{"id":10887,"date":"2021-01-06T00:37:16","date_gmt":"2021-01-06T05:37:16","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-nikotin-abhaengigkeit-quach-2020\/"},"modified":"2021-02-20T20:25:18","modified_gmt":"2021-02-21T01:25:18","slug":"genetik-nikotin-abhaengigkeit-quach-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-nikotin-abhaengigkeit-quach-2020\/","title":{"rendered":"Nikotinabh\u00e4ngigkeit (Quach, 2020)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Erweiterung der genetischen Architektur der Nikotinabh\u00e4ngigkeit und ihrer gemeinsamen Genetik um mehrere Merkmale<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Entdeckung von 5 Genomregionen im Zusammenhang mit Nikotinabh\u00e4ngigkeit.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Nikotin ist eine Chemikalie, die h\u00e4ufig in Tabakerzeugnissen wie Zigaretten, Zigarren und E-Zigaretten (Vapes) vorkommt. Viele Raucher sind auf Nikotin angewiesen. Anzeichen von Abh\u00e4ngigkeit sind Stimmungsschwankungen, Angstzust\u00e4nde und Unruhe nach dem Versuch, aufzuh\u00f6ren. Die Nikotinabh\u00e4ngigkeit ist ein hoch vererbbares Merkmal, aber bisher wurden nur sehr wenige assoziierte Genomregionen entdeckt. Diese Studie untersuchte \u00fcber 58.000 Raucher europ\u00e4ischer und afrikanischer Abstammung und identifizierte 5 Regionen des Genoms, die mit der Nikotinabh\u00e4ngigkeit zusammenh\u00e4ngen. Zwei dieser Regionen wurden neu entdeckt. Einer von ihnen beherbergt ein Gen namens TENM2, das eine Rolle bei der Bildung von Verbindungen zwischen Nervenzellen im Gehirn spielt. Die Studie fand auch genetische Korrelationen zwischen Nikotinabh\u00e4ngigkeit und Alkoholabh\u00e4ngigkeit sowie psychischen Erkrankungen wie bipolaren St\u00f6rungen, Schizophrenie und Depressionen.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Nikotin bewirkt die Freisetzung von Dopamin im Gehirn, das f\u00fcr die \u201eWohlf\u00fchl\u201c -Emotionen verantwortlich ist. Mit der Zeit wird die Freisetzung von Dopamin im Gehirn jedoch vom Nikotinkonsum abh\u00e4ngig. Dies schafft eine Verbindung zwischen Rauchen und Depression. Eine Studie im Vereinigten K\u00f6nigreich ergab beispielsweise, dass Erwachsene mit Depressionen doppelt so h\u00e4ufig rauchen wie Erwachsene, die nicht an Depressionen leiden. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> .<\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

<\/p>\n\n

ADDICTION-ASSOZIIERTE VARIANTEN:<\/strong> rs16969968, rs151176846, rs13284520, rs1862416, rs2714700<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Wie Nikotin wirkt<\/a>Nikotinabh\u00e4ngigkeit – Wie kommt es?<\/a><\/p>\n\n

SIE K\u00d6NNEN AUCH INTERESSIERT SEIN an:<\/strong> Alkoholkonsum (Jorgenson, 2017)<\/a>Lungenkrebs (McKay, 2017)<\/a>Spielst\u00f6rungen (Lind, 2012)<\/a>Cannabiskonsumst\u00f6rung (Demontis, 2019)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 12. November 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Erweiterung der genetischen Architektur der Nikotinabh\u00e4ngigkeit und ihrer gemeinsamen Genetik um mehrere Merkmale ZUSAMMENFASSUNG: Entdeckung von 5 Genomregionen im Zusammenhang mit Nikotinabh\u00e4ngigkeit. \u00dcBERBLICK: Nikotin ist eine Chemikalie, die h\u00e4ufig in Tabakerzeugnissen wie Zigaretten, Zigarren und E-Zigaretten (Vapes) vorkommt. Viele …<\/p>\n

Nikotinabh\u00e4ngigkeit (Quach, 2020)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":7221,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-10887","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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