{"id":10007,"date":"2021-01-06T00:04:13","date_gmt":"2021-01-06T05:04:13","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-dermatite-atopique-paternoster-2015\/"},"modified":"2021-02-20T20:28:41","modified_gmt":"2021-02-21T01:28:41","slug":"genetique-de-dermatite-atopique-paternoster-2015","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-dermatite-atopique-paternoster-2015\/","title":{"rendered":"Dermatite atopique (Paternoster, 2015)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association multi-anc\u00eatre \u00e0 l’\u00e9chelle du g\u00e9nome de 21000 cas et 95000 t\u00e9moins identifie de nouveaux loci de risque de dermatite atopique<\/a><\/p>\n\n

SOMMAIRE:<\/strong> D\u00e9couverte de 10 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la dermatite atopique, \u00e9galement appel\u00e9e ecz\u00e9ma.<\/p>\n\n

APER\u00c7U:<\/strong> La peau est le plus grand organe du corps, servant de barri\u00e8re au monde ext\u00e9rieur. Le syst\u00e8me immunitaire contribue \u00e0 soutenir cette fonction de barri\u00e8re en s’attaquant aux substances \u00ab\u00e9trang\u00e8res\u00bb qui entrent en contact avec la peau. Lorsque cela se produit, la peau peut devenir enflamm\u00e9e, rouge et irrit\u00e9e. La dermatite atopique (DA), \u00e9galement connue sous le nom d’ecz\u00e9ma, une inflammation cutan\u00e9e est d\u00e9clench\u00e9e par des facteurs environnementaux qui ne sont en fait pas nocifs pour le corps. Parmi beaucoup d’autres, ces facteurs peuvent inclure la temp\u00e9rature, le savon et les v\u00eatements. La MA est hautement h\u00e9r\u00e9ditaire, la g\u00e9n\u00e9tique d\u00e9terminant jusqu’\u00e0 90% de la sensibilit\u00e9 d’un individu \u00e0 la maladie. Pour identifier les variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la dermatite atopique, cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome a examin\u00e9 plus de 116 000 individus d’ascendance europ\u00e9enne, africaine, japonaise et latino-am\u00e9ricaine. L’\u00e9tude a trouv\u00e9 21 r\u00e9gions du g\u00e9nome associ\u00e9es \u00e0 la dermatite atopique, dont 10 sont nouvelles. Au total, ces variantes peuvent expliquer environ 15% de la variance de la sensibilit\u00e9 \u00e0 la MA. Les r\u00e9gions g\u00e9nomiques nouvellement identifi\u00e9es comprennent des g\u00e8nes impliqu\u00e9s dans le syst\u00e8me immunitaire, en particulier la fonction des cellules T qui jouent un r\u00f4le important dans de nombreuses maladies auto-immunes. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> La dermatite atopique peut \u00eatre une affection persistante, avec des pouss\u00e9es p\u00e9riodiques. Pour aider \u00e0 r\u00e9duire la gravit\u00e9 et la fr\u00e9quence des sympt\u00f4mes, de bons soins de la peau sont essentiels. Cela comprend l’application r\u00e9guli\u00e8re d’une cr\u00e8me hydratante, en utilisant un d\u00e9tergent \u00e0 lessive \u00absans parfum\u00bb et en \u00e9vitant de rayer la peau qui d\u00e9mange. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES AD-ASSOCI\u00c9ES:<\/strong> rs61813875, rs10791824, rs12188917, rs6419573, rs2212434, rs4809219, rs2918307, rs2041733, rs12730935, rs2038255, rs7127307, rs7512552, rs64732274, rs7512552, rs64732274, rs7512552, rs6452362, r426571, rs7512552, rs6452362, r426571<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Dermatite atopique (vid\u00e9o)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 28 avril 2020<\/p>\n\n

Jetez \u00e9galement un \u0153il \u00e0 notre Revue de curologie<\/a> !<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association multi-anc\u00eatre \u00e0 l’\u00e9chelle du g\u00e9nome de 21000 cas et 95000 t\u00e9moins identifie de nouveaux loci de risque de dermatite atopique SOMMAIRE: D\u00e9couverte de 10 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la dermatite atopique, \u00e9galement appel\u00e9e …<\/p>\n

Dermatite atopique (Paternoster, 2015)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6280,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10007","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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