{"id":10171,"date":"2021-01-06T00:08:36","date_gmt":"2021-01-06T05:08:36","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-del-volumen-sistolico-pirruccello-2020\/"},"modified":"2021-02-20T20:23:52","modified_gmt":"2021-02-21T01:23:52","slug":"genetica-del-volumen-sistolico-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-del-volumen-sistolico-pirruccello-2020\/","title":{"rendered":"Volumen sist\u00f3lico (Pirruccello, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> El an\u00e1lisis de im\u00e1genes de resonancia magn\u00e9tica card\u00edaca en 36.000 personas arroja conocimientos gen\u00e9ticos sobre la miocardiopat\u00eda dilatada<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de 12 variantes gen\u00e9ticas asociadas con el volumen sist\u00f3lico del coraz\u00f3n.<\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> El coraz\u00f3n humano es un m\u00fasculo que bombea sangre por todo el cuerpo. Consta de 4 c\u00e1maras: 2 aur\u00edculas (izquierda y derecha) y 2 ventr\u00edculos (izquierda y derecha). La sangre que se ha enriquecido con ox\u00edgeno en los pulmones ingresa a la aur\u00edcula izquierda y luego fluye hacia el ventr\u00edculo izquierdo desde donde se bombea a todas las dem\u00e1s partes del cuerpo. El volumen sist\u00f3lico (SV) es una medida de cu\u00e1nta sangre se bombea fuera del ventr\u00edculo izquierdo durante cada latido. El SV promedio es de 81 ml para las mujeres y 95 ml para los hombres. Las mediciones del volumen sist\u00f3lico pueden indicar si el coraz\u00f3n bombea suficiente sangre para satisfacer las demandas del cuerpo. Este estudio de asociaci\u00f3n de todo el genoma de m\u00e1s de 36.000 individuos de ascendencia europea identific\u00f3 12 variantes gen\u00e9ticas correlacionadas con SV, incluidas variantes cercanas a genes que desempe\u00f1an un papel en la contracci\u00f3n del m\u00fasculo card\u00edaco (MYH6) y la formaci\u00f3n de vasos sangu\u00edneos (VEGFA). Juntas, estas variantes explican ~ 34% de la heredabilidad del volumen sist\u00f3lico. El estudio tambi\u00e9n encontr\u00f3 una fuerte relaci\u00f3n inversa entre la puntuaci\u00f3n polig\u00e9nica para SV m\u00e1s grande y el hipotiroidismo.<\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Durante el ejercicio, el cuerpo necesita un mayor suministro de sangre para suministrar ox\u00edgeno a los m\u00fasculos. Con el tiempo, el ejercicio puede llevar a un aumento en la eficiencia del coraz\u00f3n, bombeando m\u00e1s sangre con menos trabajo. Las actividades aer\u00f3bicas como correr y andar en bicicleta son particularmente efectivas para aumentar el volumen sist\u00f3lico. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS A SV:<\/strong> rs72967533, rs11065979, rs7573293, rs11066188, rs10400419, rs888690, rs422068, rs111721712, rs2891403, rs2146324, rs28391274, rs143384<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>El coraz\u00f3n (Video)<\/a><\/a>Volumen sist\u00f3lico y frecuencia card\u00edaca (video)<\/a><\/p>\n\n

USTED TAMBI\u00c9N PODR\u00cdA ESTAR INTERESADO EN:<\/strong> Fracci\u00f3n de eyecci\u00f3n del ventr\u00edculo izquierdo (Pirruccello, 2020)<\/a> Volumen telediast\u00f3lico del ventr\u00edculo izquierdo (Pirruccello, 2020)<\/a>Volumen telesist\u00f3lico del ventr\u00edculo izquierdo (Pirruccello, 2020)<\/a>Insuficiencia card\u00edaca (Shah, 2020)<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 19 de mayo de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: El an\u00e1lisis de im\u00e1genes de resonancia magn\u00e9tica card\u00edaca en 36.000 personas arroja conocimientos gen\u00e9ticos sobre la miocardiopat\u00eda dilatada RESUMEN: Identificaci\u00f3n de 12 variantes gen\u00e9ticas asociadas con el volumen sist\u00f3lico del coraz\u00f3n. VISI\u00d3N GENERAL: El coraz\u00f3n humano es …<\/p>\n

Volumen sist\u00f3lico (Pirruccello, 2020)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6384,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10171","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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