{"id":10097,"date":"2021-01-06T00:07:20","date_gmt":"2021-01-06T05:07:20","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetics-of-age-related-macular-degeneration-han-2020\/"},"modified":"2021-02-20T20:18:52","modified_gmt":"2021-02-21T01:18:52","slug":"genetics-of-age-related-macular-degeneration-han-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetics-of-age-related-macular-degeneration-han-2020\/","title":{"rendered":"D\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge (Han, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une m\u00e9ta-analyse \u00e0 l’\u00e9chelle du g\u00e9nome identifie de nouveaux loci associ\u00e9s \u00e0 la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 12 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge.<\/p>\n\n

APER\u00c7U:<\/strong> La r\u00e9tine est la couche nerveuse sensible \u00e0 la lumi\u00e8re qui tapisse l’arri\u00e8re de l’\u0153il. La d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge (ARMD) d\u00e9crit des l\u00e9sions de la macula, la zone de la r\u00e9tine responsable de la vision centrale des couleurs \u00e0 haute r\u00e9solution. L’ARMD, premi\u00e8re cause de c\u00e9cit\u00e9 chez les personnes \u00e2g\u00e9es, touche pr\u00e8s de 160 millions de personnes dans le monde. Cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome visait \u00e0 identifier les variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 l’ARMD en examinant les g\u00e9nomes d’environ 132 000 individus d’origine principalement europ\u00e9enne. Les chercheurs ont identifi\u00e9 69 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 l’ARMD, dont 12 sont nouvelles. Certains des g\u00e8nes impliqu\u00e9s fonctionnent dans les voies de r\u00e9ponse inflammatoire et les traits oculaires, tels que l’\u00e9paisseur maculaire. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Il existe deux types de d\u00e9g\u00e9n\u00e9rescence maculaire: s\u00e8che et humide. Le type humide est caract\u00e9ris\u00e9 par la croissance anormale des vaisseaux sanguins dans la macula. La d\u00e9g\u00e9n\u00e9rescence maculaire humide est souvent trait\u00e9e avec des m\u00e9dicaments qui ralentissent la croissance des vaisseaux sanguins. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 L’ARMD:<\/strong> rs800292, rs7542235, rs2248799, rs6428365, rs2672589, rs7555070, rs12116643, rs760070, rs2672590, rs12134610, rs11200607, rs163494, rs7918867, rs4752699, rs4151671, rs10494757, rs4420638, rs1337169, rs12211410, rs5754227, rs1329423, rs247616, rs5754206, rs11076175, rs1998345, rs943080, rs10033900, rs11569520, rs2043085, rs7266392, rs7428936, rs8135665, rs2070895, rs8017304, rs13255394, rs401186, rs11771241, rs13081855, rs12949956, rs2575876, rs9973159, rs4943289, rs1142, rs2268354, rs10781180, rs1605677, rs8056814, rs3138142, rs6899205, rs11080055, rs1064583, rs3760775, rs3825991, rs1926564, rs11142636, rs11884770, rs1378940, rs2842343, rs259842, rs11120691, rs2367070, rs2011092, rs789644271, rs1758s1758, rs1758s1758<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>D\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge (vid\u00e9o)<\/a>C\u00e9cit\u00e9 et d\u00e9ficience visuelle<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 21 avril 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une m\u00e9ta-analyse \u00e0 l’\u00e9chelle du g\u00e9nome identifie de nouveaux loci associ\u00e9s \u00e0 la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge SOMMAIRE: Identification de 12 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge. APER\u00c7U: La r\u00e9tine est …<\/p>\n

D\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l’\u00e2ge (Han, 2020)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6240,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10097","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa g\u00e9n\u00e9tique de la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l'\u00e2ge (Han, 2020)<\/title>\n<meta name=\"description\" content=\"T\u00e9l\u00e9chargez vos donn\u00e9es ADN, explorez les variantes g\u00e9n\u00e9tiques li\u00e9es \u00e0 la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l'\u00e2ge (Han, 2020) et d\u00e9couvrez votre score polyg\u00e9nique.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/fr\/genetics-of-age-related-macular-degeneration-han-2020\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La g\u00e9n\u00e9tique de la d\u00e9g\u00e9n\u00e9rescence maculaire li\u00e9e \u00e0 l'\u00e2ge (Han, 2020)\" \/>\n<meta property=\"og:description\" content=\"T\u00e9l\u00e9chargez vos donn\u00e9es ADN, explorez les 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He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/fr\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/posts\/10097","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/comments?post=10097"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/posts\/10097\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/media\/6240"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/media?parent=10097"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/categories?post=10097"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/fr\/wp-json\/wp\/v2\/tags?post=10097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}