{"id":10006,"date":"2021-01-06T00:04:13","date_gmt":"2021-01-06T05:04:13","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetics-of-qt-interval-arking-2014\/"},"modified":"2021-02-20T20:22:04","modified_gmt":"2021-02-21T01:22:04","slug":"genetics-of-qt-interval-arking-2014","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetics-of-qt-interval-arking-2014\/","title":{"rendered":"Intervalle QT (Arking, 2014)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> L’\u00e9tude d’association g\u00e9n\u00e9tique de l’intervalle QT met en \u00e9vidence le r\u00f4le des voies de signalisation du calcium dans la repolarisation myocardique<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 22 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la dur\u00e9e de l’intervalle QT, qui est le temps n\u00e9cessaire \u00e0 un c\u0153ur pour se recharger pour le battement. <\/p>\n\n

APER\u00c7U:<\/strong> Une onde \u00e9lectrique traverse votre c\u0153ur \u00e0 chaque fois qu’elle bat. Apr\u00e8s chaque battement de c\u0153ur, votre c\u0153ur met du temps \u00e0 se repolariser ou \u00e0 se \u00abrecharger\u00bb avant le prochain battement de c\u0153ur. Cette heure est connue sous le nom d’intervalle QT. Plus l’intervalle QT est long, plus il faut de temps \u00e0 votre c\u0153ur pour se recharger entre les battements cardiaques. Des intervalles trop longs sont un facteur de risque de maladies cardiaques, telles que des battements cardiaques anormaux et une mort cardiaque subite. Cette \u00e9tude a examin\u00e9 les g\u00e9nomes de plus de 100 000 individus, dont la plupart \u00e9taient d’origine europ\u00e9enne, afin de mieux comprendre la base g\u00e9n\u00e9tique de la dur\u00e9e de l’intervalle QT. L’\u00e9tude a identifi\u00e9 35 r\u00e9gions g\u00e9nomiques associ\u00e9es au trait, dont 22 sont nouvelles. Plusieurs de ces r\u00e9gions g\u00e9nomiques codent pour des prot\u00e9ines impliqu\u00e9es dans la voie de signalisation du calcium, soulignant l’importance de la signalisation du calcium dans la recharge du c\u0153ur. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> La dur\u00e9e de l’intervalle QT peut \u00eatre mesur\u00e9e avec un \u00e9lectrocardiogramme (ECG). C’est un test courant et indolore qui ne prend que cinq \u00e0 dix minutes environ. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"Résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 QT:<\/strong> rs12143842, rs11153730, rs246196, rs7122937, rs2072413, rs846111, rs10919070, rs735951, rs6793245, rs1396515, rs1052536, rs1805128, rs2298632, rs9892651, rs12997023, rs246185, rs3026445, rs3105593, rs295140, rs2273905, rs10040989, rs174583, rs11779860, rs7765828, rs1296720, rs938291, rs2363719, rs3857067, rs16936870, rs1961102, rs7561149, rs728926, rs17784882, rs9920, rs2485376<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Intervalle QT (vid\u00e9o)<\/a> Intervalle QT long<\/a>Troubles de la conduction cardiaque<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 28 avril 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: L’\u00e9tude d’association g\u00e9n\u00e9tique de l’intervalle QT met en \u00e9vidence le r\u00f4le des voies de signalisation du calcium dans la repolarisation myocardique SOMMAIRE: Identification de 22 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la dur\u00e9e de l’intervalle QT, qui est …<\/p>\n

Intervalle QT (Arking, 2014)<\/span> Lire la suite 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