{"id":10869,"date":"2021-01-06T00:36:51","date_gmt":"2021-01-06T05:36:51","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-nefropatia-membranosa-xie-2020\/"},"modified":"2021-02-20T20:24:08","modified_gmt":"2021-02-21T01:24:08","slug":"genetica-de-nefropatia-membranosa-xie-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-de-nefropatia-membranosa-xie-2020\/","title":{"rendered":"Nefropat\u00eda membranosa (Xie, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> La arquitectura gen\u00e9tica de la nefropat\u00eda membranosa y su potencial para mejorar el diagn\u00f3stico no invasivo<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de 4 regiones gen\u00f3micas asociadas con nefropat\u00eda membranosa, una autoinmune<\/em> enfermedad de los ri\u00f1ones. <\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> Los ri\u00f1ones son \u00f3rganos que eliminan los desechos y el exceso de agua de la sangre, que eventualmente termina como orina. La nefropat\u00eda membranosa (MN) es una autoinmune<\/em> enfermedad que conduce a insuficiencia renal. Este estudio de asociaci\u00f3n de todo el genoma intent\u00f3 identificar variantes gen\u00e9ticas asociadas con un mayor riesgo de nefropat\u00eda membranosa. Al examinar los datos gen\u00e9ticos de m\u00e1s de 12.000 individuos de ascendencia europea y del este de Asia, 4 regiones del genoma se correlacionaron con un mayor riesgo de NM. Todas las variantes identificadas est\u00e1n cerca de genes relacionados con la funci\u00f3n del sistema inmunol\u00f3gico, lo que subraya que la nefropat\u00eda membranosa es una autoinmune<\/em> enfermedad. Adem\u00e1s, las variantes se han relacionado previamente con la enfermedad inflamatoria intestinal, otro autoinmune<\/em> condici\u00f3n. <\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Los tratamientos para la nefropat\u00eda membranosa incluyen medicamentos que hacen que los pacientes orinen m\u00e1s y una dieta baja en sal. Tambi\u00e9n se utilizan medicamentos que ayudan a mantener el sistema inmunol\u00f3gico bajo control. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS A MN:<\/strong> rs9271573, rs17831251, rs9405192, rs230540 <\/p>\n\n

RECURSOS ADICIONALES:<\/strong>Tus ri\u00f1ones y c\u00f3mo funcionan<\/a> Neuropat\u00eda membranosa (video)<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 21 de abril de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: La arquitectura gen\u00e9tica de la nefropat\u00eda membranosa y su potencial para mejorar el diagn\u00f3stico no invasivo RESUMEN: Identificaci\u00f3n de 4 regiones gen\u00f3micas asociadas con nefropat\u00eda membranosa, una autoinmune enfermedad de los ri\u00f1ones. VISI\u00d3N GENERAL: Los ri\u00f1ones son …<\/p>\n

Nefropat\u00eda membranosa (Xie, 2020)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6234,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-10869","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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