{"id":9910,"date":"2021-01-06T00:02:51","date_gmt":"2021-01-06T05:02:51","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-mosaik-verlust-von-chromosom-y-terao-2019\/"},"modified":"2021-02-20T20:42:00","modified_gmt":"2021-02-21T01:42:00","slug":"genetik-mosaik-verlust-von-chromosom-y-terao-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-mosaik-verlust-von-chromosom-y-terao-2019\/","title":{"rendered":"Mosaikverlust von Chromosom Y (Terao, 2019)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> GWAS des Mosaikverlustes von Chromosom Y zeigt genetische Effekte auf die Differenzierung von Blutzellen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 46 genetischen Varianten, die mit dem Mosaikverlust von Chromosom Y (mLOY) assoziiert sind.<\/p>\n\n

BESCHREIBUNG:<\/strong> Zellen im menschlichen K\u00f6rper speichern genetische Informationen in 23 Chromosomenpaaren. mLOY ist eine m\u00e4nnerspezifische Erkrankung, die durch den Verlust von Chromosom Y durch einige Zellen gekennzeichnet ist. mLOY wurde mit verschiedenen Erkrankungen in Verbindung gebracht, einschlie\u00dflich Krebs, und wird am h\u00e4ufigsten in den wei\u00dfen Blutk\u00f6rperchen alternder M\u00e4nner beobachtet. Diese genomweite Assoziationsstudie analysierte die genetischen Daten von 95.380 japanischen M\u00e4nnern, um die genetischen Faktoren, die zu dieser Erkrankung beitragen, besser zu verstehen. Die Studie entdeckte 46 genetische Varianten, von denen 35 neu sind, und zusammen erkl\u00e4ren diese Varianten gesch\u00e4tzte 9% der Heritabilit\u00e4t von mLOY. Viele der identifizierten genetischen Varianten befinden sich in der N\u00e4he von Genen, die in Blutstammzellen aktiv sind.<\/p>\n\n

HAST DU GEWUSST?<\/strong> Studien haben gezeigt, dass Rauchen das Risiko eines Mosaikverlusts von Chromosom Y signifikant erh\u00f6hen kann. Es gibt gute Nachrichten f\u00fcr Raucher, die mit dem Rauchen aufh\u00f6ren m\u00f6chten. Dieselben Untersuchungen haben gezeigt, dass fr\u00fchere Raucher keinen h\u00f6heren Y-Chromosomenverlust hatten als Nie-Raucher. [ QUELLE<\/a> ]]<\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> .<\/p>\n\n

\"Beispiel<\/a><\/figure>\n\n

mlOY-ASSOZIIERTE VARIANTEN:<\/strong> rs56116444, rs80277818, rs2842873, rs72698721, rs59543286, rs4709819, rs227079, rs4721217, rs2237896, rs78997619, rs55727837, rs34324, rs11769630, rs4681200, rs4683900, rs10849448, rs728739, rs871134, rs35355140, rs138423884, rs34468831, rs10948011, rs9921295, rs17049722, rs11251, rs77406149, rs2646425, rs2811487, rs1859259, rs12668837, rs34778241, rs2853677, rs9299129, rs527504, rs77874075, rs10692222, rs548509555, rs117587217, rs201753350, rs12225799, rs79058858, rs74843651, rs189309686, rs2804301, rs2979469<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong> Geschlechtschromosomen<\/a>H\u00e4matopoetische Stammzelle<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 24. Oktober 2019<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: GWAS des Mosaikverlustes von Chromosom Y zeigt genetische Effekte auf die Differenzierung von Blutzellen ZUSAMMENFASSUNG: Identifizierung von 46 genetischen Varianten, die mit dem Mosaikverlust von Chromosom Y (mLOY) assoziiert sind. BESCHREIBUNG: Zellen im menschlichen K\u00f6rper speichern genetische Informationen in …<\/p>\n

Mosaikverlust von Chromosom Y (Terao, 2019)<\/span> Read More 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