{"id":10098,"date":"2021-01-06T00:07:21","date_gmt":"2021-01-06T05:07:21","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-calculs-biliaires-ferkingstad-2018\/"},"modified":"2021-02-20T20:20:19","modified_gmt":"2021-02-21T01:20:19","slug":"genetique-de-calculs-biliaires-ferkingstad-2018","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-calculs-biliaires-ferkingstad-2018\/","title":{"rendered":"Calculs biliaires (Ferkingstad, 2018)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> La m\u00e9ta-analyse d’association pang\u00e9nomique donne 20 loci associ\u00e9s \u00e0 la maladie des calculs biliaires<\/a><\/p>\n\n

SOMMAIRE:<\/strong> D\u00e9couverte de 21 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la formation de calculs biliaires. <\/p>\n\n

APER\u00c7U:<\/strong> La v\u00e9sicule biliaire stocke un liquide appel\u00e9 bile. Il lib\u00e8re de la bile dans les intestins o\u00f9 il facilite la digestion. La bile contient des acides biliaires qui sont produits dans le corps \u00e0 partir du cholest\u00e9rol. Les calculs biliaires sont des calculs qui peuvent se former dans la v\u00e9sicule biliaire lorsqu’il y a trop de cholest\u00e9rol et pas assez d’acides biliaires. Les calculs peuvent causer des douleurs dans l’abdomen sup\u00e9rieur droit et peuvent n\u00e9cessiter une intervention chirurgicale. Pour identifier les variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la formation de calculs biliaires, cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome a examin\u00e9 les g\u00e9nomes de plus de 750 000 individus d’origine europ\u00e9enne. L’\u00e9tude a identifi\u00e9 28 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la maladie des calculs biliaires, dont 21 sont nouvelles. Certaines de ces variantes g\u00e9n\u00e9tiques ont d\u00e9j\u00e0 \u00e9t\u00e9 li\u00e9es au diab\u00e8te et au m\u00e9tabolisme des graisses. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Selon le Guinness World Records, le plus grand nombre de calculs biliaires pr\u00e9lev\u00e9s sur un patient \u00e9tait d’environ 24000. En revanche, la plupart des patients qui subissent une intervention chirurgicale pour une maladie des calculs biliaires en ont en moyenne 2 \u00e0 20. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 LA PIERRE GALERIE:<\/strong> rs11887534, rs212100, rs12633863, rs4148808, rs2291428, rs2290846, rs1800961, rs6471717, rs601338, rs686030, rs756082276, rs28929474, rs1260326, rs34851490, rs1169288, rs756935975, rs13280055, rs56398830, rs174567, rs708686, rs11012737, rs1935, rs2469991, rs17240268, rs2070959, rs12004, rs55971546, rs11641445, rs17138478, rs45575636, rs2292553, rs12968116<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Calculs biliaires (vid\u00e9o)<\/a> Maladie biliaire<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 28 avril 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: La m\u00e9ta-analyse d’association pang\u00e9nomique donne 20 loci associ\u00e9s \u00e0 la maladie des calculs biliaires SOMMAIRE: D\u00e9couverte de 21 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la formation de calculs biliaires. APER\u00c7U: La v\u00e9sicule biliaire stocke un liquide appel\u00e9 bile. Il …<\/p>\n

Calculs biliaires (Ferkingstad, 2018)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6270,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10098","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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