{"id":10064,"date":"2021-01-06T00:06:32","date_gmt":"2021-01-06T05:06:32","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-adelgazamiento-cornea-choquet-2020\/"},"modified":"2021-02-20T20:26:42","modified_gmt":"2021-02-21T01:26:42","slug":"genetica-de-adelgazamiento-cornea-choquet-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-de-adelgazamiento-cornea-choquet-2020\/","title":{"rendered":"Espesor corneal (Choquet, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> Un an\u00e1lisis multi\u00e9tnico de todo el genoma de 44.039 individuos identifica 41 nuevos loci asociados con el grosor corneal central<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de m\u00e1s de 40 nuevas variantes gen\u00e9ticas asociadas con el grosor corneal central, que est\u00e1 vinculado a m\u00faltiples trastornos del ojo.<\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> La c\u00f3rnea act\u00faa como una \u201cventana\u201d para el ojo, permitiendo que la luz entre al mismo tiempo que act\u00faa como una barrera contra irritantes extra\u00f1os. El grosor de la c\u00f3rnea es un indicador bien estudiado de la salud ocular, y la reducci\u00f3n del grosor se ha relacionado con enfermedades oculares como el glaucoma. Este estudio de asociaci\u00f3n de todo el genoma tuvo como objetivo identificar las regiones gen\u00f3micas vinculadas al grosor en el centro de la c\u00f3rnea. Al examinar la informaci\u00f3n gen\u00e9tica de m\u00e1s de 44,000 individuos de etnia blanca, hispana, asi\u00e1tica y afroamericana no hispana, el estudio encontr\u00f3 98 regiones del genoma asociadas con el grosor corneal central. De estos, 41 fueron nuevos para este estudio. Juntas, todas las variantes de este estudio pueden explicar alrededor del 14% de la variaci\u00f3n individual en el grosor corneal central. Tambi\u00e9n se descubri\u00f3 que algunas de estas variantes identificadas estaban asociadas con enfermedades oculares, incluidos el queratocono y el glaucoma, lo que subraya las conexiones entre el grosor de la c\u00f3rnea y los trastornos del ojo.<\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> M\u00e1s de 2.5 millones de lesiones oculares se registran cada a\u00f1o solo en los Estados Unidos, y la mitad de ellas ocurren en el hogar. Se recomienda encarecidamente usar un par de gafas debidamente certificadas al realizar actividades que involucren herramientas o productos qu\u00edmicos peligrosos como la lej\u00eda. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS AL ESPESOR CORNEAL:<\/strong> rs28526212, rs3132303, rs121908120, rs12554217, rs930847, rs1931656, rs1828481, rs56009602, rs3132307, rs35809595, rs6910919, rs1831902, rs11111869, rs72755233, rs10471310, rs62279162, rs10980623, rs2034809, rs785429, rs12912010, rs11636578, rs17024437, rs9906577, rs13191376, rs7040970, rs13079175, rs4938174, rs9552680, rs117995094, rs4611262, rs7308752, rs9838430, rs7823059, rs34869, rs56054326, rs7026684, rs4846476, rs166474, rs56223983, rs1412710, rs2731646, rs4475548, rs75550549, rs152446, rs1176321, rs73222243, rs71313931, rs2419835, rs2320163, rs12898341, rs113896694, rs11650127, rs28667150, rs9294963, rs57168185, rs11917483, rs56303154, rs12324079, rs448203, rs62292788, rs96067, rs848546, rs25458, rs10124621, rs6459472, rs4785955, rs7211723, rs3740685, rs10800558, rs11903480, rs4311997, rs10245642, rs154001, rs10943848, rs4623781, rs7737693, rs58671886, rs1800440, rs8133436, rs2505507, rs9350413, rs688601, rs7749695, rs880930, rs117789382, rs13036662, rs35351529, rs28683756, rs 124932, rs11077857, rs9855175<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>La c\u00f3rnea<\/a><\/p>\n\n

USTED TAMBI\u00c9N PODR\u00cdA ESTAR INTERESADO EN:<\/strong> Queratocono (McComish, 2019)<\/a> Glaucoma (Craig, 2020)<\/a> Tama\u00f1o del disco \u00f3ptico (Hun, 2019)<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 25 de junio de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: Un an\u00e1lisis multi\u00e9tnico de todo el genoma de 44.039 individuos identifica 41 nuevos loci asociados con el grosor corneal central RESUMEN: Identificaci\u00f3n de m\u00e1s de 40 nuevas variantes gen\u00e9ticas asociadas con el grosor corneal central, que est\u00e1 …<\/p>\n

Espesor corneal (Choquet, 2020)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6564,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10064","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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