{"id":10416,"date":"2021-01-06T00:27:49","date_gmt":"2021-01-06T05:27:49","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-arthrose-arcogen-konsortium-2012\/"},"modified":"2021-02-20T20:41:45","modified_gmt":"2021-02-21T01:41:45","slug":"genetik-arthrose-arcogen-konsortium-2012","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-arthrose-arcogen-konsortium-2012\/","title":{"rendered":"Arthrose (arcOGEN Consortium, 2012)"},"content":{"rendered":"\n<p><strong>STUDIENTITEL:<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3443899\/\"> Identifizierung neuer Anf\u00e4lligkeitsorte f\u00fcr Arthrose (arcOGEN): eine genomweite Assoziationsstudie<\/a><\/p>\n\n<p><strong>ZUSAMMENFASSUNG:<\/strong> Eine genetische Variante des GNL3-Gens kann das Risiko f\u00fcr Arthrose erh\u00f6hen.<br\/><\/p>\n\n<p><strong>BESCHREIBUNG:<\/strong> Arthrose ist die weltweit h\u00e4ufigste Form von Arthritis. Es wird auch als &#8222;Verschlei\u00df&#8220; Arthritis bezeichnet und tritt auf, wenn der Knorpel zwischen den Gelenken zusammenbricht, was zu Schmerzen, Steifheit und Schwellung f\u00fchrt. Es ist bekannt, dass dieser Zustand eine vererbbare Komponente hat, die zum Risiko beitr\u00e4gt, aber die genetischen Faktoren sind nicht genau definiert. Diese Studie untersuchte 18.419 Personen europ\u00e4ischer Abstammung und identifizierte eine Variante des GNL3-Gens, die mit der Erkrankung assoziiert ist. Das GNL3-Protein, auch als Nucleostemin bekannt, ist f\u00fcr die Regulierung des Zellzyklus in Stammzellen essentiell. Obwohl die genaue Beziehung zwischen Nucleostemin und Knorpelzellen unbekannt ist, haben Studien gezeigt, dass bei Osteoarthritis-Patienten erh\u00f6hte Nucleostemin-Proteinspiegel gefunden werden. Dies legt nahe, dass das GNL3-Gen f\u00fcr das Fortschreiten dieses Zustands wichtig sein k\u00f6nnte.<br\/><\/p>\n\n<p><strong>HAST DU GEWUSST?<\/strong> \u00dcbungen mit geringen Auswirkungen, einschlie\u00dflich Krafttraining und Dehnen mit Aerobic-\u00dcbungen, k\u00f6nnen die Gesundheit der Gelenke verbessern und zur Vorbeugung von Arthrose beitragen. Die Aufrechterhaltung eines angemessenen Gewichts und das Ausruhen von verletzten oder geschwollenen Gelenken kann auch das Risiko f\u00fcr Arthrose verringern. [<a href=\"https:\/\/www.healthline.com\/health\/osteoarthritis-prevention#lifestyle-changes\"> QUELLE<\/a> ]]<\/p>\n\n<p><strong>BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die<a href=\"https:\/\/nebula.org\/blog\/de\/nebula-library-unlocking-gen-forschung\/\"> Nebula Research Library<\/a> .<\/p>\n\n<figure class=\"wp-block-image size-large\"><a href=\"https:\/\/nebula.org\/free-dna-upload-analysis\/\"><img decoding=\"async\" width=\"1024\" height=\"375\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics-1024x375.png\" alt=\"Ergebnisse der Arthrose-Probe.\" class=\"wp-image-1066\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics-1024x375.png 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics-300x110.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics-768x281.png 768w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics-1536x562.png 1536w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics.png 924w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure>\n\n<p><\/p>\n\n<p><strong>ANALYSIERTE VARIANTEN:<\/strong> rs143383, rs6976, rs4836732, rs9350591, rs10492367, rs835487, rs11842874<\/p>\n\n<p><strong>ZUS\u00c4TZLICHE RESSOURCEN:<\/strong><br\/><a href=\"https:\/\/www.arthritis.org\/about-arthritis\/types\/osteoarthritis\/\">Arthrose<\/a><br\/><a href=\"https:\/\/en.wikipedia.org\/wiki\/GNL3\">GNL3<\/a><br\/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Chondrocyte\">Chondrozyten (Knorpelzellen)<\/a><\/p>\n\n<p><strong>W\u00d6CHENTLICHES UPDATE:<\/strong> 23. Juli 2019<\/p>\n","protected":false},"excerpt":{"rendered":"<p>STUDIENTITEL: Identifizierung neuer Anf\u00e4lligkeitsorte f\u00fcr Arthrose (arcOGEN): eine genomweite Assoziationsstudie ZUSAMMENFASSUNG: Eine genetische Variante des GNL3-Gens kann das Risiko f\u00fcr Arthrose erh\u00f6hen. BESCHREIBUNG: Arthrose ist die weltweit h\u00e4ufigste Form von Arthritis. Es wird auch als &#8222;Verschlei\u00df&#8220; Arthritis bezeichnet und tritt &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/de\/genetik-arthrose-arcogen-konsortium-2012\/\"> <span class=\"screen-reader-text\">Arthrose (arcOGEN Consortium, 2012)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5226,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10416","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.13 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Die Genetik der Arthrose (arcOGEN Consortium, 2012)<\/title>\n<meta name=\"description\" content=\"Arthrose ist die weltweit h\u00e4ufigste Form von Arthritis. Eine genetische Variante des GNL3-Gens kann das Risiko f\u00fcr die Entwicklung dieses Zustands erh\u00f6hen.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/de\/genetik-arthrose-arcogen-konsortium-2012\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Die Genetik der Arthrose (arcOGEN Consortium, 2012)\" \/>\n<meta property=\"og:description\" content=\"Arthrose ist die weltweit h\u00e4ufigste Form von Arthritis. 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