{"id":9998,"date":"2021-01-06T00:04:07","date_gmt":"2021-01-06T05:04:07","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-la-edad-relacionada-degeneracion-macular-han-2020\/"},"modified":"2021-02-20T20:23:34","modified_gmt":"2021-02-21T01:23:34","slug":"genetica-de-la-edad-relacionada-degeneracion-macular-han-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/es\/genetica-de-la-edad-relacionada-degeneracion-macular-han-2020\/","title":{"rendered":"Degeneraci\u00f3n macular relacionada con la edad (Han, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DEL ESTUDIO:<\/strong> El metaan\u00e1lisis de todo el genoma identifica nuevos loci asociados con la degeneraci\u00f3n macular relacionada con la edad<\/a><\/p>\n\n

RESUMEN:<\/strong> Identificaci\u00f3n de 12 nuevas regiones gen\u00f3micas asociadas con la degeneraci\u00f3n macular relacionada con la edad.<\/p>\n\n

VISI\u00d3N GENERAL:<\/strong> La retina es la capa nerviosa sensible a la luz que recubre la parte posterior del ojo. La degeneraci\u00f3n macular relacionada con la edad (DMAE) describe el da\u00f1o a la m\u00e1cula, el \u00e1rea de la retina que es responsable de la visi\u00f3n de color central de alta resoluci\u00f3n. La ARMD, la principal causa de ceguera entre las personas mayores, afecta a casi 160 millones de personas en todo el mundo. Este estudio de asociaci\u00f3n de todo el genoma tuvo como objetivo identificar variantes gen\u00e9ticas asociadas con ARMD mediante el examen de los genomas de ~ 132.000 individuos de ascendencia mayoritariamente europea. Los investigadores identificaron 69 variantes gen\u00e9ticas asociadas con ARMD, 12 de las cuales son nuevas. Algunos de los genes implicados funcionan en v\u00edas de respuesta inflamatoria y rasgos oculares, como el grosor macular. <\/p>\n\n

\u00bfSAB\u00cdAS?<\/strong> Hay dos tipos de degeneraci\u00f3n macular: seca y h\u00fameda. El tipo h\u00famedo se caracteriza por el crecimiento anormal de vasos sangu\u00edneos en la m\u00e1cula. La degeneraci\u00f3n macular h\u00fameda a menudo se trata con medicamentos que ralentizan el crecimiento de los vasos sangu\u00edneos. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE LA MUESTRA:<\/strong> M\u00e1s informaci\u00f3n sobre el Biblioteca de investigaci\u00f3n de nebulosa<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASOCIADAS A ARMD:<\/strong> rs800292, rs7542235, rs2248799, rs6428365, rs2672589, rs7555070, rs12116643, rs760070, rs2672590, rs12134610, rs11200607, rs163494, rs7918867, rs4752699, rs4151671, rs10494757, rs4420638, rs1337169, rs12211410, rs5754227, rs1329423, rs247616, rs5754206, rs11076175, rs1998345, rs943080, rs10033900, rs11569520, rs2043085, rs7266392, rs7428936, rs8135665, rs2070895, rs8017304, rs13255394, rs401186, rs11771241, rs13081855, rs12949956, rs2575876, rs9973159, rs4943289, rs1142, rs2268354, rs10781180, rs1605677, rs8056814, rs3138142, rs6899205, rs11080055, rs1064583, rs3760775, rs3825991, rs1926564, rs11142636, rs11884770, rs1378940, rs2842343, rs259842, rs11120691, rs2367070, rs2011092, rs7896471, rs1642661913, rs1742661913, rs1742661913<\/p>\n\n

RECURSOS ADICIONALES:<\/strong>Degeneraci\u00f3n macular relacionada con la edad (video)<\/a>Ceguera y discapacidad visual<\/a><\/p>\n\n

ACTUALIZACI\u00d3N SEMANAL:<\/strong> 21 de abril de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DEL ESTUDIO: El metaan\u00e1lisis de todo el genoma identifica nuevos loci asociados con la degeneraci\u00f3n macular relacionada con la edad RESUMEN: Identificaci\u00f3n de 12 nuevas regiones gen\u00f3micas asociadas con la degeneraci\u00f3n macular relacionada con la edad. VISI\u00d3N GENERAL: La …<\/p>\n

Degeneraci\u00f3n macular relacionada con la edad (Han, 2020)<\/span> Leer m\u00e1s \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6244,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4982],"tags":[],"class_list":["post-9998","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-informes"],"yoast_head":"\nLa 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