{"id":9923,"date":"2021-01-06T00:03:03","date_gmt":"2021-01-06T05:03:03","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetik-der-telomer-laenge-codd-2013\/"},"modified":"2021-02-20T20:36:09","modified_gmt":"2021-02-21T01:36:09","slug":"genetik-der-telomer-laenge-codd-2013","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/de\/genetik-der-telomer-laenge-codd-2013\/","title":{"rendered":"Telomerl\u00e4nge (Codd, 2013)"},"content":{"rendered":"\n

STUDIENTITEL:<\/strong> Identifizierung von sieben Loci, die die mittlere Telomerl\u00e4nge und ihre Assoziation mit der Krankheit beeinflussen<\/a><\/p>\n\n

ZUSAMMENFASSUNG:<\/strong> Identifizierung von 5 neuen genetischen Regionen, die mit der L\u00e4nge der Telomere zusammenh\u00e4ngen.<\/p>\n\n

\u00dcBERBLICK:<\/strong> Die DNA in unseren Zellen ist dicht in Strukturen gepackt, die als Chromosomen bezeichnet werden. Die Sequenzen an den Enden der Chromosomen bilden Kappen, die als Telomere bekannt sind. Diese Strukturen tragen zum Schutz unserer Chromosomen bei, \u00e4hnlich wie die Plastikspitzen an den Schn\u00fcrsenkeln die Enden vor dem Ausfransen sch\u00fctzen. Bei vielen Zellteilungen, bei denen die gesamte DNA einer Zelle kopiert wird, werden die Telomere zunehmend k\u00fcrzer, bis die DNA besch\u00e4digt wird und die Zellen schlie\u00dflich sterben. Es wird gesch\u00e4tzt, dass bis zu 80% der Telomerl\u00e4nge eines Individuums vererbbar sind. Kurze Telomere wurden mit einem erh\u00f6hten Risiko f\u00fcr mehrere altersbedingte Krankheiten in Verbindung gebracht. Die Telomerl\u00e4nge wurde auch mit Krebs in Verbindung gebracht, aber die Wirkungsrichtung dieser Assoziation ist weniger klar. Diese Studie untersuchte genetische Daten von fast 50.000 Personen europ\u00e4ischer Abstammung und identifizierte 7 genetische Regionen, die mit der Telomerl\u00e4nge assoziiert sind, von denen 5 neu sind. Die genetische Variation in diesen Regionen erkl\u00e4rt zusammen \u00fcber 1% der Varianz in der Telomerl\u00e4nge.<\/p>\n\n

HAST DU GEWUSST?<\/strong> W\u00e4hrend sich unsere Telomere im Laufe unseres Lebens auf nat\u00fcrliche Weise verk\u00fcrzen, ist bekannt, dass einige Lebensstilentscheidungen diesen Prozess beschleunigen! Insbesondere Rauchen und UV-Exposition k\u00f6nnen die Verk\u00fcrzung der Telomere beschleunigen und die Anf\u00e4lligkeit f\u00fcr verschiedene Krankheiten erh\u00f6hen. [SOURCE]<\/a><\/p>\n\n

BEISPIELERGEBNISSE:<\/strong> Erfahren Sie mehr \u00fcber die Nebula Research Library<\/a> . <\/p>\n\n

\"Ergebnisse<\/a><\/figure>\n\n

<\/p>\n\n

ANALYSIERTE VARIANTEN:<\/strong> rs10936599, rs2736100, rs7675998, rs9420907, rs8105767, rs755017, rs11125529<\/p>\n\n

ZUS\u00c4TZLICHE RESSOURCEN:<\/strong>Telomere<\/a>Die Wissenschaft von Zellen, die niemals alt werden (Video)<\/a><\/p>\n\n

W\u00d6CHENTLICHES UPDATE:<\/strong> 15. Februar 2020<\/p>\n\n

M\u00f6chten Sie mehr \u00fcber Ihre Telomerl\u00e4nge erfahren? Das k\u00f6nnte dir gefallen TeloJahre<\/a> Rezension.<\/p>\n","protected":false},"excerpt":{"rendered":"

STUDIENTITEL: Identifizierung von sieben Loci, die die mittlere Telomerl\u00e4nge und ihre Assoziation mit der Krankheit beeinflussen ZUSAMMENFASSUNG: Identifizierung von 5 neuen genetischen Regionen, die mit der L\u00e4nge der Telomere zusammenh\u00e4ngen. \u00dcBERBLICK: Die DNA in unseren Zellen ist dicht in Strukturen …<\/p>\n

Telomerl\u00e4nge (Codd, 2013)<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5801,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4980],"tags":[],"class_list":["post-9923","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-berichte"],"yoast_head":"\nDie 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