{"id":10605,"date":"2021-01-06T00:31:38","date_gmt":"2021-01-06T05:31:38","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-la-presion-arterial-surendran-2016\/"},"modified":"2021-02-20T20:50:39","modified_gmt":"2021-02-21T01:50:39","slug":"genetica-de-la-presion-arterial-surendran-2016","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-de-la-presion-arterial-surendran-2016\/","title":{"rendered":"Presi\u00f3n arterial (Surendran, 2016)"},"content":{"rendered":"\n<p><strong>T\u00cdTULO DEL ESTUDIO:<\/strong><a href=\"https:\/\/www.nature.com\/articles\/ng.3654\"> El metan\u00e1lisis de traspasos identifica variantes raras y comunes asociadas con la presi\u00f3n arterial y la hipertensi\u00f3n<\/a><\/p>\n\n<p><strong>RESUMEN:<\/strong> Este estudio vincula varias v\u00edas de se\u00f1alizaci\u00f3n celular con el riesgo de desarrollar hipertensi\u00f3n.<\/p>\n\n<p><strong>DESCRIPCI\u00d3N:<\/strong> La hipertensi\u00f3n, tambi\u00e9n llamada presi\u00f3n arterial alta, es un factor de riesgo importante para muchas enfermedades, incluidas las enfermedades card\u00edacas y los accidentes cerebrovasculares. Se cree que la presi\u00f3n arterial alta es altamente heredable, pero no se conocen bien los factores gen\u00e9ticos que influyen en el riesgo de hipertensi\u00f3n. Este gran metan\u00e1lisis incluy\u00f3 aproximadamente 350.000 personas e identific\u00f3 31 variantes gen\u00e9ticas novedosas asociadas con la hipertensi\u00f3n. Estas variantes ayudan a explicar ~ 2% de la heredabilidad de la hipertensi\u00f3n. Varias variantes se vincularon a la v\u00eda del transportador de portadores de solutos, que es responsable del transporte de muchas mol\u00e9culas a trav\u00e9s de las membranas celulares. La se\u00f1alizaci\u00f3n Notch y la v\u00eda de eliminaci\u00f3n del promotor de la ARN polimerasa I tambi\u00e9n ten\u00edan variantes gen\u00e9ticas asociadas con la hipertensi\u00f3n. La se\u00f1alizaci\u00f3n de Notch juega un papel en la divisi\u00f3n de las neuronas y es crucial para el desarrollo embrionario normal. La v\u00eda de eliminaci\u00f3n del promotor de la ARN polimerasa I est\u00e1 involucrada en la transcripci\u00f3n, que es parte del proceso que produce prote\u00ednas.<\/p>\n\n<p><strong>\u00bfSAB\u00cdAS?<\/strong> Un estilo de vida saludable puede ayudar a reducir su riesgo de hipertensi\u00f3n. Llevar una dieta saludable, hacer ejercicio con frecuencia y limitar el consumo de alcohol son formas de prevenir la hipertensi\u00f3n. [<a href=\"https:\/\/www.cdc.gov\/bloodpressure\/healthy_living.htm\"> FUENTE<\/a> ]<\/p>\n\n<p><strong>RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el<a href=\"https:\/\/nebula.org\/blog\/es\/nebulosa-biblioteca-desbloqueo-investigacion-genetica\/\"> Biblioteca de investigaci\u00f3n de nebulosa<\/a> .<\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/nebula.org\/free-dna-upload-analysis\/\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics-1024x375.png\" alt=\"Resultados de la muestra de presi&#xF3;n arterial.\"\/><\/a><\/figure>\n\n<p><\/p>\n\n<p><strong>VARIANTES ASOCIADAS A LA PRESI\u00d3N ARTERIAL:<\/strong> rs9349379, rs7406910, rs4387287, rs1008058, rs11229457, rs35529250, rs4728142<\/p>\n\n<p><strong>RECURSOS ADICIONALES:<\/strong> <br\/><a rel=\"noreferrer noopener\" href=\"https:\/\/www.mayoclinic.org\/diseases-conditions\/high-blood-pressure\/symptoms-causes\/syc-20373410\" target=\"_blank\">Hipertensi\u00f3n<\/a><br\/><a rel=\"noreferrer noopener\" href=\"https:\/\/en.wikipedia.org\/wiki\/Solute_carrier_family\" target=\"_blank\">Familia de transportadores de solutos<\/a><br\/><a rel=\"noreferrer noopener\" href=\"https:\/\/en.wikipedia.org\/wiki\/Notch_signaling_pathway\" target=\"_blank\">V\u00eda de se\u00f1alizaci\u00f3n de muesca<\/a><br\/><a rel=\"noreferrer noopener\" href=\"https:\/\/en.wikipedia.org\/wiki\/RNA_polymerase_I\" target=\"_blank\">ARN polimerasa I<\/a><br\/><a rel=\"noreferrer noopener\" href=\"https:\/\/reactome.org\/content\/detail\/R-HSA-73854\" target=\"_blank\">Aclaramiento del promotor de ARN polimerasa I<\/a><\/p>\n\n<p><strong>ACTUALIZACI\u00d3N SEMANAL:<\/strong> 23 de julio de 2019<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u00cdTULO DEL ESTUDIO: El metan\u00e1lisis de traspasos identifica variantes raras y comunes asociadas con la presi\u00f3n arterial y la hipertensi\u00f3n RESUMEN: Este estudio vincula varias v\u00edas de se\u00f1alizaci\u00f3n celular con el riesgo de desarrollar hipertensi\u00f3n. DESCRIPCI\u00d3N: La hipertensi\u00f3n, tambi\u00e9n llamada &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/es\/genetica-de-la-presion-arterial-surendran-2016\/\"> <span class=\"screen-reader-text\">Presi\u00f3n arterial (Surendran, 2016)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5544,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10605","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"<!-- 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