{"id":10011,"date":"2021-01-06T00:04:20","date_gmt":"2021-01-06T05:04:20","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-dermatitis-atopica-paternoster-2015\/"},"modified":"2021-02-20T20:25:37","modified_gmt":"2021-02-21T01:25:37","slug":"genetica-de-dermatitis-atopica-paternoster-2015","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-de-dermatitis-atopica-paternoster-2015\/","title":{"rendered":"Dermatitis at\u00f3pica (Paternoster, 2015)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> El estudio de asociaci\u00f3n de m\u00faltiples ancestros en todo el genoma de 21.000 casos y 95.000 controles identifica nuevos loci de riesgo para la dermatitis at\u00f3pica<\/a><\/p>\n\n

RESUMEN:<\/strong> Descubrimiento de 10 nuevas regiones gen\u00f3micas asociadas con la dermatitis at\u00f3pica, tambi\u00e9n conocida como eccema.<\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> La piel es el \u00f3rgano m\u00e1s grande del cuerpo y act\u00faa como barrera al mundo exterior. El sistema inmunol\u00f3gico ayuda a mantener esta funci\u00f3n de barrera, atacando las sustancias \u00abextra\u00f1as\u00bb que entran en contacto con la piel. Cuando esto sucede, la piel puede inflamarse, enrojecerse y picar. La dermatitis at\u00f3pica (DA), tambi\u00e9n conocida como eccema, es una inflamaci\u00f3n de la piel provocada por factores ambientales que en realidad no son da\u00f1inos para el cuerpo. Entre muchos otros, estos factores pueden incluir temperatura, jab\u00f3n y ropa. La EA es altamente heredable, y la gen\u00e9tica determina hasta el 90% de la susceptibilidad de un individuo a la afecci\u00f3n. Para identificar variantes gen\u00e9ticas que est\u00e1n asociadas con la dermatitis at\u00f3pica, este estudio de asociaci\u00f3n de todo el genoma examin\u00f3 a m\u00e1s de 116.000 individuos de ascendencia europea, africana, japonesa y latina. El estudio encontr\u00f3 21 regiones del genoma asociadas con la dermatitis at\u00f3pica, 10 de las cuales son nuevas. En conjunto, estas variantes pueden explicar alrededor del 15% de la variaci\u00f3n en la susceptibilidad a la EA. Las regiones gen\u00f3micas identificadas recientemente incluyen genes involucrados en el sistema inmunol\u00f3gico, particularmente la funci\u00f3n de las c\u00e9lulas T que juegan un papel importante en muchas enfermedades autoinmunes. <\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> La dermatitis at\u00f3pica puede ser una condici\u00f3n persistente, con brotes que ocurren peri\u00f3dicamente. Para ayudar a reducir la gravedad y la frecuencia de los s\u00edntomas, es fundamental un buen cuidado de la piel. Esto incluye la aplicaci\u00f3n regular de un humectante, usar un detergente para ropa \u00absin olor\u00bb y evitar rascarse la piel con picaz\u00f3n. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS A AD:<\/strong> rs61813875, rs10791824, rs12188917, rs6419573, rs2212434, rs4809219, rs2918307, rs2041733, rs12730935, rs2038255, rs7127307, rs7512552, rs647102364, rs1990, rs647102364<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>Dermatitis at\u00f3pica (video)<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 28 de abril de 2020<\/p>\n\n

Adem\u00e1s, eche un vistazo a nuestro Revisi\u00f3n de curolog\u00eda<\/a> !<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: El estudio de asociaci\u00f3n de m\u00faltiples ancestros en todo el genoma de 21.000 casos y 95.000 controles identifica nuevos loci de riesgo para la dermatitis at\u00f3pica RESUMEN: Descubrimiento de 10 nuevas regiones gen\u00f3micas asociadas con la dermatitis …<\/p>\n

Dermatitis at\u00f3pica (Paternoster, 2015)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6284,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10011","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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