{"id":10149,"date":"2021-01-06T00:08:22","date_gmt":"2021-01-06T05:08:22","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-cancer-de-pulmon-mckay-2017\/"},"modified":"2021-02-20T20:23:37","modified_gmt":"2021-02-21T01:23:37","slug":"genetica-cancer-de-pulmon-mckay-2017","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-cancer-de-pulmon-mckay-2017\/","title":{"rendered":"C\u00e1ncer de pulm\u00f3n (McKay, 2017)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> El an\u00e1lisis de asociaci\u00f3n a gran escala identifica nuevos loci de susceptibilidad al c\u00e1ncer de pulm\u00f3n y heterogeneidad en la susceptibilidad gen\u00e9tica a trav\u00e9s de subtipos histol\u00f3gicos<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de 4 regiones gen\u00f3micas novedosas asociadas con el c\u00e1ncer de pulm\u00f3n. <\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> El c\u00e1ncer de pulm\u00f3n es una afecci\u00f3n en la que las c\u00e9lulas de los pulmones se dividen sin control. Es la principal causa de muerte relacionada con el c\u00e1ncer en los Estados Unidos. Hay dos tipos principales de c\u00e1ncer de pulm\u00f3n: c\u00e1ncer de pulm\u00f3n de c\u00e9lulas peque\u00f1as y c\u00e1ncer de c\u00e9lulas no peque\u00f1as, y este \u00faltimo comprende del 80 al 85% de todos los c\u00e1nceres de pulm\u00f3n. Aunque fumar es el factor de riesgo m\u00e1s com\u00fan asociado con la afecci\u00f3n, tambi\u00e9n se cree que la gen\u00e9tica juega un papel importante. Por lo tanto, al examinar ~ 85,000 genomas, este estudio tuvo como objetivo comprender los factores gen\u00e9ticos asociados con el riesgo de desarrollar este c\u00e1ncer. Los investigadores identificaron 18 variantes gen\u00e9ticas asociadas con la enfermedad, 10 de las cuales son nuevas. De las nuevas regiones, 4 est\u00e1n asociadas con el c\u00e1ncer de pulm\u00f3n en general. Algunas de estas regiones se han asociado previamente con la adicci\u00f3n y el h\u00e1bito de fumar. En general, las variantes gen\u00e9ticas identificadas ayudan a explicar el 8,9% de la heredabilidad de este c\u00e1ncer. <\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Si bien fumar es la principal causa de c\u00e1ncer de pulm\u00f3n, la exposici\u00f3n al rad\u00f3n, un gas radiactivo invisible, tambi\u00e9n contribuye al riesgo. El rad\u00f3n se libera de la descomposici\u00f3n normal de los elementos uranio, torio y radio en las rocas y el suelo. Las casas construidas sobre suelos ricos en estos elementos pueden tener niveles m\u00e1s altos de rad\u00f3n en el aire. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS AL ESTUDIO:<\/strong> rs55781567, rs56113850, rs11571833, rs71658797, rs6920364, rs11780471, rs66759488<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>C\u00e1ncer en los pulmones (video)<\/a> Tipos de c\u00e1ncer de pulm\u00f3n<\/a>Viviendo con c\u00e1ncer de pulm\u00f3n<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 12 de mayo de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: El an\u00e1lisis de asociaci\u00f3n a gran escala identifica nuevos loci de susceptibilidad al c\u00e1ncer de pulm\u00f3n y heterogeneidad en la susceptibilidad gen\u00e9tica a trav\u00e9s de subtipos histol\u00f3gicos RESUMEN: Identificaci\u00f3n de 4 regiones gen\u00f3micas novedosas asociadas con el …<\/p>\n

C\u00e1ncer de pulm\u00f3n (McKay, 2017)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6354,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10149","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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