{"id":9920,"date":"2021-01-06T00:02:59","date_gmt":"2021-01-06T05:02:59","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-von-hiv-samson-1996\/"},"modified":"2021-02-20T20:49:16","modified_gmt":"2021-02-21T01:49:16","slug":"genetik-von-hiv-samson-1996","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-von-hiv-samson-1996\/","title":{"rendered":"HIV-Resistenz (Samson, 1996)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Resistenz gegen HIV-1-Infektion bei kaukasischen Individuen, die mutierte Allele des CCR-5-Chemokinrezeptor-Gens tragen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung einer h\u00e4ufigen genetischen Variante, die eine Resistenz gegen das humane Immundefizienzvirus (HIV) verleiht.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Das Human Immunodeficiency Virus (HIV) zerst\u00f6rt das Immunsystem, indem es wei\u00dfe Blutk\u00f6rperchen abt\u00f6tet, die zur Bek\u00e4mpfung von Infektionen ben\u00f6tigt werden. Diese Krankheit wird als erworbenes Immunschw\u00e4chesyndrom (AIDS) bezeichnet. CCR5 ist ein Protein auf der Oberfl\u00e4che wei\u00dfer Blutk\u00f6rperchen, das von HIV gebunden wird und zum Eintritt in die Zellen verwendet wird. Diese Studie untersuchte das CCR5-Gen bei \u00fcber 1400 Personen europ\u00e4ischer Abstammung, um genetische Varianten zu finden, die mit dem Risiko einer HIV-Infektion in Verbindung gebracht werden k\u00f6nnen. Die Studie ergab, dass eine relativ h\u00e4ufige Variante (eine Deletion von 32 Basen) eine nahezu vollst\u00e4ndige Resistenz gegen eine HIV-Infektion verleiht, wenn sie in beiden Kopien des CCR5-Gens vorhanden ist. Ein CCR5-Protein, das diese Variante enth\u00e4lt, kann von HIV offenbar nicht effizient zum Eintritt in wei\u00dfe Blutk\u00f6rperchen verwendet werden.<\/p>\n\n

HAST DU GEWUSST?<\/strong> W\u00e4hrend die genetische Variante des CCR5-Gens, die HIV-Resistenz verleiht, bei Personen europ\u00e4ischer Abstammung relativ h\u00e4ufig ist, wird sie bei Personen afrikanischer Abstammung nicht gefunden. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

<\/p>\n\n

ANALYSIERTE VARIANTEN:<\/strong> rs333<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Was sind HIV und AIDS?<\/a>HIV & AIDS (Video)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 15. Februar 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Resistenz gegen HIV-1-Infektion bei kaukasischen Individuen, die mutierte Allele des CCR-5-Chemokinrezeptor-Gens tragen ZUSAMMENFASSUNG: Identifizierung einer h\u00e4ufigen genetischen Variante, die eine Resistenz gegen das humane Immundefizienzvirus (HIV) verleiht. \u00dcBERBLICK: Das Human Immunodeficiency Virus (HIV) zerst\u00f6rt das Immunsystem, indem es wei\u00dfe …<\/p>\n

HIV-Resistenz (Samson, 1996)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5791,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-9920","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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