{"id":10036,"date":"2021-01-06T00:05:56","date_gmt":"2021-01-06T05:05:56","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-del-sindrome-de-sjogrens-lessard-2013\/"},"modified":"2021-02-20T20:25:26","modified_gmt":"2021-02-21T01:25:26","slug":"genetica-del-sindrome-de-sjogrens-lessard-2013","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-del-sindrome-de-sjogrens-lessard-2013\/","title":{"rendered":"S\u00edndrome de Sj\u00f6gren (Lessard, 2013)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> Variantes en m\u00faltiples loci implicados en respuestas inmunes tanto innatas como adaptativas est\u00e1n asociadas con el s\u00edndrome de Sj\u00f6gren<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de 7 regiones gen\u00f3micas asociadas al riesgo de s\u00edndrome de Sj\u00f6gren. <\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> El s\u00edndrome de Sj\u00f6gren es un trastorno autoinmune caracterizado por ojos secos y boca seca. Ocurre cuando el sistema inmunol\u00f3gico del cuerpo ataca por error las gl\u00e1ndulas, como las que producen saliva y l\u00e1grimas. Como resultado, estas gl\u00e1ndulas se inflaman y se da\u00f1an. Hasta 3 millones de personas solo en los Estados Unidos pueden verse afectadas por el s\u00edndrome de Sj\u00f6gren. Si bien la afecci\u00f3n puede afectar a personas de cualquier edad, se diagnostica con mayor frecuencia en mujeres mayores. Para comprender mejor la gen\u00e9tica que puede predisponer a una persona a la afecci\u00f3n, este estudio de asociaci\u00f3n de todo el genoma examin\u00f3 a casi 8.400 personas de ascendencia europea. El estudio encontr\u00f3 7 regiones del genoma asociadas con la susceptibilidad a desarrollar el s\u00edndrome de Sj\u00f6gren. Los genes ubicados en estas regiones juegan un papel en el funcionamiento del sistema inmunol\u00f3gico, incluida la producci\u00f3n de prote\u00ednas de interfer\u00f3n que promueven la inflamaci\u00f3n. Juntas, las variantes identificadas pueden explicar una gran proporci\u00f3n del riesgo hereditario de la enfermedad. <\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Como resultado de la boca seca causada por el s\u00edndrome de Sj\u00f6gren, las personas afectadas tienen un mayor riesgo de desarrollar caries y p\u00e9rdida de dientes. Se recomienda encarecidamente el cuidado dental regular a las personas que viven con la afecci\u00f3n. Tambi\u00e9n pueden ayudar beber agua, masticar chicle y otros m\u00e9todos para estimular la producci\u00f3n de saliva. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"Resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS AL S\u00cdNDROME DE SJ\u00d6GREN:<\/strong> rs9271588, rs3757387, rs10553577, rs485497, rs2736345, rs7119038, rs6579837<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>S\u00edndrome de Sj\u00f6gren (video)<\/a> <\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 5 de mayo de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: Variantes en m\u00faltiples loci implicados en respuestas inmunes tanto innatas como adaptativas est\u00e1n asociadas con el s\u00edndrome de Sj\u00f6gren RESUMEN: Identificaci\u00f3n de 7 regiones gen\u00f3micas asociadas al riesgo de s\u00edndrome de Sj\u00f6gren. VISI\u00d3N GENERAL: El s\u00edndrome de …<\/p>\n

S\u00edndrome de Sj\u00f6gren (Lessard, 2013)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6324,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10036","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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