{"id":9629,"date":"2021-01-05T23:24:01","date_gmt":"2021-01-06T04:24:01","guid":{"rendered":"https:\/\/nebula.org\/blog\/susceptibilidad-sars-cov-2\/"},"modified":"2021-02-20T20:46:01","modified_gmt":"2021-02-21T01:46:01","slug":"susceptibilidad-sars-cov-2","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/susceptibilidad-sars-cov-2\/","title":{"rendered":"COVID-19 y el brote de SARS de 2003"},"content":{"rendered":"\n

Introducci\u00f3n al SARS<\/strong><\/h2>\n\n

El coronavirus del s\u00edndrome respiratorio agudo severo (SARS-CoV) surgi\u00f3 en 2003<\/a> en China. Sigui\u00f3 una epidemia que se extendi\u00f3 por 26 pa\u00edses e infect\u00f3 a m\u00e1s de 8000 personas antes de que el virus fuera contenido. Los s\u00edntomas t\u00edpicos del SARS son similares a los de la gripe, como fiebre, dolor de cabeza y sensaci\u00f3n general de malestar. Los casos graves de la enfermedad fueron comunes, lo que result\u00f3 en una tasa de mortalidad de casi el 10%. Debido a la gravedad de los s\u00edntomas, fue posible<\/a> para identificar a los infectados con SARS-CoV y aislarlos. Medidas de salud p\u00fablica como distanciamiento social<\/a> tuvieron \u00e9xito en contener el brote. <\/p>\n\n

SARS y la pandemia de COVID-19<\/strong><\/h2>\n\n

La situaci\u00f3n es diferente con la de hoy Pandemia de COVID-19<\/a> . Este nuevo coronavirus (SARS-CoV-2) puede infectar a personas que luego permanecen en gran parte asintom\u00e1tico<\/a> . Esto hace que sea mucho m\u00e1s dif\u00edcil identificar y contener a los infectados que contin\u00faan propagando la enfermedad. Aunque la tasa de mortalidad de COVID-19 es estimado<\/a> Al ser de 5 a 10 veces menor que el SARS, el n\u00famero total de muertes ya super\u00f3 el brote de SARS debido a que no se logr\u00f3 contener la pandemia. <\/p>\n\n

Sin embargo, el SARS-CoV y el SARS-CoV-2 tambi\u00e9n comparten muchos similitudes<\/a> . Ambos virus se originaron en murci\u00e9lagos y comparten el 80% de su c\u00f3digo gen\u00e9tico. Adem\u00e1s, ambos virus infectan el tracto respiratorio utilizando el mismo mecanismo<\/a> y provocan s\u00edntomas similares. <\/p>\n\n

Mientras nuestra comprensi\u00f3n de COVID-19<\/a> a\u00fan falta, se han realizado muchas investigaciones sobre el SARS en los a\u00f1os posteriores a 2003. Los investigadores han identificado variantes gen\u00e9ticas que est\u00e1n asociadas con la susceptibilidad a la infecci\u00f3n por el SARS-CoV. Sigue siendo una pregunta abierta si las mismas variantes gen\u00e9ticas tambi\u00e9n est\u00e1n asociadas con la susceptibilidad a la infecci\u00f3n por SARS-CoV-2 dadas las similitudes entre los dos coronavirus. <\/p>\n\n

Para informar a nuestros usuarios sobre investigaciones anteriores sobre coronavirus, agregamos 3 estudios sobre la infecci\u00f3n por coronavirus del SARS al Biblioteca de investigaci\u00f3n de nebulosa<\/a> . Estos estudios nos dan cierta comprensi\u00f3n de los v\u00ednculos entre la gen\u00e9tica humana y la infecci\u00f3n por coronavirus.<\/p>\n\n

\"Casos
El n\u00famero de casos de COVID-19 ha superado el n\u00famero de casos de SARS a principios de febrero de 2020. Fuente: statista \/ CDC<\/a> .<\/figcaption><\/figure>\n\n

<\/p>\n\n

Entradas de la Biblioteca Nebula sobre el SARS<\/strong><\/h2>\n\n

Infecci\u00f3n por coronavirus del SARS (Hamano, 2005)<\/h4>\n\n

Este estudio explor\u00f3 datos gen\u00e9ticos de individuos vietnamitas e identific\u00f3 una variante gen\u00e9tica en el OEA-1<\/em> gen que est\u00e1 asociado con la susceptibilidad a la infecci\u00f3n por el coronavirus del SARS.<\/p>\n\n

Infecci\u00f3n por coronavirus del SARS (Ching, 2010)<\/h4>\n\n

Este estudio utiliz\u00f3 datos gen\u00e9ticos de individuos chinos para demostrar que una variante gen\u00e9tica est\u00e1 relacionada con una menor susceptibilidad a la infecci\u00f3n por coronavirus del SARS. Esta variante se encuentra cerca del MxA<\/em> gen, que normalmente juega un papel en la inhibici\u00f3n de la replicaci\u00f3n de los coronavirus del SARS.<\/p>\n\n

Infecci\u00f3n por coronavirus del SARS (Tu, 2015)<\/h4>\n\n

Este estudio examin\u00f3 los datos gen\u00e9ticos de pacientes chinos con SRAS para identificar variantes en 2 genes que conducen a un mayor riesgo de infecci\u00f3n. Una variante est\u00e1 en el CCL2<\/em> gen, que juega un papel en la atracci\u00f3n de macr\u00f3fagos a un sitio de infecci\u00f3n. La otra variante est\u00e1 en el MBL<\/em> gen, que ayuda al sistema inmunol\u00f3gico a reconocer patrones moleculares que se encuentran com\u00fanmente en la superficie de muchos virus y bacterias.<\/p>\n\n

Nueva investigaci\u00f3n de COVID-19<\/strong><\/h2>\n\n

En poco tiempo, se publicar\u00e1n estudios sobre la susceptibilidad al SARS-CoV-2 y el papel de la gen\u00e9tica. Aqu\u00ed en Nebula, estamos monitoreando la investigaci\u00f3n sobre COVID-19 y brindaremos a nuestros usuarios actualizaciones oportunas. Puede mantenerse actualizado con los \u00faltimos descubrimientos de investigaci\u00f3n comprando nuestro secuenciaci\u00f3n del genoma completo<\/a> o subiendo tu existente Datos de 23andMe o AncestryDNA<\/a> .<\/p>\n\n

Para obtener actualizaciones sobre la gen\u00e9tica de COVID-19, visite: https:\/\/nebula.org\/blog\/category\/science\/<\/a><\/p>\n\n

Tambi\u00e9n puede obtener m\u00e1s informaci\u00f3n sobre las pruebas de coronavirus en esta publicaci\u00f3n de blog.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Introducci\u00f3n al SARS El coronavirus del s\u00edndrome respiratorio agudo severo (SARS-CoV) surgi\u00f3 en 2003 en China. Sigui\u00f3 una epidemia que se extendi\u00f3 por 26 pa\u00edses e infect\u00f3 a m\u00e1s de 8000 personas antes de que el virus fuera contenido. Los …<\/p>\n

COVID-19 y el brote de SARS de 2003<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":11,"featured_media":5944,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4979],"tags":[],"class_list":["post-9629","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencias"],"yoast_head":"\nSusceptibilidad 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