{"id":10615,"date":"2021-01-06T00:31:49","date_gmt":"2021-01-06T05:31:49","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-des-restless-leg-syndroms-winkelmann-2011\/"},"modified":"2021-02-20T20:40:44","modified_gmt":"2021-02-21T01:40:44","slug":"genetik-des-restless-leg-syndroms-winkelmann-2011","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-des-restless-leg-syndroms-winkelmann-2011\/","title":{"rendered":"Restless Leg Syndrom (Winkelmann, 2011)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Genomweite Assoziationsstudie identifiziert neuartige Anf\u00e4lligkeitsorte f\u00fcr das Restless-Legs-Syndrom auf 2p14 und 16q12.1<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Das Restless-Leg-Syndrom ist mit Varianten in der N\u00e4he des MEIS1-Gens und des TOX3-Gens assoziiert.<\/p>\n\n

BESCHREIBUNG:<\/strong> Das Restless-Leg-Syndrom verursacht unangenehme Empfindungen in den Beinen und einen unwiderstehlichen Drang, sie zu bewegen. Dies betrifft den Patienten am h\u00e4ufigsten nachts, was es schwierig macht, gut zu schlafen. W\u00e4hrend fr\u00fchere genomweite Studien Varianten entdeckt haben, die mit diesem Zustand korrelieren, erkl\u00e4ren sie nicht die gesamte Heritabilit\u00e4t. Diese genomweite Assoziationsstudie identifizierte genetische Varianten, die mit diesem Syndrom verbunden sind, indem 2.448 Personen europ\u00e4ischer Abstammung untersucht wurden. Zwei genetische Varianten erwiesen sich als hoch signifikant – eine in einem Intron (nichtkodierende Region) in der N\u00e4he des MEIS1-Gens und die andere im TOX3-Gen. Das Produkt des TOX3-Gens ist am Abwickeln von DNA beteiligt, um andere Gene zu aktivieren. Das MEIS1-Gen codiert ein Protein, das die Aktivit\u00e4t anderer Gene reguliert und f\u00fcr die Produktion von Blutzellen ben\u00f6tigt wird.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Zus\u00e4tzlich zur Einnahme von Medikamenten k\u00f6nnen die Symptome dieses Syndroms gelindert werden, indem Sie ein warmes Bad nehmen, Ihre Beinmuskeln massieren, trainieren, Koffein meiden und einen guten Schlafplan haben. [ QUELLE<\/a> ]]<\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> .<\/p>\n\n

\"Beispiel<\/a><\/figure>\n\n

<\/p>\n\n

RESTLESS LEG-ASSOCIATED VARIANTS:<\/strong> rs2300478, rs12593813, rs9357271, rs3104767, rs6747972, rs1975197<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong> Datenbl\u00e4tter zum Restless-Leg-Syndrom<\/a>Exons und Introns<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 23. Juli 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Genomweite Assoziationsstudie identifiziert neuartige Anf\u00e4lligkeitsorte f\u00fcr das Restless-Legs-Syndrom auf 2p14 und 16q12.1 ZUSAMMENFASSUNG: Das Restless-Leg-Syndrom ist mit Varianten in der N\u00e4he des MEIS1-Gens und des TOX3-Gens assoziiert. BESCHREIBUNG: Das Restless-Leg-Syndrom verursacht unangenehme Empfindungen in den Beinen und einen unwiderstehlichen …<\/p>\n

Restless Leg Syndrom (Winkelmann, 2011)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5571,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10615","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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