{"id":10686,"date":"2021-01-06T00:33:25","date_gmt":"2021-01-06T05:33:25","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-colitis-ulcerosa-anderson-2011\/"},"modified":"2021-02-20T20:32:12","modified_gmt":"2021-02-21T01:32:12","slug":"genetica-de-colitis-ulcerosa-anderson-2011","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-de-colitis-ulcerosa-anderson-2011\/","title":{"rendered":"Colitis ulcerosa (Anderson, 2011)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> El metan\u00e1lisis identifica 29 loci de riesgo de colitis ulcerosa adicionales, lo que aumenta el n\u00famero de asociaciones confirmadas a 47<\/a><\/p>\n\n

RESUMEN:<\/strong> Las variantes gen\u00e9ticas relacionadas con la inflamaci\u00f3n y la muerte celular programada pueden afectar el riesgo de colitis ulcerosa.<\/p>\n\n

DESCRIPCI\u00d3N:<\/strong> La colitis ulcerosa (CU) es una enfermedad inflamatoria intestinal que ocurre cuando se desarrollan llagas en el colon debido a una inflamaci\u00f3n continua. Los s\u00edntomas como diarrea, dolor abdominal y fatiga generalmente se desarrollan con el tiempo. Tambi\u00e9n se sabe que la CU es hereditaria, pero los factores gen\u00e9ticos subyacentes a esto no se comprenden bien. Este estudio examin\u00f3 a m\u00e1s de 40.000 individuos de ascendencia europea y descubri\u00f3 29 variantes gen\u00e9ticas novedosas asociadas con la CU. Muchas de estas variantes estaban previamente relacionadas con la muerte celular programada y el sistema inmunol\u00f3gico, en particular la inflamaci\u00f3n. Se estima que las nuevas variantes explican el 16% de la heredabilidad de la CU, y todas las variantes significativas explican el 28% de su heredabilidad.<\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Para reducir los s\u00edntomas de la colitis ulcerosa, beba mucha agua, limite los productos l\u00e1cteos y haga ejercicio con regularidad. [ FUENTE<\/a> ]<\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> .<\/p>\n\n

\"Informe<\/a><\/figure>\n\n

VARIANTES ASOCIADAS A UC:<\/strong> rs9268853, rs6426833, rs11209026, rs10758669, rs2836878, rs6871626, rs6584283, rs6017342, rs1801274, rs10781499, rs16940202, rs9822268, rs3024505, rs6920220, rs17085007, rs7134599, rs4510766, rs2155219, rs798502, rs7608910, rs678170, rs7524102, rs7554511, rs1297265, rs2310173, rs941823, rs4246905, rs267939, rs2872507, rs2838519, rs4676406, rs11676348, rs907611, rs2297441, rs943072, rs12261843, rs254560, rs6451493 *, rs73534560, rs6451493 *, rs73534560, rs6451493 *, rs73534560, rs6451493 *, rs735675490<\/p>\n\n

RECURSOS ADICIONALES:<\/strong> Colitis ulcerosa: s\u00edntomas y causas<\/a>Muerte celular programada (video)<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 30 de agosto de 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: El metan\u00e1lisis identifica 29 loci de riesgo de colitis ulcerosa adicionales, lo que aumenta el n\u00famero de asociaciones confirmadas a 47 RESUMEN: Las variantes gen\u00e9ticas relacionadas con la inflamaci\u00f3n y la muerte celular programada pueden afectar el …<\/p>\n

Colitis ulcerosa (Anderson, 2011)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5699,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10686","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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