{"id":10379,"date":"2021-01-06T00:27:10","date_gmt":"2021-01-06T05:27:10","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-alzheimer-krankheit-wang-2019\/"},"modified":"2021-02-20T20:49:36","modified_gmt":"2021-02-21T01:49:36","slug":"genetik-der-alzheimer-krankheit-wang-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-alzheimer-krankheit-wang-2019\/","title":{"rendered":"Alzheimer-Krankheit (Wang, 2019)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Genomweite Assoziationsstudie identifiziert CD1A, das mit der Anstiegsrate des Plasma-Neurofilament-Lichts bei nicht dementen \u00c4ltesten assoziiert ist<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Genetische Varianten im CD1A-Gen sind mit einem Anstieg der NFL-Proteine im Blut und einem h\u00f6heren Alzheimer-Risiko verbunden.<\/p>\n\n

BESCHREIBUNG:<\/strong> Die Alzheimer-Krankheit f\u00fchrt zu einem allm\u00e4hlichen R\u00fcckgang des Ged\u00e4chtnisses und der Denkf\u00e4higkeit, indem die Nervenzellen im Gehirn gesch\u00e4digt werden. Neurofilament Light Proteins (NFL) werden h\u00e4ufig verwendet, um das Vorhandensein oder Fortschreiten von Alzheimer und anderen neurodegenerativen Erkrankungen zu testen. Der genetische Beitrag, der zu erh\u00f6hten NFL-Spiegeln im Blut f\u00fchrt, ist nicht gut verstanden. Diese Studie untersuchte 545 nicht-hispanische wei\u00dfe Teilnehmer, um genetische Varianten zu finden, die mit erh\u00f6hten NFL-Spiegeln im Blut und damit mit einem erh\u00f6hten Alzheimer-Risiko zusammenh\u00e4ngen. Die identifizierten genetischen Varianten befanden sich im CD1A-Gen – einem Gen, das im Immunsystem eine Rolle spielt.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Die Kontrolle von Bluthochdruck oder hohem Cholesterinspiegel kann das Alzheimer-Risiko verringern. Dar\u00fcber hinaus kann k\u00f6rperliche und soziale Aktivit\u00e4t dazu beitragen, diese Krankheit zu verhindern. [ QUELLE<\/a> ]]<\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> .<\/p>\n\n

\"Beispielbericht<\/a><\/figure>\n\n

<\/p>\n\n

ALZHEIMER-ASSOZIIERTE VARIANTEN:<\/strong> rs16840041<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong> Neurofilament Light Polypeptid<\/a>\u00dcberblick \u00fcber die Alzheimer-Krankheit<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 26. Juli 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Genomweite Assoziationsstudie identifiziert CD1A, das mit der Anstiegsrate des Plasma-Neurofilament-Lichts bei nicht dementen \u00c4ltesten assoziiert ist ZUSAMMENFASSUNG: Genetische Varianten im CD1A-Gen sind mit einem Anstieg der NFL-Proteine im Blut und einem h\u00f6heren Alzheimer-Risiko verbunden. BESCHREIBUNG: Die Alzheimer-Krankheit f\u00fchrt zu …<\/p>\n

Alzheimer-Krankheit (Wang, 2019)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5131,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10379","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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