{"id":10117,"date":"2021-01-06T00:07:37","date_gmt":"2021-01-06T05:07:37","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-poumon-adenocarcinome-mckay-2017\/"},"modified":"2021-02-20T20:27:22","modified_gmt":"2021-02-21T01:27:22","slug":"genetique-poumon-adenocarcinome-mckay-2017","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-poumon-adenocarcinome-mckay-2017\/","title":{"rendered":"Ad\u00e9nocarcinome pulmonaire (McKay, 2017)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une analyse d’association \u00e0 grande \u00e9chelle identifie de nouveaux loci de susceptibilit\u00e9 au cancer du poumon et une h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 de la susceptibilit\u00e9 g\u00e9n\u00e9tique \u00e0 travers les sous-types histologiques<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 6 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 l’ad\u00e9nocarcinome pulmonaire. <\/p>\n\n

APER\u00c7U:<\/strong> Le cancer du poumon est une maladie dans laquelle les cellules des poumons se divisent de mani\u00e8re incontr\u00f4lable. L’ad\u00e9nocarcinome pulmonaire est un sous-type qui repr\u00e9sente environ 40% de tous les cancers du poumon. Elle est caus\u00e9e par des mutations dans les cellules glandulaires productrices de mucus des poumons. En moyenne, l’ad\u00e9nocarcinome pulmonaire a tendance \u00e0 se d\u00e9velopper plus lentement que les autres sous-types de cancer du poumon. Pour mieux comprendre la base g\u00e9n\u00e9tique de ce cancer, cette \u00e9tude a examin\u00e9 les g\u00e9nomes d’environ 67 000 individus. Les chercheurs ont identifi\u00e9 6 nouvelles r\u00e9gions associ\u00e9es \u00e0 l’ad\u00e9nocarcinome pulmonaire. La moiti\u00e9 de ces r\u00e9gions sont situ\u00e9es \u00e0 proximit\u00e9 de g\u00e8nes li\u00e9s \u00e0 la longueur des t\u00e9lom\u00e8res, qui se raccourcit avec l’\u00e2ge. Dans l’ensemble, les variantes g\u00e9n\u00e9tiques identifi\u00e9es contribuent \u00e0 expliquer 6,7% de l’h\u00e9ritabilit\u00e9 de ce cancer. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> L’ad\u00e9nocarcinome est le type de cancer du poumon le plus courant chez la femme. De plus, l’ad\u00e9nocarcinome est le moins associ\u00e9 au tabagisme. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 L’AD\u00c9NOCARCINOME PULMONAIRE:<\/strong> rs7705526, rs77468143, rs13080835, rs115917190, rs4236709, rs1056562, rs885518, rs41309931<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Cancer du poumon (vid\u00e9o)<\/a>Types de cancer du poumon<\/a>Vivre avec un cancer du poumon<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 12 mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une analyse d’association \u00e0 grande \u00e9chelle identifie de nouveaux loci de susceptibilit\u00e9 au cancer du poumon et une h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 de la susceptibilit\u00e9 g\u00e9n\u00e9tique \u00e0 travers les sous-types histologiques SOMMAIRE: Identification de 6 nouvelles r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 …<\/p>\n

Ad\u00e9nocarcinome pulmonaire (McKay, 2017)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6340,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10117","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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