{"id":9872,"date":"2021-01-06T00:02:22","date_gmt":"2021-01-06T05:02:22","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-del-mosaico-perdida-del-cromosoma-y-terao-2019\/"},"modified":"2021-02-20T20:42:04","modified_gmt":"2021-02-21T01:42:04","slug":"genetica-del-mosaico-perdida-del-cromosoma-y-terao-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-del-mosaico-perdida-del-cromosoma-y-terao-2019\/","title":{"rendered":"P\u00e9rdida de mosaico del cromosoma Y (Terao, 2019)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> GWAS de la p\u00e9rdida en mosaico del cromosoma Y destaca los efectos gen\u00e9ticos en la diferenciaci\u00f3n de las c\u00e9lulas sangu\u00edneas<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de 46 variantes gen\u00e9ticas asociadas con la p\u00e9rdida en mosaico del cromosoma Y (mLOY).<\/p>\n\n

DESCRIPCI\u00d3N:<\/strong> Las c\u00e9lulas del cuerpo humano almacenan informaci\u00f3n gen\u00e9tica en 23 pares de cromosomas. mLOY es una afecci\u00f3n espec\u00edfica de los hombres caracterizada por la p\u00e9rdida del cromosoma Y por algunas c\u00e9lulas. mLOY se ha relacionado con diversas afecciones m\u00e9dicas, incluido el c\u00e1ncer, y se observa con mayor frecuencia en los gl\u00f3bulos blancos de los hombres que envejecen. Este estudio de asociaci\u00f3n de todo el genoma analiz\u00f3 los datos gen\u00e9ticos de 95.380 hombres japoneses para comprender mejor los factores gen\u00e9ticos que contribuyen a esta afecci\u00f3n. El estudio descubri\u00f3 46 variantes gen\u00e9ticas de las cuales 35 son nuevas y, en conjunto, estas variantes explican aproximadamente el 9% de la heredabilidad de mLOY. Muchas de las variantes gen\u00e9ticas identificadas est\u00e1n cerca de genes activos en las c\u00e9lulas madre sangu\u00edneas.<\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Los estudios han demostrado que fumar puede aumentar significativamente el riesgo de p\u00e9rdida en mosaico del cromosoma Y. Hay buenas noticias para los fumadores que buscan dejar de fumar: la misma investigaci\u00f3n mostr\u00f3 que los fumadores anteriores no ten\u00edan m\u00e1s probabilidades de perder el cromosoma Y que los que nunca hab\u00edan fumado. [ FUENTE<\/a> ]<\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> .<\/p>\n\n

\"Ejemplo<\/a><\/figure>\n\n

VARIANTES ASOCIADAS A LA MLOY:<\/strong> rs56116444, rs80277818, rs2842873, rs72698721, rs59543286, rs4709819, rs227079, rs4721217, rs2237896, rs78997619, rs55727837, rs34324, rs11769630, rs4681200, rs4683900, rs10849448, rs728739, rs871134, rs35355140, rs138423884, rs34468831, rs10948011, rs9921295, rs17049722, rs11251, rs77406149, rs2646425, rs2811487, rs1859259, rs12668837, rs34778241, rs2853677, rs9299129, rs527504, rs77874075, rs10692222, rs548509555, rs117587217, rs201753350, rs12225799, rs79058858, rs74843651, rs189309686, rs2804301, rs2979469<\/p>\n\n

RECURSOS ADICIONALES:<\/strong> Cromosomas sexuales<\/a>C\u00e9lula madre hematopoy\u00e9tica<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 24 de octubre de 2019<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: GWAS de la p\u00e9rdida en mosaico del cromosoma Y destaca los efectos gen\u00e9ticos en la diferenciaci\u00f3n de las c\u00e9lulas sangu\u00edneas RESUMEN: Identificaci\u00f3n de 46 variantes gen\u00e9ticas asociadas con la p\u00e9rdida en mosaico del cromosoma Y (mLOY). DESCRIPCI\u00d3N: …<\/p>\n

P\u00e9rdida de mosaico del cromosoma Y (Terao, 2019)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5754,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-9872","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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