{"id":10008,"date":"2021-01-06T00:04:13","date_gmt":"2021-01-06T05:04:13","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-calculos-biliares-ferkingstad-2018\/"},"modified":"2021-02-20T20:32:22","modified_gmt":"2021-02-21T01:32:22","slug":"genetica-de-calculos-biliares-ferkingstad-2018","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-de-calculos-biliares-ferkingstad-2018\/","title":{"rendered":"C\u00e1lculos biliares (Ferkingstad, 2018)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> El metan\u00e1lisis de asociaci\u00f3n de todo el genoma arroja 20 loci asociados con la enfermedad de c\u00e1lculos biliares<\/a><\/p>\n\n

RESUMEN:<\/strong> Descubrimiento de 21 regiones gen\u00f3micas asociadas con la formaci\u00f3n de c\u00e1lculos biliares. <\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> La ves\u00edcula biliar almacena un l\u00edquido llamado bilis. Libera bilis en los intestinos donde ayuda con la digesti\u00f3n. La bilis contiene \u00e1cidos biliares que se producen en el cuerpo a partir del colesterol. Los c\u00e1lculos biliares son c\u00e1lculos que se pueden formar en la ves\u00edcula biliar cuando hay demasiado colesterol y no hay suficientes \u00e1cidos biliares. Los c\u00e1lculos pueden causar dolor en la parte superior derecha del abdomen y pueden requerir cirug\u00eda. Para identificar las variantes gen\u00e9ticas asociadas con la formaci\u00f3n de c\u00e1lculos biliares, este estudio de asociaci\u00f3n de todo el genoma examin\u00f3 los genomas de m\u00e1s de 750.000 individuos de ascendencia europea. El estudio identific\u00f3 28 regiones gen\u00f3micas asociadas con la enfermedad de c\u00e1lculos biliares, 21 de las cuales son nuevas. Algunas de estas variantes gen\u00e9ticas se han relacionado previamente con la diabetes y el metabolismo de las grasas. <\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Seg\u00fan los Guinness World Records, la mayor\u00eda de los c\u00e1lculos biliares extra\u00eddos de un paciente fueron ~ 24.000. Por el contrario, la mayor\u00eda de los pacientes que se someten a cirug\u00eda por c\u00e1lculos biliares tienen, en promedio, de 2 a 20. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS CON GALLSTONE:<\/strong> rs11887534, rs212100, rs12633863, rs4148808, rs2291428, rs2290846, rs1800961, rs6471717, rs601338, rs686030, rs756082276, rs28929474, rs1260326, rs34851490, rs1169288, rs756935975, rs13280055, rs56398830, rs174567, rs708686, rs11012737, rs1935, rs2469991, rs17240268, rs2070959, rs12004, rs55971546, rs11641445, rs17138478, rs45575636, rs2292553, rs12968116<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>C\u00e1lculos biliares (video)<\/a> Enfermedad de c\u00e1lculos biliares<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 28 de abril de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: El metan\u00e1lisis de asociaci\u00f3n de todo el genoma arroja 20 loci asociados con la enfermedad de c\u00e1lculos biliares RESUMEN: Descubrimiento de 21 regiones gen\u00f3micas asociadas con la formaci\u00f3n de c\u00e1lculos biliares. VISI\u00d3N GENERAL: La ves\u00edcula biliar almacena …<\/p>\n

C\u00e1lculos biliares (Ferkingstad, 2018)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6274,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10008","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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