{"id":10153,"date":"2021-01-06T00:08:25","date_gmt":"2021-01-06T05:08:25","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-melanoma-landi-2020\/"},"modified":"2021-02-20T20:25:33","modified_gmt":"2021-02-21T01:25:33","slug":"genetica-melanoma-landi-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-melanoma-landi-2020\/","title":{"rendered":"Melanoma (Landi, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> Los metan\u00e1lisis de asociaci\u00f3n de todo el genoma que combinan fenotipos de riesgo m\u00faltiple proporcionan informaci\u00f3n sobre la arquitectura gen\u00e9tica de la susceptibilidad al melanoma cut\u00e1neo<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de 54 regiones gen\u00f3micas asociadas con el riesgo de melanoma. <\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> El melanoma es el tipo de c\u00e1ncer de piel m\u00e1s grave. Este estudio compar\u00f3 ~ 36,000 pacientes con melanoma con ~ 375,000 individuos sanos de ascendencia europea e identific\u00f3 68 variantes gen\u00e9ticas en 54 regiones gen\u00f3micas diferentes. El estudio tambi\u00e9n encontr\u00f3 asociaciones entre el riesgo de c\u00e1ncer y un color de piel m\u00e1s claro, as\u00ed como una mayor cantidad de lunares en el cuerpo. Una de las regiones asociadas con el melanoma y los lunares est\u00e1 cerca del gen PARP1, un gen de reparaci\u00f3n del ADN que ayuda a controlar el gen MITF que causa el melanoma. Otra variante se asoci\u00f3 con la regi\u00f3n HLA, lo que sugiere un papel de la inmunidad en el desarrollo del c\u00e1ncer de piel. Otros genes participaron en el mantenimiento de los tel\u00f3meros. Las regiones gen\u00f3micas descubiertas en este estudio explican colectivamente ~ 8.5% de la heredabilidad del riesgo de esta condici\u00f3n. <\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Hay muchas se\u00f1ales de advertencia para determinar si una mancha es solo un lunar o en realidad es un melanoma. La prueba m\u00e1s f\u00e1cil se llama la prueba del \u201cpatito feo\u201d: si un lunar se ve diferente de los otros lunares de tu cuerpo, como el patito feo se ve\u00eda diferente de sus hermanos, \u00a1vale la pena que lo revisen! Los melanomas a menudo son asim\u00e9tricos, tienen bordes inusuales, tienen diferentes colores, son de gran di\u00e1metro o cambian con el tiempo. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS AL ESTUDIO:<\/strong> rs1805007, rs6059655, rs1126809, rs408825, rs16891982, rs7902587, rs871024, rs132941, rs1801516, rs117132860, rs4354713, rs1339759, rs6914598, rs10739220, rs2695237, rs13178866, rs32578, rs4731207, rs76798800, rs1800440, rs8444, rs4420522, rs149617956, rs143190905, rs72834823, rs10960710, rs12913832, rs1278768, rs117648907, rs3950296, rs10859996, rs78378222, rs12984831, rs113469387, rs4237963, rs7941496, rs5766565, rs2967383, rs1056927, rs6908626, rs6994183, rs12473635, rs12215602, rs79966207, rs7778378, rs670318, rs2369633, rs28986343, rs12539524, rs3780269, rs10931936, rs12290699, rs13263376, rs12523094<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>ABCDE para detectar melanoma (video)<\/a>De d\u00f3nde proviene el melanoma, c\u00f3mo detectarlo y c\u00f3mo prevenirlo (video)<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 12 de mayo de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: Los metan\u00e1lisis de asociaci\u00f3n de todo el genoma que combinan fenotipos de riesgo m\u00faltiple proporcionan informaci\u00f3n sobre la arquitectura gen\u00e9tica de la susceptibilidad al melanoma cut\u00e1neo RESUMEN: Identificaci\u00f3n de 54 regiones gen\u00f3micas asociadas con el riesgo de …<\/p>\n

Melanoma (Landi, 2020)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6359,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10153","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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