{"id":10031,"date":"2021-01-06T00:05:54","date_gmt":"2021-01-06T05:05:54","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-sjogrens-syndrome-lessard-2013\/"},"modified":"2021-02-20T20:25:52","modified_gmt":"2021-02-21T01:25:52","slug":"genetique-de-sjogrens-syndrome-lessard-2013","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-sjogrens-syndrome-lessard-2013\/","title":{"rendered":"Syndrome de Sj\u00f6gren (Lessard, 2013)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Des variantes \u00e0 plusieurs locus impliqu\u00e9s dans les r\u00e9ponses immunitaires inn\u00e9es et adaptatives sont associ\u00e9es au syndrome de Sj\u00f6gren<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 7 r\u00e9gions g\u00e9nomiques associ\u00e9es au risque de syndrome de Sj\u00f6gren. <\/p>\n\n

APER\u00c7U:<\/strong> Le syndrome de Sj\u00f6gren est une maladie auto-immune caract\u00e9ris\u00e9e par des yeux secs et une bouche s\u00e8che. Cela se produit lorsque le syst\u00e8me immunitaire du corps attaque par erreur des glandes, comme celles qui produisent de la salive et des larmes. En cons\u00e9quence, ces glandes deviennent enflamm\u00e9es et endommag\u00e9es. Jusqu’\u00e0 3 millions de personnes aux \u00c9tats-Unis seulement peuvent \u00eatre touch\u00e9es par le syndrome de Sj\u00f6gren. Bien que la maladie puisse toucher des personnes \u00e0 tout \u00e2ge, elle est le plus souvent diagnostiqu\u00e9e chez les femmes \u00e2g\u00e9es. Pour mieux comprendre la g\u00e9n\u00e9tique qui peut pr\u00e9disposer une personne \u00e0 la maladie, cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome a examin\u00e9 pr\u00e8s de 8 400 personnes d’origine europ\u00e9enne. L’\u00e9tude a trouv\u00e9 7 r\u00e9gions du g\u00e9nome associ\u00e9es \u00e0 la susceptibilit\u00e9 au d\u00e9veloppement du syndrome de Sj\u00f6gren. Les g\u00e8nes situ\u00e9s dans ces r\u00e9gions jouent un r\u00f4le dans le fonctionnement du syst\u00e8me immunitaire, y compris la production de prot\u00e9ines d’interf\u00e9ron favorisant l’inflammation. Ensemble, les variantes identifi\u00e9es peuvent expliquer une grande partie du risque h\u00e9r\u00e9ditaire de la maladie. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> En raison de la s\u00e9cheresse de la bouche caus\u00e9e par le syndrome de Sj\u00f6gren, les personnes touch\u00e9es ont un risque accru de d\u00e9velopper des caries et de perdre des dents. Des soins dentaires r\u00e9guliers sont fortement recommand\u00e9s aux personnes atteintes de cette maladie. Boire de l’eau, du chewing-gum et d’autres m\u00e9thodes pour stimuler la production de salive peuvent \u00e9galement aider. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"Résultats<\/a><\/figure>\n\n

VARIANTES ASSOCIES AU SYNDROME DE SJ\u00d6GREN:<\/strong> rs9271588, rs3757387, rs10553577, rs485497, rs2736345, rs7119038, rs6579837<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Syndrome de Sj\u00f6gren (vid\u00e9o)<\/a> <\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 5 mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Des variantes \u00e0 plusieurs locus impliqu\u00e9s dans les r\u00e9ponses immunitaires inn\u00e9es et adaptatives sont associ\u00e9es au syndrome de Sj\u00f6gren SOMMAIRE: Identification de 7 r\u00e9gions g\u00e9nomiques associ\u00e9es au risque de syndrome de Sj\u00f6gren. APER\u00c7U: Le syndrome de Sj\u00f6gren …<\/p>\n

Syndrome de Sj\u00f6gren (Lessard, 2013)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10031","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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