\u03b22 verkn\u00fcpft sind, die alle mit dem Signalweg der TGF\u03b2-Zellen assoziiert sind. Der TGF\u03b2-Signalweg (Transforming Growth Factor Beta) ist an zahlreichen Prozessen sowohl bei Erwachsenen als auch bei Embryonen beteiligt. Einige dieser Prozesse umfassen Zellwachstum, Aufrechterhaltung normaler Zellbedingungen und Apoptose (programmierter Zelltod).<\/p>\n\n

HAST DU GEWUSST?<\/strong> Zus\u00e4tzlich zu Medikamenten oder Hautpflegeprodukten k\u00f6nnen Sie diesen Hautzustand verhindern, indem Sie Ihr Gesicht zweimal t\u00e4glich waschen, Ihr Haar sauber halten, keine Pickel knallen oder pfl\u00fccken und Sonnenschutzmittel tragen, wenn Sie nach drau\u00dfen gehen. [ QUELLE<\/a> ]]<\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> .<\/p>\n\n

\"Akne-Beispielbericht.\"<\/a><\/figure>\n\n

<\/p>\n\n

ACNE-ASSOZIIERTE VARIANTEN:<\/strong> rs478304, rs38055, rs1159268<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>TGF\u03b2-Signalweg<\/a>Apoptose<\/a>\u00dcberblick \u00fcber Akne<\/a>Akne in Bewegung<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 23. Juli 2019<\/p>\n\n

Schauen Sie sich auch unsere an \u00dcberpr\u00fcfung der Kurologie<\/a> !<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Genomweite Assoziationsstudie identifiziert drei neue Anf\u00e4lligkeitsorte f\u00fcr schwere Akne vulgaris ZUSAMMENFASSUNG: Eine Dysregulation des TGF\u03b2-Signalwegs kann die Anf\u00e4lligkeit f\u00fcr Akne erh\u00f6hen. BESCHREIBUNG: Akne ist eine entz\u00fcndliche Erkrankung der Haut, bei der Haarfollikel mit \u00d6l und abgestorbenen Hautzellen verstopft werden. …<\/p>\n

Akne (Navarini, 2019)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5106,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10375","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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