{"id":10474,"date":"2021-01-06T00:28:56","date_gmt":"2021-01-06T05:28:56","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-psoriasis-tsoi-2015\/"},"modified":"2021-02-20T20:49:43","modified_gmt":"2021-02-21T01:49:43","slug":"genetik-der-psoriasis-tsoi-2015","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-psoriasis-tsoi-2015\/","title":{"rendered":"Psoriasis (Tsoi, 2015)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Verbesserte Metaanalyse- und Replikationsstudien identifizieren f\u00fcnf neue Psoriasis-Anf\u00e4lligkeitsorte<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Mit dem Immunsystem verbundene genetische Varianten sind mit Psoriasis assoziiert.<\/p>\n\n

BESCHREIBUNG:<\/strong> Psoriasis ist eine Erkrankung, bei der sich zus\u00e4tzliche Hautzellen auf der Hautoberfl\u00e4che ansammeln, wodurch sich Schuppen und juckende rote Flecken bilden. Um genetische Varianten, die zu einem erh\u00f6hten Risiko f\u00fcr die Entwicklung dieser Erkrankung f\u00fchren, besser zu verstehen, wurden in dieser Studie 10.740 Personen europ\u00e4ischer Abstammung untersucht. Diese Studie identifizierte 6 genetische Varianten, die das Risiko einer Psoriasis erh\u00f6hen k\u00f6nnen. Keine dieser Varianten befand sich in Protein-kodierenden Regionen: 3 waren intronisch und 3 waren intergen. Ein Intron ist eine DNA-Sequenz, die Gene unterbricht und nicht zur Herstellung von Proteinen verwendet wird. Eine intergene Region ist genau das, was der Name andeutet – eine Strecke von DNA-Sequenzen zwischen Genen. Die meisten Varianten befanden sich in der N\u00e4he von Genen, die am Immunsystem und an Entz\u00fcndungen beteiligt sind, was darauf hindeutet, dass diese Varianten eine Rolle bei der Regulierung dieser Prozesse spielen k\u00f6nnten.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Die Verwendung von Feuchtigkeitslotionen, die Vermeidung von trockenem oder kaltem Wetter und die Verwendung eines Luftbefeuchters in Ihrem Haus k\u00f6nnen dazu beitragen, das Auftreten von Psoriasis-Sch\u00fcben zu verhindern. [ QUELLE<\/a> ]]<\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> .<\/p>\n\n

\"Psoriasis-Beispielbericht.\"<\/a><\/figure>\n\n

<\/p>\n\n

PSORIASIS-ASSOZIIERTE VARIANTEN:<\/strong> rs7637230, rs2675662, rs4685408, rs114934997, rs10789285, rs35343117<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong> Psoriasis \u00dcbersicht<\/a>Intron<\/a>Intergen<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 23. Juli 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Verbesserte Metaanalyse- und Replikationsstudien identifizieren f\u00fcnf neue Psoriasis-Anf\u00e4lligkeitsorte ZUSAMMENFASSUNG: Mit dem Immunsystem verbundene genetische Varianten sind mit Psoriasis assoziiert. BESCHREIBUNG: Psoriasis ist eine Erkrankung, bei der sich zus\u00e4tzliche Hautzellen auf der Hautoberfl\u00e4che ansammeln, wodurch sich Schuppen und juckende rote …<\/p>\n

Psoriasis (Tsoi, 2015)<\/span> Read More 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